Evolution of sarcoma 180 (ascitic tumor) in mice infected with Schistosoma mansoni

Mice infected with 60 cercariae of Schistosoma mansoni were more resistant to the sarcoma 180 ascites tumor. Tumor inoculation was performed 50 days after schistosoma infection and the animals were observed and weighed at 48 hours intervals for development and progression of malignancy. In infected...

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Main Authors: Fausto Edmundo Lima Pereira, Pedro Raso, Paulo Marcos Zech Coelho
Format: Article in Journal/Newspaper
Language:English
Published: Sociedade Brasileira de Medicina Tropical (SBMT) 1986
Subjects:
Online Access:https://doaj.org/article/2d6a0aa96053454d860328ee8f4a4182
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author Fausto Edmundo Lima Pereira
Pedro Raso
Paulo Marcos Zech Coelho
author_facet Fausto Edmundo Lima Pereira
Pedro Raso
Paulo Marcos Zech Coelho
author_sort Fausto Edmundo Lima Pereira
collection Directory of Open Access Journals: DOAJ Articles
description Mice infected with 60 cercariae of Schistosoma mansoni were more resistant to the sarcoma 180 ascites tumor. Tumor inoculation was performed 50 days after schistosoma infection and the animals were observed and weighed at 48 hours intervals for development and progression of malignancy. In infected mice the weight gain (ascites formation) started later and was shorter than in uninfected Controls. Also, the number of tumor cells into the peritoneal cavity 72h after tumor implantation was shorter in infected group than incontrols. This in creased resistance against a transplantable tumor probably is related to the effect of endotoxin on tumoricidal activity of macrophages activated by the infection. The immunodepression induced by Schistosoma mansoni infection enhances the proliferation of endogenous bacteria increasing the amount of endotoxin absorbed from the gut. Camundongos infectados com 60 cercárias de Schistosoma mansoni tomaram-se mais resistentes ao sarcoma 180 na forma de tumor ascítico. A inoculação das células tumorais foi feita no 50º dia de infecção e a evolução do tumor foi acompanhada através dapesagem dos animais com intervalos de 48 horas. Nos camundongos infectados o ganho de peso (formação da ascite) começou mais tarde e foi menor do que nos controles não infectados. Também o número de células tumorais na cavidade peritoneal 72 horas após a implantação do tumor foi menor no grupo infectado. Este aumento de resistência a um tumor transplantávelpossivelmente está relacionado ao efeito de endotoxinas sobre a atividade tumoricida dos macrofagos ativados pela infecção. A imunossupressão induzida pela infecção favorece a proliferação de bactérias da flora endógena aumentando a quantidade de endotoxinas absorvidas pelo intestino.
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op_source Revista da Sociedade Brasileira de Medicina Tropical, Vol 19, Iss 1, Pp 39-42 (1986)
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spelling ftdoajarticles:oai:doaj.org/article:2d6a0aa96053454d860328ee8f4a4182 2025-01-16T20:45:02+00:00 Evolution of sarcoma 180 (ascitic tumor) in mice infected with Schistosoma mansoni Fausto Edmundo Lima Pereira Pedro Raso Paulo Marcos Zech Coelho 1986-03-01T00:00:00Z https://doaj.org/article/2d6a0aa96053454d860328ee8f4a4182 EN eng Sociedade Brasileira de Medicina Tropical (SBMT) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86821986000100009 https://doaj.org/toc/0037-8682 https://doaj.org/toc/1678-9849 0037-8682 1678-9849 https://doaj.org/article/2d6a0aa96053454d860328ee8f4a4182 Revista da Sociedade Brasileira de Medicina Tropical, Vol 19, Iss 1, Pp 39-42 (1986) Esquistossomose experimental Sarcoma 180 Esquistossomose e Câncer Experimental Schistosomiasis Schistosomiasis and cancer Arctic medicine. Tropical medicine RC955-962 article 1986 ftdoajarticles 2022-12-31T02:02:52Z Mice infected with 60 cercariae of Schistosoma mansoni were more resistant to the sarcoma 180 ascites tumor. Tumor inoculation was performed 50 days after schistosoma infection and the animals were observed and weighed at 48 hours intervals for development and progression of malignancy. In infected mice the weight gain (ascites formation) started later and was shorter than in uninfected Controls. Also, the number of tumor cells into the peritoneal cavity 72h after tumor implantation was shorter in infected group than incontrols. This in creased resistance against a transplantable tumor probably is related to the effect of endotoxin on tumoricidal activity of macrophages activated by the infection. The immunodepression induced by Schistosoma mansoni infection enhances the proliferation of endogenous bacteria increasing the amount of endotoxin absorbed from the gut. Camundongos infectados com 60 cercárias de Schistosoma mansoni tomaram-se mais resistentes ao sarcoma 180 na forma de tumor ascítico. A inoculação das células tumorais foi feita no 50º dia de infecção e a evolução do tumor foi acompanhada através dapesagem dos animais com intervalos de 48 horas. Nos camundongos infectados o ganho de peso (formação da ascite) começou mais tarde e foi menor do que nos controles não infectados. Também o número de células tumorais na cavidade peritoneal 72 horas após a implantação do tumor foi menor no grupo infectado. Este aumento de resistência a um tumor transplantávelpossivelmente está relacionado ao efeito de endotoxinas sobre a atividade tumoricida dos macrofagos ativados pela infecção. A imunossupressão induzida pela infecção favorece a proliferação de bactérias da flora endógena aumentando a quantidade de endotoxinas absorvidas pelo intestino. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic
spellingShingle Esquistossomose experimental
Sarcoma 180
Esquistossomose e Câncer
Experimental Schistosomiasis
Schistosomiasis and cancer
Arctic medicine. Tropical medicine
RC955-962
Fausto Edmundo Lima Pereira
Pedro Raso
Paulo Marcos Zech Coelho
Evolution of sarcoma 180 (ascitic tumor) in mice infected with Schistosoma mansoni
title Evolution of sarcoma 180 (ascitic tumor) in mice infected with Schistosoma mansoni
title_full Evolution of sarcoma 180 (ascitic tumor) in mice infected with Schistosoma mansoni
title_fullStr Evolution of sarcoma 180 (ascitic tumor) in mice infected with Schistosoma mansoni
title_full_unstemmed Evolution of sarcoma 180 (ascitic tumor) in mice infected with Schistosoma mansoni
title_short Evolution of sarcoma 180 (ascitic tumor) in mice infected with Schistosoma mansoni
title_sort evolution of sarcoma 180 (ascitic tumor) in mice infected with schistosoma mansoni
topic Esquistossomose experimental
Sarcoma 180
Esquistossomose e Câncer
Experimental Schistosomiasis
Schistosomiasis and cancer
Arctic medicine. Tropical medicine
RC955-962
topic_facet Esquistossomose experimental
Sarcoma 180
Esquistossomose e Câncer
Experimental Schistosomiasis
Schistosomiasis and cancer
Arctic medicine. Tropical medicine
RC955-962
url https://doaj.org/article/2d6a0aa96053454d860328ee8f4a4182