Heritability and complex segregation analysis of diabetes mellitus in American Eskimo Dogs
Abstract Background Heritability and mode of inheritance of spontaneous diabetes mellitus (DM) in American Eskimo Dogs (AED) are unknown. Objective Investigate the heritability and mode of inheritance of DM in AED. Animals An extended family of AED including 71 AED without DM, 47 AED with an unknown...
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ftdoajarticles:oai:doaj.org/article:2d6d166465c5406895f808119ee3d79c 2023-05-15T16:07:26+02:00 Heritability and complex segregation analysis of diabetes mellitus in American Eskimo Dogs Stephen V. Cai Thomas R. Famula Anita M. Oberbauer Rebecka S. Hess 2019-09-01T00:00:00Z https://doi.org/10.1111/jvim.15570 https://doaj.org/article/2d6d166465c5406895f808119ee3d79c EN eng Wiley https://doi.org/10.1111/jvim.15570 https://doaj.org/toc/0891-6640 https://doaj.org/toc/1939-1676 1939-1676 0891-6640 doi:10.1111/jvim.15570 https://doaj.org/article/2d6d166465c5406895f808119ee3d79c Journal of Veterinary Internal Medicine, Vol 33, Iss 5, Pp 1926-1934 (2019) canine genetic risk non‐Mendelian polygenic Veterinary medicine SF600-1100 article 2019 ftdoajarticles https://doi.org/10.1111/jvim.15570 2022-12-30T19:49:25Z Abstract Background Heritability and mode of inheritance of spontaneous diabetes mellitus (DM) in American Eskimo Dogs (AED) are unknown. Objective Investigate the heritability and mode of inheritance of DM in AED. Animals An extended family of AED including 71 AED without DM, 47 AED with an unknown phenotype, and 38 AED with spontaneous DM. Methods Retrospective evaluation of inheritance. A logistic regression model was formulated to evaluate the heritability of DM, including effects of sex and neuter status. Subsequently, complex segregation analysis was employed to investigate the inheritance pattern of DM in AED. Six plausible models were considered, and the Akaike Information Criterion was used to determine the best of the biologically feasible models of inheritance of DM in AED. Results Heritability of DM in AED is estimated at 0.62 (95% posterior interval 0.01‐0.99). Predicted DM probabilities for neutered females (NF), intact females (IF), neutered males (NM), and intact males (IM) were 0.76, 0.11, 0.63, and 0.12, respectively. There was no overlap between the 95% posterior intervals of disease probabilities in NF and IF or in NF and IM. Complex segregation analysis suggested that the mode of inheritance of DM in AED is polygenic, with no evidence for a single gene of large effect. Conclusions and Clinical Importance The estimated heritability of DM in AED is high but has low precision. Diabetes mellitus transmission in AED appears to follow a polygenic inheritance. Breeders could successfully implement a breeding program to decrease the incidence of DM in AED. Article in Journal/Newspaper eskimo* Directory of Open Access Journals: DOAJ Articles Journal of Veterinary Internal Medicine 33 5 1926 1934 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
canine genetic risk non‐Mendelian polygenic Veterinary medicine SF600-1100 |
spellingShingle |
canine genetic risk non‐Mendelian polygenic Veterinary medicine SF600-1100 Stephen V. Cai Thomas R. Famula Anita M. Oberbauer Rebecka S. Hess Heritability and complex segregation analysis of diabetes mellitus in American Eskimo Dogs |
topic_facet |
canine genetic risk non‐Mendelian polygenic Veterinary medicine SF600-1100 |
description |
Abstract Background Heritability and mode of inheritance of spontaneous diabetes mellitus (DM) in American Eskimo Dogs (AED) are unknown. Objective Investigate the heritability and mode of inheritance of DM in AED. Animals An extended family of AED including 71 AED without DM, 47 AED with an unknown phenotype, and 38 AED with spontaneous DM. Methods Retrospective evaluation of inheritance. A logistic regression model was formulated to evaluate the heritability of DM, including effects of sex and neuter status. Subsequently, complex segregation analysis was employed to investigate the inheritance pattern of DM in AED. Six plausible models were considered, and the Akaike Information Criterion was used to determine the best of the biologically feasible models of inheritance of DM in AED. Results Heritability of DM in AED is estimated at 0.62 (95% posterior interval 0.01‐0.99). Predicted DM probabilities for neutered females (NF), intact females (IF), neutered males (NM), and intact males (IM) were 0.76, 0.11, 0.63, and 0.12, respectively. There was no overlap between the 95% posterior intervals of disease probabilities in NF and IF or in NF and IM. Complex segregation analysis suggested that the mode of inheritance of DM in AED is polygenic, with no evidence for a single gene of large effect. Conclusions and Clinical Importance The estimated heritability of DM in AED is high but has low precision. Diabetes mellitus transmission in AED appears to follow a polygenic inheritance. Breeders could successfully implement a breeding program to decrease the incidence of DM in AED. |
format |
Article in Journal/Newspaper |
author |
Stephen V. Cai Thomas R. Famula Anita M. Oberbauer Rebecka S. Hess |
author_facet |
Stephen V. Cai Thomas R. Famula Anita M. Oberbauer Rebecka S. Hess |
author_sort |
Stephen V. Cai |
title |
Heritability and complex segregation analysis of diabetes mellitus in American Eskimo Dogs |
title_short |
Heritability and complex segregation analysis of diabetes mellitus in American Eskimo Dogs |
title_full |
Heritability and complex segregation analysis of diabetes mellitus in American Eskimo Dogs |
title_fullStr |
Heritability and complex segregation analysis of diabetes mellitus in American Eskimo Dogs |
title_full_unstemmed |
Heritability and complex segregation analysis of diabetes mellitus in American Eskimo Dogs |
title_sort |
heritability and complex segregation analysis of diabetes mellitus in american eskimo dogs |
publisher |
Wiley |
publishDate |
2019 |
url |
https://doi.org/10.1111/jvim.15570 https://doaj.org/article/2d6d166465c5406895f808119ee3d79c |
genre |
eskimo* |
genre_facet |
eskimo* |
op_source |
Journal of Veterinary Internal Medicine, Vol 33, Iss 5, Pp 1926-1934 (2019) |
op_relation |
https://doi.org/10.1111/jvim.15570 https://doaj.org/toc/0891-6640 https://doaj.org/toc/1939-1676 1939-1676 0891-6640 doi:10.1111/jvim.15570 https://doaj.org/article/2d6d166465c5406895f808119ee3d79c |
op_doi |
https://doi.org/10.1111/jvim.15570 |
container_title |
Journal of Veterinary Internal Medicine |
container_volume |
33 |
container_issue |
5 |
container_start_page |
1926 |
op_container_end_page |
1934 |
_version_ |
1766403547153301504 |