Exploring the feasibility of introducing triple artemisinin-based combination therapy in the malaria treatment policy in Vietnam

• Published in: Malaria Journal
• Main Authors: Van Anh Thi Cao, Thieu Quang Nguyen, Duong Le Quyen, Wouter P. C. Boon, Ellen H. M. Moors, Arjen M. Dondorp, Freek de Haan, Chanaki Amaratunga
• Format: Article in Journal/Newspaper
• Language: English
• Published: BMC 2023
• Subjects: Triple artemisinin-based combination therapy (TACT); Introduction strategies; Drug resistance; Arctic medicine. Tropical medicine; RC955-962; Infectious and parasitic diseases; RC109-216; Arctic
• Online Access: https://doi.org/10.1186/s12936-023-04763-4; https://doaj.org/article/2d66ede009644e0a8a8fb62360d26d0d

Abstract Background This study investigates the processes regarding changing malaria treatment policies in Vietnam. Moreover, it explores the feasibility of introducing triple artemisinin-based combination therapy (TACT) in Vietnam to support the national malaria control and elimination plan. Methods Data were collected via 12 in-depth interviews with key stakeholders, combined with a review of policy documents. Results TACT is considered as a useful backup strategy in case future treatment failures with current artemisinin-based combination therapy (ACT) would occur. Moreover, TACT is also considered as a promising strategy to prevent the re-establishment of malaria. However, regulatory procedures and implementation timelines for TACT were expected to be lengthy. Therefore, strategies to engage national decision-makers, regulators, and suppliers should be initiated soon, stipulating the benefits of TACT deployment. In Vietnam, a procedure to apply for an import permit without registration that has previously been applied to the introduction of artesunate-pyronaridine was proposed to accelerate the introduction of TACT. Global-level support through the World Health Organization recommendations and prequalification were considered critical for supporting the introduction of TACT in Vietnam. Conclusions Appropriate approach strategies and early stakeholder engagement will be needed to accelerate the introduction of TACT in Vietnam.