Creutzfeldt-Jacob Illness and Other Prion Diseases (Review)
Creutzfeldt-Jakob disease (ECJ) is a sub-acute human encephalopathy and progressive associated with a degeneration central nervous system spongiform (SNC). The ECJ belongs to the encephalopathies group transmissible spongiform with an aberrant protein metabolism prions (PrP). Its pathophysiological...
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Universidad del Zulia,Facultad de Medicina,Departamento de Enfermedades Infecciosas y Tropicales
2003
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ftdoajarticles:oai:doaj.org/article:2ed4015da7054b54b8c1777342fa56af 2023-10-01T03:54:06+02:00 Creutzfeldt-Jacob Illness and Other Prion Diseases (Review) José L Colina B Gabriela Blanchard 2003-11-01T00:00:00Z https://doaj.org/article/2ed4015da7054b54b8c1777342fa56af EN ES eng spa Universidad del Zulia,Facultad de Medicina,Departamento de Enfermedades Infecciosas y Tropicales https://produccioncientificaluz.org/index.php/kasmera/article/view/4717 https://doaj.org/toc/0075-5222 https://doaj.org/toc/2477-9628 0075-5222 2477-9628 https://doaj.org/article/2ed4015da7054b54b8c1777342fa56af Kasmera, Vol 31, Iss 2, Pp 65-70 (2003) Enfermedad de Creutzfeldt-Jakob priones encefalopatía espongiforme Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2003 ftdoajarticles 2023-09-03T00:46:31Z Creutzfeldt-Jakob disease (ECJ) is a sub-acute human encephalopathy and progressive associated with a degeneration central nervous system spongiform (SNC). The ECJ belongs to the encephalopathies group transmissible spongiform with an aberrant protein metabolism prions (PrP). Its pathophysiological mechanism exact is still not known clearly but It is thought that this neurodegeneration is related to protein accumulation altered prionics (5, 13, 14, 24, 37). The protein of prions originally identified in rodents infected with Scrapie, it is encoded for a single copy chromosomal gene, this gene is highly conserved and has been identified in more than 13 species of mammals It is usually composed by two exons not translated into 5 separate for a 2 Kb intron. The prevailing uncertainty about PrP and its conformational malleability I dictate the search for linked genes and regulatory elements that could play an active role, but to date it has not been possible to identify any gene related (molecular carbines, etc.), but if some characteristics have been observed not expected within wild genes of PrP. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic |
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English Spanish |
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Enfermedad de Creutzfeldt-Jakob priones encefalopatía espongiforme Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Enfermedad de Creutzfeldt-Jakob priones encefalopatía espongiforme Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 José L Colina B Gabriela Blanchard Creutzfeldt-Jacob Illness and Other Prion Diseases (Review) |
topic_facet |
Enfermedad de Creutzfeldt-Jakob priones encefalopatía espongiforme Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Creutzfeldt-Jakob disease (ECJ) is a sub-acute human encephalopathy and progressive associated with a degeneration central nervous system spongiform (SNC). The ECJ belongs to the encephalopathies group transmissible spongiform with an aberrant protein metabolism prions (PrP). Its pathophysiological mechanism exact is still not known clearly but It is thought that this neurodegeneration is related to protein accumulation altered prionics (5, 13, 14, 24, 37). The protein of prions originally identified in rodents infected with Scrapie, it is encoded for a single copy chromosomal gene, this gene is highly conserved and has been identified in more than 13 species of mammals It is usually composed by two exons not translated into 5 separate for a 2 Kb intron. The prevailing uncertainty about PrP and its conformational malleability I dictate the search for linked genes and regulatory elements that could play an active role, but to date it has not been possible to identify any gene related (molecular carbines, etc.), but if some characteristics have been observed not expected within wild genes of PrP. |
format |
Article in Journal/Newspaper |
author |
José L Colina B Gabriela Blanchard |
author_facet |
José L Colina B Gabriela Blanchard |
author_sort |
José L Colina B |
title |
Creutzfeldt-Jacob Illness and Other Prion Diseases (Review) |
title_short |
Creutzfeldt-Jacob Illness and Other Prion Diseases (Review) |
title_full |
Creutzfeldt-Jacob Illness and Other Prion Diseases (Review) |
title_fullStr |
Creutzfeldt-Jacob Illness and Other Prion Diseases (Review) |
title_full_unstemmed |
Creutzfeldt-Jacob Illness and Other Prion Diseases (Review) |
title_sort |
creutzfeldt-jacob illness and other prion diseases (review) |
publisher |
Universidad del Zulia,Facultad de Medicina,Departamento de Enfermedades Infecciosas y Tropicales |
publishDate |
2003 |
url |
https://doaj.org/article/2ed4015da7054b54b8c1777342fa56af |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Kasmera, Vol 31, Iss 2, Pp 65-70 (2003) |
op_relation |
https://produccioncientificaluz.org/index.php/kasmera/article/view/4717 https://doaj.org/toc/0075-5222 https://doaj.org/toc/2477-9628 0075-5222 2477-9628 https://doaj.org/article/2ed4015da7054b54b8c1777342fa56af |
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1778521418630168576 |