Efficacy of oxamniquine, praziquantel and a combination of both drugs in schistosomiasis mansoni in Brazil
A randomized clinical trial was carried out to compare the efficacy of a low-dosage combination of oxamniquine (7.5 mg/kg) plus praziquantel (20 mg/kg) against either agent, oxamniquine (15 mg/kg) or praziquantel (40 mg/kg) alone, in the treatment of schistosomiasis mansoni in the Brazilian north-ea...
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Universidade de São Paulo (USP)
1987
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ftdoajarticles:oai:doaj.org/article:2e10cbf77f25491593b11c457fe9e545 2024-09-09T19:25:48+00:00 Efficacy of oxamniquine, praziquantel and a combination of both drugs in schistosomiasis mansoni in Brazil K. Zwingenberger J. A. Nogueira Queiroz U. Poggensee J. E. Alencar J. Valdegunas F. Esmeralda H. Feldmeier 1987-10-01T00:00:00Z https://doi.org/10.1590/S0036-46651987000500007 https://doaj.org/article/2e10cbf77f25491593b11c457fe9e545 EN eng Universidade de São Paulo (USP) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46651987000500007&lng=en&tlng=en https://doaj.org/toc/1678-9946 1678-9946 doi:10.1590/S0036-46651987000500007 https://doaj.org/article/2e10cbf77f25491593b11c457fe9e545 Revista do Instituto de Medicina Tropical de São Paulo, Vol 29, Iss 5, Pp 305-311 (1987) Schistosoma mansoni Oxamniquine Oxamniquine resistance Praziquantel Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 1987 ftdoajarticles https://doi.org/10.1590/S0036-46651987000500007 2024-08-05T17:49:30Z A randomized clinical trial was carried out to compare the efficacy of a low-dosage combination of oxamniquine (7.5 mg/kg) plus praziquantel (20 mg/kg) against either agent, oxamniquine (15 mg/kg) or praziquantel (40 mg/kg) alone, in the treatment of schistosomiasis mansoni in the Brazilian north-east. The drugs were randomly administered per os to 91 patients. Six and twelve months after treatment 89% of those admitted to the trial were reexamined by Kato-Katz method (ten slides) and MIF technique (one gram of stool) The achieved cure rates, as defined by absence of S. mansoni eggs in the faeces of individual patients at all points during the parasitological follow-up, were 81.8%, 81.2% and 67.6% for praziquantel, oxamniquine and the combination respectively. The reduction of eggs excretion in non cured patients six months after therapy ranged from 93.8-96.8% with praziquantel, 32.5-97% with oxamniquine and 76.9-99.5% with the combination. It is concluded that, at the used dosages, the three therapeutical regimens give similar and satisfactory results in the treatment of uncomplicated S. mansoni infection in Brazil. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Revista do Instituto de Medicina Tropical de São Paulo 29 5 305 311 |
institution |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Schistosoma mansoni Oxamniquine Oxamniquine resistance Praziquantel Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
Schistosoma mansoni Oxamniquine Oxamniquine resistance Praziquantel Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 K. Zwingenberger J. A. Nogueira Queiroz U. Poggensee J. E. Alencar J. Valdegunas F. Esmeralda H. Feldmeier Efficacy of oxamniquine, praziquantel and a combination of both drugs in schistosomiasis mansoni in Brazil |
topic_facet |
Schistosoma mansoni Oxamniquine Oxamniquine resistance Praziquantel Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
A randomized clinical trial was carried out to compare the efficacy of a low-dosage combination of oxamniquine (7.5 mg/kg) plus praziquantel (20 mg/kg) against either agent, oxamniquine (15 mg/kg) or praziquantel (40 mg/kg) alone, in the treatment of schistosomiasis mansoni in the Brazilian north-east. The drugs were randomly administered per os to 91 patients. Six and twelve months after treatment 89% of those admitted to the trial were reexamined by Kato-Katz method (ten slides) and MIF technique (one gram of stool) The achieved cure rates, as defined by absence of S. mansoni eggs in the faeces of individual patients at all points during the parasitological follow-up, were 81.8%, 81.2% and 67.6% for praziquantel, oxamniquine and the combination respectively. The reduction of eggs excretion in non cured patients six months after therapy ranged from 93.8-96.8% with praziquantel, 32.5-97% with oxamniquine and 76.9-99.5% with the combination. It is concluded that, at the used dosages, the three therapeutical regimens give similar and satisfactory results in the treatment of uncomplicated S. mansoni infection in Brazil. |
format |
Article in Journal/Newspaper |
author |
K. Zwingenberger J. A. Nogueira Queiroz U. Poggensee J. E. Alencar J. Valdegunas F. Esmeralda H. Feldmeier |
author_facet |
K. Zwingenberger J. A. Nogueira Queiroz U. Poggensee J. E. Alencar J. Valdegunas F. Esmeralda H. Feldmeier |
author_sort |
K. Zwingenberger |
title |
Efficacy of oxamniquine, praziquantel and a combination of both drugs in schistosomiasis mansoni in Brazil |
title_short |
Efficacy of oxamniquine, praziquantel and a combination of both drugs in schistosomiasis mansoni in Brazil |
title_full |
Efficacy of oxamniquine, praziquantel and a combination of both drugs in schistosomiasis mansoni in Brazil |
title_fullStr |
Efficacy of oxamniquine, praziquantel and a combination of both drugs in schistosomiasis mansoni in Brazil |
title_full_unstemmed |
Efficacy of oxamniquine, praziquantel and a combination of both drugs in schistosomiasis mansoni in Brazil |
title_sort |
efficacy of oxamniquine, praziquantel and a combination of both drugs in schistosomiasis mansoni in brazil |
publisher |
Universidade de São Paulo (USP) |
publishDate |
1987 |
url |
https://doi.org/10.1590/S0036-46651987000500007 https://doaj.org/article/2e10cbf77f25491593b11c457fe9e545 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista do Instituto de Medicina Tropical de São Paulo, Vol 29, Iss 5, Pp 305-311 (1987) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46651987000500007&lng=en&tlng=en https://doaj.org/toc/1678-9946 1678-9946 doi:10.1590/S0036-46651987000500007 https://doaj.org/article/2e10cbf77f25491593b11c457fe9e545 |
op_doi |
https://doi.org/10.1590/S0036-46651987000500007 |
container_title |
Revista do Instituto de Medicina Tropical de São Paulo |
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29 |
container_issue |
5 |
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305 |
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311 |
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