Urban Chikungunya in the Middle East and North Africa: A systematic review.
Background The epidemiology of Chikungunya virus (CHIKV) in the Middle East and North Africa (MENA) is not well characterized despite increasing recognition of its expanding infection and disease burden in recent years. Methodology / principal findings Following Cochrane Collaboration guidelines and...
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ftdoajarticles:oai:doaj.org/article:2e933113790b4d6aaa5ec22df4125702 2023-05-15T15:10:58+02:00 Urban Chikungunya in the Middle East and North Africa: A systematic review. John M Humphrey Natalie B Cleton Chantal B E M Reusken Marshall J Glesby Marion P G Koopmans Laith J Abu-Raddad 2017-06-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0005707 https://doaj.org/article/2e933113790b4d6aaa5ec22df4125702 EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0005707 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0005707 https://doaj.org/article/2e933113790b4d6aaa5ec22df4125702 PLoS Neglected Tropical Diseases, Vol 11, Iss 6, p e0005707 (2017) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2017 ftdoajarticles https://doi.org/10.1371/journal.pntd.0005707 2022-12-31T07:46:40Z Background The epidemiology of Chikungunya virus (CHIKV) in the Middle East and North Africa (MENA) is not well characterized despite increasing recognition of its expanding infection and disease burden in recent years. Methodology / principal findings Following Cochrane Collaboration guidelines and reporting our findings following PRISMA guidelines, we systematically reviewed records describing the human prevalence and incidence, CHIKV prevalence/infection rates in vectors, outbreaks, and reported cases for CHIKV across the MENA region. We identified 29 human seroprevalence measures, one human incidence study, one study reporting CHIKV infection rates in Aedes, and nine outbreaks and case reports/series reported in the MENA from 1970-2015. Overall, anti-CHIKV antibody or reports of autochthonous transmission were identified from 10 of 23 countries in the MENA region (Djibouti, Egypt, Iraq, Iran, Kuwait, Pakistan, Saudi Arabia, Somalia, Sudan, and Yemen), with seroprevalence measures among general populations (median 1.0%, range 0-43%) and acute febrile illness populations (median 9.8%, range 0-30%). Sudan reported the highest number of studies (n = 11) and the highest seroprevalence among general populations (median 12%, range 0-43%) and undifferentiated acute febrile illness populations (median 18%, range 10-23%). CHIKV outbreaks were reported from Djibouti, Pakistan, Sudan, and Yemen. Conclusions / significance Seroprevalence studies and outbreak reports suggest endemic transmission of urban cycle CHIKV in at least the Red Sea region and Pakistan. However, indications of seroprevalence despite a low quantity of CHIKV epidemiologic research from the region suggests that CHIKV transmission is currently underrecognized. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Prisma ENVELOPE(-58.767,-58.767,-69.200,-69.200) PLOS Neglected Tropical Diseases 11 6 e0005707 |
institution |
Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 John M Humphrey Natalie B Cleton Chantal B E M Reusken Marshall J Glesby Marion P G Koopmans Laith J Abu-Raddad Urban Chikungunya in the Middle East and North Africa: A systematic review. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Background The epidemiology of Chikungunya virus (CHIKV) in the Middle East and North Africa (MENA) is not well characterized despite increasing recognition of its expanding infection and disease burden in recent years. Methodology / principal findings Following Cochrane Collaboration guidelines and reporting our findings following PRISMA guidelines, we systematically reviewed records describing the human prevalence and incidence, CHIKV prevalence/infection rates in vectors, outbreaks, and reported cases for CHIKV across the MENA region. We identified 29 human seroprevalence measures, one human incidence study, one study reporting CHIKV infection rates in Aedes, and nine outbreaks and case reports/series reported in the MENA from 1970-2015. Overall, anti-CHIKV antibody or reports of autochthonous transmission were identified from 10 of 23 countries in the MENA region (Djibouti, Egypt, Iraq, Iran, Kuwait, Pakistan, Saudi Arabia, Somalia, Sudan, and Yemen), with seroprevalence measures among general populations (median 1.0%, range 0-43%) and acute febrile illness populations (median 9.8%, range 0-30%). Sudan reported the highest number of studies (n = 11) and the highest seroprevalence among general populations (median 12%, range 0-43%) and undifferentiated acute febrile illness populations (median 18%, range 10-23%). CHIKV outbreaks were reported from Djibouti, Pakistan, Sudan, and Yemen. Conclusions / significance Seroprevalence studies and outbreak reports suggest endemic transmission of urban cycle CHIKV in at least the Red Sea region and Pakistan. However, indications of seroprevalence despite a low quantity of CHIKV epidemiologic research from the region suggests that CHIKV transmission is currently underrecognized. |
format |
Article in Journal/Newspaper |
author |
John M Humphrey Natalie B Cleton Chantal B E M Reusken Marshall J Glesby Marion P G Koopmans Laith J Abu-Raddad |
author_facet |
John M Humphrey Natalie B Cleton Chantal B E M Reusken Marshall J Glesby Marion P G Koopmans Laith J Abu-Raddad |
author_sort |
John M Humphrey |
title |
Urban Chikungunya in the Middle East and North Africa: A systematic review. |
title_short |
Urban Chikungunya in the Middle East and North Africa: A systematic review. |
title_full |
Urban Chikungunya in the Middle East and North Africa: A systematic review. |
title_fullStr |
Urban Chikungunya in the Middle East and North Africa: A systematic review. |
title_full_unstemmed |
Urban Chikungunya in the Middle East and North Africa: A systematic review. |
title_sort |
urban chikungunya in the middle east and north africa: a systematic review. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2017 |
url |
https://doi.org/10.1371/journal.pntd.0005707 https://doaj.org/article/2e933113790b4d6aaa5ec22df4125702 |
long_lat |
ENVELOPE(-58.767,-58.767,-69.200,-69.200) |
geographic |
Arctic Prisma |
geographic_facet |
Arctic Prisma |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 11, Iss 6, p e0005707 (2017) |
op_relation |
https://doi.org/10.1371/journal.pntd.0005707 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0005707 https://doaj.org/article/2e933113790b4d6aaa5ec22df4125702 |
op_doi |
https://doi.org/10.1371/journal.pntd.0005707 |
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PLOS Neglected Tropical Diseases |
container_volume |
11 |
container_issue |
6 |
container_start_page |
e0005707 |
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1766341899245846528 |