Epidemiology and antimicrobial resistance of invasive non-typhoidal Salmonellosis in rural Thailand from 2006-2014.
INTRODUCTION:Invasive salmonellosis is a common cause of bloodstream infection in Southeast Asia. Limited epidemiologic and antimicrobial resistance data are available from the region. METHODS:Blood cultures performed in all 20 hospitals in the northeastern province of Nakhon Phanom (NP) and eastern...
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ftdoajarticles:oai:doaj.org/article:2e10b3bcd5b040c3a0ebd496bd2e4799 2023-05-15T15:14:12+02:00 Epidemiology and antimicrobial resistance of invasive non-typhoidal Salmonellosis in rural Thailand from 2006-2014. Toni Whistler Patranuch Sapchookul David W McCormick Ornuma Sangwichian Possawat Jorakate Sirirat Makprasert Anchalee Jatapai Sathapana Naorat Uraiwan Surin Surathinee Koosakunwat Surachai Supcharassaeng Barameht Piralam Mathew Mikoleit Henry C Baggett Julia Rhodes Christopher J Gregory 2018-08-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0006718 https://doaj.org/article/2e10b3bcd5b040c3a0ebd496bd2e4799 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC6095622?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0006718 https://doaj.org/article/2e10b3bcd5b040c3a0ebd496bd2e4799 PLoS Neglected Tropical Diseases, Vol 12, Iss 8, p e0006718 (2018) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2018 ftdoajarticles https://doi.org/10.1371/journal.pntd.0006718 2022-12-31T03:12:05Z INTRODUCTION:Invasive salmonellosis is a common cause of bloodstream infection in Southeast Asia. Limited epidemiologic and antimicrobial resistance data are available from the region. METHODS:Blood cultures performed in all 20 hospitals in the northeastern province of Nakhon Phanom (NP) and eastern province of Sa Kaeo (SK), Thailand were captured in a bloodstream infection surveillance system. Cultures were performed as clinically indicated in hospitalized patients; patients with multiple positive cultures had only the first included. Bottles were incubated using the BacT/Alert system (bioMérieux, Thailand) and isolates were identified using standard microbiological techniques; all Salmonella isolates were classified to at least the serogroup level. Antimicrobial resistance was assessed using disk diffusion. RESULTS:Salmonella was the fifth most common pathogen identified in 147,535 cultures with 525 cases (211 in Nakhon Phanom (NP) and 314 in Sa Kaeo (SK)). The overall adjusted iNTS incidence rate in NP was 4.0 cases/100,000 person-years (95% CI 3.5-4.5) and in SK 6.4 cases/100,000 person-years (95% CI 5.7-7.1; p = 0.001). The most common serogroups were C (39.4%), D (35.0%) and B (9.9%). Serogroup D predominated in NP (103/211) with 59.2% of this serogroup being Salmonella serovar Enteritidis. Serogroup C predominated in SK (166/314) with 84.3% of this serogroup being Salmonella serovar Choleraesuis. Antibiotic resistance was 68.2% (343/503) for ampicillin, 1.2% (6/482) for ciprofloxacin (or 58.1% (280/482) if both intermediate and resistant phenotypes are considered), 17.0% (87/512) for trimethoprim-sulfamethoxazole, and 12.2% (59/484) for third-generation cephalosporins (cefotaxime or ceftazidime). Multidrug resistance was seen in 99/516 isolates (19.2%). CONCLUSIONS:The NTS isolates causing bloodstream infections in rural Thailand are commonly resistant to ampicillin, cefotaxime, and TMP-SMX. Observed differences between NP and SK indicate that serogroup distribution and antibiotic resistance may ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Nakhon ENVELOPE(101.950,101.950,71.850,71.850) PLOS Neglected Tropical Diseases 12 8 e0006718 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Toni Whistler Patranuch Sapchookul David W McCormick Ornuma Sangwichian Possawat Jorakate Sirirat Makprasert Anchalee Jatapai Sathapana Naorat Uraiwan Surin Surathinee Koosakunwat Surachai Supcharassaeng Barameht Piralam Mathew Mikoleit Henry C Baggett Julia Rhodes Christopher J Gregory Epidemiology and antimicrobial resistance of invasive non-typhoidal Salmonellosis in rural Thailand from 2006-2014. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
INTRODUCTION:Invasive salmonellosis is a common cause of bloodstream infection in Southeast Asia. Limited epidemiologic and antimicrobial resistance data are available from the region. METHODS:Blood cultures performed in all 20 hospitals in the northeastern province of Nakhon Phanom (NP) and eastern province of Sa Kaeo (SK), Thailand were captured in a bloodstream infection surveillance system. Cultures were performed as clinically indicated in hospitalized patients; patients with multiple positive cultures had only the first included. Bottles were incubated using the BacT/Alert system (bioMérieux, Thailand) and isolates were identified using standard microbiological techniques; all Salmonella isolates were classified to at least the serogroup level. Antimicrobial resistance was assessed using disk diffusion. RESULTS:Salmonella was the fifth most common pathogen identified in 147,535 cultures with 525 cases (211 in Nakhon Phanom (NP) and 314 in Sa Kaeo (SK)). The overall adjusted iNTS incidence rate in NP was 4.0 cases/100,000 person-years (95% CI 3.5-4.5) and in SK 6.4 cases/100,000 person-years (95% CI 5.7-7.1; p = 0.001). The most common serogroups were C (39.4%), D (35.0%) and B (9.9%). Serogroup D predominated in NP (103/211) with 59.2% of this serogroup being Salmonella serovar Enteritidis. Serogroup C predominated in SK (166/314) with 84.3% of this serogroup being Salmonella serovar Choleraesuis. Antibiotic resistance was 68.2% (343/503) for ampicillin, 1.2% (6/482) for ciprofloxacin (or 58.1% (280/482) if both intermediate and resistant phenotypes are considered), 17.0% (87/512) for trimethoprim-sulfamethoxazole, and 12.2% (59/484) for third-generation cephalosporins (cefotaxime or ceftazidime). Multidrug resistance was seen in 99/516 isolates (19.2%). CONCLUSIONS:The NTS isolates causing bloodstream infections in rural Thailand are commonly resistant to ampicillin, cefotaxime, and TMP-SMX. Observed differences between NP and SK indicate that serogroup distribution and antibiotic resistance may ... |
format |
Article in Journal/Newspaper |
author |
Toni Whistler Patranuch Sapchookul David W McCormick Ornuma Sangwichian Possawat Jorakate Sirirat Makprasert Anchalee Jatapai Sathapana Naorat Uraiwan Surin Surathinee Koosakunwat Surachai Supcharassaeng Barameht Piralam Mathew Mikoleit Henry C Baggett Julia Rhodes Christopher J Gregory |
author_facet |
Toni Whistler Patranuch Sapchookul David W McCormick Ornuma Sangwichian Possawat Jorakate Sirirat Makprasert Anchalee Jatapai Sathapana Naorat Uraiwan Surin Surathinee Koosakunwat Surachai Supcharassaeng Barameht Piralam Mathew Mikoleit Henry C Baggett Julia Rhodes Christopher J Gregory |
author_sort |
Toni Whistler |
title |
Epidemiology and antimicrobial resistance of invasive non-typhoidal Salmonellosis in rural Thailand from 2006-2014. |
title_short |
Epidemiology and antimicrobial resistance of invasive non-typhoidal Salmonellosis in rural Thailand from 2006-2014. |
title_full |
Epidemiology and antimicrobial resistance of invasive non-typhoidal Salmonellosis in rural Thailand from 2006-2014. |
title_fullStr |
Epidemiology and antimicrobial resistance of invasive non-typhoidal Salmonellosis in rural Thailand from 2006-2014. |
title_full_unstemmed |
Epidemiology and antimicrobial resistance of invasive non-typhoidal Salmonellosis in rural Thailand from 2006-2014. |
title_sort |
epidemiology and antimicrobial resistance of invasive non-typhoidal salmonellosis in rural thailand from 2006-2014. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2018 |
url |
https://doi.org/10.1371/journal.pntd.0006718 https://doaj.org/article/2e10b3bcd5b040c3a0ebd496bd2e4799 |
long_lat |
ENVELOPE(101.950,101.950,71.850,71.850) |
geographic |
Arctic Nakhon |
geographic_facet |
Arctic Nakhon |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 12, Iss 8, p e0006718 (2018) |
op_relation |
http://europepmc.org/articles/PMC6095622?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0006718 https://doaj.org/article/2e10b3bcd5b040c3a0ebd496bd2e4799 |
op_doi |
https://doi.org/10.1371/journal.pntd.0006718 |
container_title |
PLOS Neglected Tropical Diseases |
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12 |
container_issue |
8 |
container_start_page |
e0006718 |
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1766344679882752000 |