Comparison of clinical characteristics of Zika and dengue symptomatic infections and other acute illnesses of unidentified origin in Mexico.
Background Our purpose was to provide a detailed clinical description, of symptoms and laboratory abnormalities, and temporality in patients with confirmed Zika and dengue infections, and other acute illnesses of unidentified origin (AIUO). Methods/ principal findings This was a two-year, multicente...
Published in: | PLOS Neglected Tropical Diseases |
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Online Access: | https://doi.org/10.1371/journal.pntd.0009133 https://doaj.org/article/2f15c9dcd5fb4ecc968b38fea6b1ced9 |
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ftdoajarticles:oai:doaj.org/article:2f15c9dcd5fb4ecc968b38fea6b1ced9 2023-05-15T15:13:45+02:00 Comparison of clinical characteristics of Zika and dengue symptomatic infections and other acute illnesses of unidentified origin in Mexico. Pablo F Belaunzarán-Zamudio Allyson Mateja Paola Del Carmen Guerra-de-Blas Héctor A Rincón-León Karla Navarro-Fuentes Emilia Ruiz-Hernández Sandra Caballero-Sosa Francisco Camas-Durán Zoila Priego-Smith José G Nájera-Cancino Alexander López-Roblero Karina Del Carmen Trujillo-Murillo John H Powers Sally Hunsberger Sophia Siddiqui John H Beigel Raydel Valdés-Salgado Guillermo Ruiz-Palacios Mexican Emerging Infectious Diseases Clinical Research Network (LaRed) 2021-02-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0009133 https://doaj.org/article/2f15c9dcd5fb4ecc968b38fea6b1ced9 EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0009133 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0009133 https://doaj.org/article/2f15c9dcd5fb4ecc968b38fea6b1ced9 PLoS Neglected Tropical Diseases, Vol 15, Iss 2, p e0009133 (2021) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2021 ftdoajarticles https://doi.org/10.1371/journal.pntd.0009133 2022-12-31T13:53:10Z Background Our purpose was to provide a detailed clinical description, of symptoms and laboratory abnormalities, and temporality in patients with confirmed Zika and dengue infections, and other acute illnesses of unidentified origin (AIUO). Methods/ principal findings This was a two-year, multicenter, observational, prospective, cohort study. We collected data from patients meeting the Pan American Health Organization's modified case-definition criteria for probable Zika infection. We identified Zika, dengue chikungunya by RT-PCR in serum and urine. We compared characteristics between patients with confirmed Zika and dengue infections, Zika and AIUO, and Dengue and AIUO at baseline, Days 3,7,28 and 180 of follow-up. Most episodes (67%) consistent with the PAHO definition of probable Zika could not be confirmed as due to any flavivirus and classified as Acute Illnesses of Unidentified Origin (AIUO). Infections by Zika and dengue accounted for 8.4% and 16% of episodes. Dengue patients presented with fever, generalized non-macular rash, arthralgia, and petechiae more frequently than patients with Zika during the first 10 days of symptoms. Dengue patients presented with more laboratory abnormalities (lower neutrophils, lymphocytosis, thrombocytopenia and abnormal liver function tests), with thrombocytopenia lasting for 28 days. Zika patients had conjunctivitis, photophobia and localized macular rash more frequently than others. Few differences persisted longer than 10 days after symptoms initiation: conjunctivitis in Zika infections, and self-reported rash and petechia in dengue infections. Conclusions Our study helps characterize the variety and duration of clinical features in patients with Zika, dengue and AIUO. The lack of diagnosis in most patients points to need for better diagnostics to assist clinicians in making specific etiologic diagnoses. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 15 2 e0009133 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Pablo F Belaunzarán-Zamudio Allyson Mateja Paola Del Carmen Guerra-de-Blas Héctor A Rincón-León Karla Navarro-Fuentes Emilia Ruiz-Hernández Sandra Caballero-Sosa Francisco Camas-Durán Zoila Priego-Smith José G Nájera-Cancino Alexander López-Roblero Karina Del Carmen Trujillo-Murillo John H Powers Sally Hunsberger Sophia Siddiqui John H Beigel Raydel Valdés-Salgado Guillermo Ruiz-Palacios Mexican Emerging Infectious Diseases Clinical Research Network (LaRed) Comparison of clinical characteristics of Zika and dengue symptomatic infections and other acute illnesses of unidentified origin in Mexico. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Background Our purpose was to provide a detailed clinical description, of symptoms and laboratory abnormalities, and temporality in patients with confirmed Zika and dengue infections, and other acute illnesses of unidentified origin (AIUO). Methods/ principal findings This was a two-year, multicenter, observational, prospective, cohort study. We collected data from patients meeting the Pan American Health Organization's modified case-definition criteria for probable Zika infection. We identified Zika, dengue chikungunya by RT-PCR in serum and urine. We compared characteristics between patients with confirmed Zika and dengue infections, Zika and AIUO, and Dengue and AIUO at baseline, Days 3,7,28 and 180 of follow-up. Most episodes (67%) consistent with the PAHO definition of probable Zika could not be confirmed as due to any flavivirus and classified as Acute Illnesses of Unidentified Origin (AIUO). Infections by Zika and dengue accounted for 8.4% and 16% of episodes. Dengue patients presented with fever, generalized non-macular rash, arthralgia, and petechiae more frequently than patients with Zika during the first 10 days of symptoms. Dengue patients presented with more laboratory abnormalities (lower neutrophils, lymphocytosis, thrombocytopenia and abnormal liver function tests), with thrombocytopenia lasting for 28 days. Zika patients had conjunctivitis, photophobia and localized macular rash more frequently than others. Few differences persisted longer than 10 days after symptoms initiation: conjunctivitis in Zika infections, and self-reported rash and petechia in dengue infections. Conclusions Our study helps characterize the variety and duration of clinical features in patients with Zika, dengue and AIUO. The lack of diagnosis in most patients points to need for better diagnostics to assist clinicians in making specific etiologic diagnoses. |
format |
Article in Journal/Newspaper |
author |
Pablo F Belaunzarán-Zamudio Allyson Mateja Paola Del Carmen Guerra-de-Blas Héctor A Rincón-León Karla Navarro-Fuentes Emilia Ruiz-Hernández Sandra Caballero-Sosa Francisco Camas-Durán Zoila Priego-Smith José G Nájera-Cancino Alexander López-Roblero Karina Del Carmen Trujillo-Murillo John H Powers Sally Hunsberger Sophia Siddiqui John H Beigel Raydel Valdés-Salgado Guillermo Ruiz-Palacios Mexican Emerging Infectious Diseases Clinical Research Network (LaRed) |
author_facet |
Pablo F Belaunzarán-Zamudio Allyson Mateja Paola Del Carmen Guerra-de-Blas Héctor A Rincón-León Karla Navarro-Fuentes Emilia Ruiz-Hernández Sandra Caballero-Sosa Francisco Camas-Durán Zoila Priego-Smith José G Nájera-Cancino Alexander López-Roblero Karina Del Carmen Trujillo-Murillo John H Powers Sally Hunsberger Sophia Siddiqui John H Beigel Raydel Valdés-Salgado Guillermo Ruiz-Palacios Mexican Emerging Infectious Diseases Clinical Research Network (LaRed) |
author_sort |
Pablo F Belaunzarán-Zamudio |
title |
Comparison of clinical characteristics of Zika and dengue symptomatic infections and other acute illnesses of unidentified origin in Mexico. |
title_short |
Comparison of clinical characteristics of Zika and dengue symptomatic infections and other acute illnesses of unidentified origin in Mexico. |
title_full |
Comparison of clinical characteristics of Zika and dengue symptomatic infections and other acute illnesses of unidentified origin in Mexico. |
title_fullStr |
Comparison of clinical characteristics of Zika and dengue symptomatic infections and other acute illnesses of unidentified origin in Mexico. |
title_full_unstemmed |
Comparison of clinical characteristics of Zika and dengue symptomatic infections and other acute illnesses of unidentified origin in Mexico. |
title_sort |
comparison of clinical characteristics of zika and dengue symptomatic infections and other acute illnesses of unidentified origin in mexico. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2021 |
url |
https://doi.org/10.1371/journal.pntd.0009133 https://doaj.org/article/2f15c9dcd5fb4ecc968b38fea6b1ced9 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 15, Iss 2, p e0009133 (2021) |
op_relation |
https://doi.org/10.1371/journal.pntd.0009133 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0009133 https://doaj.org/article/2f15c9dcd5fb4ecc968b38fea6b1ced9 |
op_doi |
https://doi.org/10.1371/journal.pntd.0009133 |
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PLOS Neglected Tropical Diseases |
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15 |
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2 |
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e0009133 |
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