The impact of divergence time on the nature of population structure: an example from Iceland.
The Icelandic population has been sampled in many disease association studies, providing a strong motivation to understand the structure of this population and its ramifications for disease gene mapping. Previous work using 40 microsatellites showed that the Icelandic population is relatively homoge...
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ftdoajarticles:oai:doaj.org/article:2fe91fc1238f4c86bc5cf281fc7f726a 2023-05-15T16:46:31+02:00 The impact of divergence time on the nature of population structure: an example from Iceland. Alkes L Price Agnar Helgason Snaebjorn Palsson Hreinn Stefansson David St Clair Ole A Andreassen David Reich Augustine Kong Kari Stefansson 2009-06-01T00:00:00Z https://doi.org/10.1371/journal.pgen.1000505 https://doaj.org/article/2fe91fc1238f4c86bc5cf281fc7f726a EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC2684636?pdf=render https://doaj.org/toc/1553-7390 https://doaj.org/toc/1553-7404 1553-7390 1553-7404 doi:10.1371/journal.pgen.1000505 https://doaj.org/article/2fe91fc1238f4c86bc5cf281fc7f726a PLoS Genetics, Vol 5, Iss 6, p e1000505 (2009) Genetics QH426-470 article 2009 ftdoajarticles https://doi.org/10.1371/journal.pgen.1000505 2022-12-31T06:31:13Z The Icelandic population has been sampled in many disease association studies, providing a strong motivation to understand the structure of this population and its ramifications for disease gene mapping. Previous work using 40 microsatellites showed that the Icelandic population is relatively homogeneous, but exhibits subtle population structure that can bias disease association statistics. Here, we show that regional geographic ancestries of individuals from Iceland can be distinguished using 292,289 autosomal single-nucleotide polymorphisms (SNPs). We further show that subpopulation differences are due to genetic drift since the settlement of Iceland 1100 years ago, and not to varying contributions from different ancestral populations. A consequence of the recent origin of Icelandic population structure is that allele frequency differences follow a null distribution devoid of outliers, so that the risk of false positive associations due to stratification is minimal. Our results highlight an important distinction between population differences attributable to recent drift and those arising from more ancient divergence, which has implications both for association studies and for efforts to detect natural selection using population differentiation. Article in Journal/Newspaper Iceland Directory of Open Access Journals: DOAJ Articles PLoS Genetics 5 6 e1000505 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Genetics QH426-470 |
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Genetics QH426-470 Alkes L Price Agnar Helgason Snaebjorn Palsson Hreinn Stefansson David St Clair Ole A Andreassen David Reich Augustine Kong Kari Stefansson The impact of divergence time on the nature of population structure: an example from Iceland. |
topic_facet |
Genetics QH426-470 |
description |
The Icelandic population has been sampled in many disease association studies, providing a strong motivation to understand the structure of this population and its ramifications for disease gene mapping. Previous work using 40 microsatellites showed that the Icelandic population is relatively homogeneous, but exhibits subtle population structure that can bias disease association statistics. Here, we show that regional geographic ancestries of individuals from Iceland can be distinguished using 292,289 autosomal single-nucleotide polymorphisms (SNPs). We further show that subpopulation differences are due to genetic drift since the settlement of Iceland 1100 years ago, and not to varying contributions from different ancestral populations. A consequence of the recent origin of Icelandic population structure is that allele frequency differences follow a null distribution devoid of outliers, so that the risk of false positive associations due to stratification is minimal. Our results highlight an important distinction between population differences attributable to recent drift and those arising from more ancient divergence, which has implications both for association studies and for efforts to detect natural selection using population differentiation. |
format |
Article in Journal/Newspaper |
author |
Alkes L Price Agnar Helgason Snaebjorn Palsson Hreinn Stefansson David St Clair Ole A Andreassen David Reich Augustine Kong Kari Stefansson |
author_facet |
Alkes L Price Agnar Helgason Snaebjorn Palsson Hreinn Stefansson David St Clair Ole A Andreassen David Reich Augustine Kong Kari Stefansson |
author_sort |
Alkes L Price |
title |
The impact of divergence time on the nature of population structure: an example from Iceland. |
title_short |
The impact of divergence time on the nature of population structure: an example from Iceland. |
title_full |
The impact of divergence time on the nature of population structure: an example from Iceland. |
title_fullStr |
The impact of divergence time on the nature of population structure: an example from Iceland. |
title_full_unstemmed |
The impact of divergence time on the nature of population structure: an example from Iceland. |
title_sort |
impact of divergence time on the nature of population structure: an example from iceland. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2009 |
url |
https://doi.org/10.1371/journal.pgen.1000505 https://doaj.org/article/2fe91fc1238f4c86bc5cf281fc7f726a |
genre |
Iceland |
genre_facet |
Iceland |
op_source |
PLoS Genetics, Vol 5, Iss 6, p e1000505 (2009) |
op_relation |
http://europepmc.org/articles/PMC2684636?pdf=render https://doaj.org/toc/1553-7390 https://doaj.org/toc/1553-7404 1553-7390 1553-7404 doi:10.1371/journal.pgen.1000505 https://doaj.org/article/2fe91fc1238f4c86bc5cf281fc7f726a |
op_doi |
https://doi.org/10.1371/journal.pgen.1000505 |
container_title |
PLoS Genetics |
container_volume |
5 |
container_issue |
6 |
container_start_page |
e1000505 |
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1766036619038556160 |