Field evaluation of the whole blood immunochromatographic test for rapid bancroftian filariasis diagnosis in the northeast of Brazil
This study evaluated the whole blood immunochromatographic card test (ICT card test) in a survey performed in Northeastern Brazil. 625 people were examined by the thick blood film (TBF) and ICT card test. Residents of a non-endemic area were also tested by the whole blood card test and Og4C3. The se...
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Universidade de São Paulo (USP)
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ftdoajarticles:oai:doaj.org/article:2e390768ebc149199825cd863f4d92d7 2024-09-09T19:26:32+00:00 Field evaluation of the whole blood immunochromatographic test for rapid bancroftian filariasis diagnosis in the northeast of Brazil Braga Cynthia Dourado Maria Inês Ximenes Ricardo Arraes de A. Alves Luiz Brayner Fabio Rocha Abraham Alexander Neal 2003-01-01T00:00:00Z https://doaj.org/article/2e390768ebc149199825cd863f4d92d7 EN eng Universidade de São Paulo (USP) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46652003000300002 https://doaj.org/toc/0036-4665 https://doaj.org/toc/1678-9946 0036-4665 1678-9946 https://doaj.org/article/2e390768ebc149199825cd863f4d92d7 Revista do Instituto de Medicina Tropical de São Paulo, Vol 45, Iss 3, Pp 125-129 (2003) Bancroftian filariasis Diagnostic Screening Surveillance Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2003 ftdoajarticles 2024-08-05T17:49:30Z This study evaluated the whole blood immunochromatographic card test (ICT card test) in a survey performed in Northeastern Brazil. 625 people were examined by the thick blood film (TBF) and ICT card test. Residents of a non-endemic area were also tested by the whole blood card test and Og4C3. The sensitivity of the ICT card test was 94.7% overall, but lower in females than males, based on the reasonable assumption that TBF is 100% specific. However, since TBF and other methods have unknown sensitivity, the true specificity of the card test is unknown. Nevertheless, it is possible to estimate upper and lower limits for the specificity, and relate it to the prevalence of the disease. In the endemic area, the possible range of the specificity was from 72.4% to 100%. 29.6% of the card tests performed in the non-endemic area exhibited faint lines that were interpreted as positives. Characteristics of the method including high sensitivity, promptness and simplicity justify its use for screening of filariasis. However, detailed information about the correct interpretation in case of extremely faint lines is essential. Further studies designed to consider problems arising from imperfect standards are necessary, as is a sounder diagnostic definition for the card test. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic |
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Directory of Open Access Journals: DOAJ Articles |
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English |
topic |
Bancroftian filariasis Diagnostic Screening Surveillance Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
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Bancroftian filariasis Diagnostic Screening Surveillance Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Braga Cynthia Dourado Maria Inês Ximenes Ricardo Arraes de A. Alves Luiz Brayner Fabio Rocha Abraham Alexander Neal Field evaluation of the whole blood immunochromatographic test for rapid bancroftian filariasis diagnosis in the northeast of Brazil |
topic_facet |
Bancroftian filariasis Diagnostic Screening Surveillance Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
This study evaluated the whole blood immunochromatographic card test (ICT card test) in a survey performed in Northeastern Brazil. 625 people were examined by the thick blood film (TBF) and ICT card test. Residents of a non-endemic area were also tested by the whole blood card test and Og4C3. The sensitivity of the ICT card test was 94.7% overall, but lower in females than males, based on the reasonable assumption that TBF is 100% specific. However, since TBF and other methods have unknown sensitivity, the true specificity of the card test is unknown. Nevertheless, it is possible to estimate upper and lower limits for the specificity, and relate it to the prevalence of the disease. In the endemic area, the possible range of the specificity was from 72.4% to 100%. 29.6% of the card tests performed in the non-endemic area exhibited faint lines that were interpreted as positives. Characteristics of the method including high sensitivity, promptness and simplicity justify its use for screening of filariasis. However, detailed information about the correct interpretation in case of extremely faint lines is essential. Further studies designed to consider problems arising from imperfect standards are necessary, as is a sounder diagnostic definition for the card test. |
format |
Article in Journal/Newspaper |
author |
Braga Cynthia Dourado Maria Inês Ximenes Ricardo Arraes de A. Alves Luiz Brayner Fabio Rocha Abraham Alexander Neal |
author_facet |
Braga Cynthia Dourado Maria Inês Ximenes Ricardo Arraes de A. Alves Luiz Brayner Fabio Rocha Abraham Alexander Neal |
author_sort |
Braga Cynthia |
title |
Field evaluation of the whole blood immunochromatographic test for rapid bancroftian filariasis diagnosis in the northeast of Brazil |
title_short |
Field evaluation of the whole blood immunochromatographic test for rapid bancroftian filariasis diagnosis in the northeast of Brazil |
title_full |
Field evaluation of the whole blood immunochromatographic test for rapid bancroftian filariasis diagnosis in the northeast of Brazil |
title_fullStr |
Field evaluation of the whole blood immunochromatographic test for rapid bancroftian filariasis diagnosis in the northeast of Brazil |
title_full_unstemmed |
Field evaluation of the whole blood immunochromatographic test for rapid bancroftian filariasis diagnosis in the northeast of Brazil |
title_sort |
field evaluation of the whole blood immunochromatographic test for rapid bancroftian filariasis diagnosis in the northeast of brazil |
publisher |
Universidade de São Paulo (USP) |
publishDate |
2003 |
url |
https://doaj.org/article/2e390768ebc149199825cd863f4d92d7 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista do Instituto de Medicina Tropical de São Paulo, Vol 45, Iss 3, Pp 125-129 (2003) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46652003000300002 https://doaj.org/toc/0036-4665 https://doaj.org/toc/1678-9946 0036-4665 1678-9946 https://doaj.org/article/2e390768ebc149199825cd863f4d92d7 |
_version_ |
1809896130362736640 |