Characterization of a novel papillomavirus identified from a whale (Delphinapterus leucas) pharyngeal metagenomic library
Abstract Here, using viral metagenomic method, a novel whale papillomavirus (temporarily named wPV, GenBank accession number OP856597) was discovered in a whale (Delphinapterus leucas) pharyngeal metagenomic library. The complete genome size of wPV is 7179 bp, with GC content of 54.4% and a nucleoti...
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ftdoajarticles:oai:doaj.org/article:2e25b4d7f7864afeb1b9aec924961eb7 2023-05-15T16:00:29+02:00 Characterization of a novel papillomavirus identified from a whale (Delphinapterus leucas) pharyngeal metagenomic library Xiang Lu Rong Zhu Ziyuan Dai 2023-03-01T00:00:00Z https://doi.org/10.1186/s12985-023-02009-y https://doaj.org/article/2e25b4d7f7864afeb1b9aec924961eb7 EN eng BMC https://doi.org/10.1186/s12985-023-02009-y https://doaj.org/toc/1743-422X doi:10.1186/s12985-023-02009-y 1743-422X https://doaj.org/article/2e25b4d7f7864afeb1b9aec924961eb7 Virology Journal, Vol 20, Iss 1, Pp 1-8 (2023) Whale Virome Papillomavirus Gene recombination Infectious and parasitic diseases RC109-216 article 2023 ftdoajarticles https://doi.org/10.1186/s12985-023-02009-y 2023-03-26T01:33:54Z Abstract Here, using viral metagenomic method, a novel whale papillomavirus (temporarily named wPV, GenBank accession number OP856597) was discovered in a whale (Delphinapterus leucas) pharyngeal metagenomic library. The complete genome size of wPV is 7179 bp, with GC content of 54.4% and a nucleotide composition of 23.4% A, 22.3% T, 28.4% G, and 25.9% C. The viral genome has a typical papillomavirus organization pattern, and five ORFs were predicted, including two late genes encoding L1 and L2, and three early genes encoding E1, E2, and E6. Pairwise sequence comparison and phylogenetic analysis based on the L1 gene sequence indicated that wPV may be a novel species within genus Dyodeltapapillomavirus. In addition, the E2 region of wPV was predicted to have a potential recombination event. The discovery of this novel papillomavirus increases our understanding of the viral ecology of marine mammals, providing insights into possible future infectious diseases. Article in Journal/Newspaper Delphinapterus leucas Directory of Open Access Journals: DOAJ Articles Virology Journal 20 1 |
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Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Whale Virome Papillomavirus Gene recombination Infectious and parasitic diseases RC109-216 |
spellingShingle |
Whale Virome Papillomavirus Gene recombination Infectious and parasitic diseases RC109-216 Xiang Lu Rong Zhu Ziyuan Dai Characterization of a novel papillomavirus identified from a whale (Delphinapterus leucas) pharyngeal metagenomic library |
topic_facet |
Whale Virome Papillomavirus Gene recombination Infectious and parasitic diseases RC109-216 |
description |
Abstract Here, using viral metagenomic method, a novel whale papillomavirus (temporarily named wPV, GenBank accession number OP856597) was discovered in a whale (Delphinapterus leucas) pharyngeal metagenomic library. The complete genome size of wPV is 7179 bp, with GC content of 54.4% and a nucleotide composition of 23.4% A, 22.3% T, 28.4% G, and 25.9% C. The viral genome has a typical papillomavirus organization pattern, and five ORFs were predicted, including two late genes encoding L1 and L2, and three early genes encoding E1, E2, and E6. Pairwise sequence comparison and phylogenetic analysis based on the L1 gene sequence indicated that wPV may be a novel species within genus Dyodeltapapillomavirus. In addition, the E2 region of wPV was predicted to have a potential recombination event. The discovery of this novel papillomavirus increases our understanding of the viral ecology of marine mammals, providing insights into possible future infectious diseases. |
format |
Article in Journal/Newspaper |
author |
Xiang Lu Rong Zhu Ziyuan Dai |
author_facet |
Xiang Lu Rong Zhu Ziyuan Dai |
author_sort |
Xiang Lu |
title |
Characterization of a novel papillomavirus identified from a whale (Delphinapterus leucas) pharyngeal metagenomic library |
title_short |
Characterization of a novel papillomavirus identified from a whale (Delphinapterus leucas) pharyngeal metagenomic library |
title_full |
Characterization of a novel papillomavirus identified from a whale (Delphinapterus leucas) pharyngeal metagenomic library |
title_fullStr |
Characterization of a novel papillomavirus identified from a whale (Delphinapterus leucas) pharyngeal metagenomic library |
title_full_unstemmed |
Characterization of a novel papillomavirus identified from a whale (Delphinapterus leucas) pharyngeal metagenomic library |
title_sort |
characterization of a novel papillomavirus identified from a whale (delphinapterus leucas) pharyngeal metagenomic library |
publisher |
BMC |
publishDate |
2023 |
url |
https://doi.org/10.1186/s12985-023-02009-y https://doaj.org/article/2e25b4d7f7864afeb1b9aec924961eb7 |
genre |
Delphinapterus leucas |
genre_facet |
Delphinapterus leucas |
op_source |
Virology Journal, Vol 20, Iss 1, Pp 1-8 (2023) |
op_relation |
https://doi.org/10.1186/s12985-023-02009-y https://doaj.org/toc/1743-422X doi:10.1186/s12985-023-02009-y 1743-422X https://doaj.org/article/2e25b4d7f7864afeb1b9aec924961eb7 |
op_doi |
https://doi.org/10.1186/s12985-023-02009-y |
container_title |
Virology Journal |
container_volume |
20 |
container_issue |
1 |
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1766396476068462592 |