Kaempferol Addition Increases the Antimalarial Activity of Artesunate in Experimental Mice
Kaempferol (KMF) is a member of flavonol widely found in tea, broccoli, apples, strawberries, and beans. It has been demonstrated to present several pharmacological properties with potent antimalarial activity against Plasmodium berghei-infected mice. Hence, the search for a safe and new antimalaria...
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ftdoajarticles:oai:doaj.org/article:2dd8bb1f1ccd473c852fd867bb860b2f 2023-05-15T15:11:18+02:00 Kaempferol Addition Increases the Antimalarial Activity of Artesunate in Experimental Mice Sakaewan Ounjaijean Nattida Benjasak Suchanan Sae-lao Voravuth Somsak 2020-01-01T00:00:00Z https://doi.org/10.1155/2020/6165928 https://doaj.org/article/2dd8bb1f1ccd473c852fd867bb860b2f EN eng Hindawi Limited http://dx.doi.org/10.1155/2020/6165928 https://doaj.org/toc/1687-9686 https://doaj.org/toc/1687-9694 1687-9686 1687-9694 doi:10.1155/2020/6165928 https://doaj.org/article/2dd8bb1f1ccd473c852fd867bb860b2f Journal of Tropical Medicine, Vol 2020 (2020) Arctic medicine. Tropical medicine RC955-962 article 2020 ftdoajarticles https://doi.org/10.1155/2020/6165928 2022-12-31T09:05:11Z Kaempferol (KMF) is a member of flavonol widely found in tea, broccoli, apples, strawberries, and beans. It has been demonstrated to present several pharmacological properties with potent antimalarial activity against Plasmodium berghei-infected mice. Hence, the search for a safe and new antimalarial compound with combinations to delay the development of resistance was the aim of this study. Thus, the therapeutic effect of the combination of KMF and artesunate (ART) in P. berghei-infected mice was evaluated. Combination of KMF and ART in P. berghei ANKA- (PbANKA-) infected ICR mice in a fixed-ratio combination (1 : 1) and fractions of their median effective dose (ED50) was also investigated using the standard 4-day suppressive test. The ED50 levels of KMF and ART in mice infected with PbANKA were 20.06 ± 2.65 and 6.06 ± 1.33 mg/kg, respectively. Moreover, KMF showed promising synergistic combination with ART at the doses of their ED50 and fixed-ratio combination (1 : 1) of their ED50 of 1/2 with combination index (CI) values of 0.86 and 0.47, respectively. Additionally, KMF, ART, and its combination at the doses of their ED50 and fixed-ratio combination (1 : 1) of their ED50 of 1/2 also presented significantly (P<0.001) prolonged mean survival time (MST). The findings of this study showed that a combination of KMF and ART enhanced the antimalarial activity of ART and prolonged MST. This study supports the basis for the selection of KMF as a prospective compound for further consideration as a partner drug for ART. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Journal of Tropical Medicine 2020 1 4 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
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English |
topic |
Arctic medicine. Tropical medicine RC955-962 |
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Arctic medicine. Tropical medicine RC955-962 Sakaewan Ounjaijean Nattida Benjasak Suchanan Sae-lao Voravuth Somsak Kaempferol Addition Increases the Antimalarial Activity of Artesunate in Experimental Mice |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 |
description |
Kaempferol (KMF) is a member of flavonol widely found in tea, broccoli, apples, strawberries, and beans. It has been demonstrated to present several pharmacological properties with potent antimalarial activity against Plasmodium berghei-infected mice. Hence, the search for a safe and new antimalarial compound with combinations to delay the development of resistance was the aim of this study. Thus, the therapeutic effect of the combination of KMF and artesunate (ART) in P. berghei-infected mice was evaluated. Combination of KMF and ART in P. berghei ANKA- (PbANKA-) infected ICR mice in a fixed-ratio combination (1 : 1) and fractions of their median effective dose (ED50) was also investigated using the standard 4-day suppressive test. The ED50 levels of KMF and ART in mice infected with PbANKA were 20.06 ± 2.65 and 6.06 ± 1.33 mg/kg, respectively. Moreover, KMF showed promising synergistic combination with ART at the doses of their ED50 and fixed-ratio combination (1 : 1) of their ED50 of 1/2 with combination index (CI) values of 0.86 and 0.47, respectively. Additionally, KMF, ART, and its combination at the doses of their ED50 and fixed-ratio combination (1 : 1) of their ED50 of 1/2 also presented significantly (P<0.001) prolonged mean survival time (MST). The findings of this study showed that a combination of KMF and ART enhanced the antimalarial activity of ART and prolonged MST. This study supports the basis for the selection of KMF as a prospective compound for further consideration as a partner drug for ART. |
format |
Article in Journal/Newspaper |
author |
Sakaewan Ounjaijean Nattida Benjasak Suchanan Sae-lao Voravuth Somsak |
author_facet |
Sakaewan Ounjaijean Nattida Benjasak Suchanan Sae-lao Voravuth Somsak |
author_sort |
Sakaewan Ounjaijean |
title |
Kaempferol Addition Increases the Antimalarial Activity of Artesunate in Experimental Mice |
title_short |
Kaempferol Addition Increases the Antimalarial Activity of Artesunate in Experimental Mice |
title_full |
Kaempferol Addition Increases the Antimalarial Activity of Artesunate in Experimental Mice |
title_fullStr |
Kaempferol Addition Increases the Antimalarial Activity of Artesunate in Experimental Mice |
title_full_unstemmed |
Kaempferol Addition Increases the Antimalarial Activity of Artesunate in Experimental Mice |
title_sort |
kaempferol addition increases the antimalarial activity of artesunate in experimental mice |
publisher |
Hindawi Limited |
publishDate |
2020 |
url |
https://doi.org/10.1155/2020/6165928 https://doaj.org/article/2dd8bb1f1ccd473c852fd867bb860b2f |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Journal of Tropical Medicine, Vol 2020 (2020) |
op_relation |
http://dx.doi.org/10.1155/2020/6165928 https://doaj.org/toc/1687-9686 https://doaj.org/toc/1687-9694 1687-9686 1687-9694 doi:10.1155/2020/6165928 https://doaj.org/article/2dd8bb1f1ccd473c852fd867bb860b2f |
op_doi |
https://doi.org/10.1155/2020/6165928 |
container_title |
Journal of Tropical Medicine |
container_volume |
2020 |
container_start_page |
1 |
op_container_end_page |
4 |
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1766342181069520896 |