Survival time among patients who were diagnosed with tuberculosis, the precocious deaths and associated factors in southern Brazil
Abstract Background A diagnosis of tuberculosis (TB) does not mean that the disease will be treated successfully, since death may occur even among those who are known to the health services. Here, we aimed to analyze patient survival time from the diagnosis of TB to death, precocious deaths, and ass...
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ftdoajarticles:oai:doaj.org/article:2d4c32e6d0c14756ac2680537630287b 2023-05-15T15:13:33+02:00 Survival time among patients who were diagnosed with tuberculosis, the precocious deaths and associated factors in southern Brazil Danielle Talita dos Santos Luiz Henrique Arroyo Yan Mathias Alves Luana Seles Alves Thais Zamboni Berra Juliane de Almeida Crispim Josilene Dália Alves Denisse Andrea Cartagena Ramos Jonas Bodini Alonso Ivaneliza Simionato de Assis Antônio Vieira Ramos Elma Mathias Dessunti Ione Carvalho Pinto Pedro Fredemir Palha Ricardo Alexandre Arcêncio Carla Nunes 2021-04-01T00:00:00Z https://doi.org/10.1186/s41182-021-00320-4 https://doaj.org/article/2d4c32e6d0c14756ac2680537630287b EN eng BMC https://doi.org/10.1186/s41182-021-00320-4 https://doaj.org/toc/1349-4147 doi:10.1186/s41182-021-00320-4 1349-4147 https://doaj.org/article/2d4c32e6d0c14756ac2680537630287b Tropical Medicine and Health, Vol 49, Iss 1, Pp 1-14 (2021) Survival analysis Tuberculosis HIV Mortality Risk factors Arctic medicine. Tropical medicine RC955-962 article 2021 ftdoajarticles https://doi.org/10.1186/s41182-021-00320-4 2022-12-31T06:00:32Z Abstract Background A diagnosis of tuberculosis (TB) does not mean that the disease will be treated successfully, since death may occur even among those who are known to the health services. Here, we aimed to analyze patient survival time from the diagnosis of TB to death, precocious deaths, and associated factors in southern Brazil. Methods We conducted a longitudinal study with patients who were diagnosed with TB and who died due to the disease between 2008 and 2015 in southern Brazil. The starting point for measuring survival time was the patient’s diagnosis date. Techniques for survival analysis were employed, including the Kaplan-Meier test and Cox’s regression. A mixed-effect model was applied for identifying the associated factors to precocious deaths. Hazard ratio (HR) and odds ratio (OR) with 95% confidence intervals (95% CI) were estimated. We defined p value <0.05 as statistically significant for all statistics applied. Results One hundred forty-six patients were included in the survival analysis, observing a median survival time of 23.5 days. We observed that alcoholism (HR=1.55, 95% CI=1.04-2.30) and being male (HR=6.49, 95% CI=1.03-2.68) were associated with death. The chance of precocious death within 60 days was 10.48 times greater than the chance of early death within 30 days. Conclusion Most of the deaths occurred within 2 months after the diagnosis, during the intensive phase of the treatment. The use of alcohol and gender were associated with death, revealing inequality between men and women. This study advanced knowledge regarding the vulnerability associated with mortality. These findings must be addressed to fill a gap in the care cascades for active TB and ensure equity in health. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Meier ENVELOPE(-45.900,-45.900,-60.633,-60.633) Tropical Medicine and Health 49 1 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Survival analysis Tuberculosis HIV Mortality Risk factors Arctic medicine. Tropical medicine RC955-962 |
spellingShingle |
Survival analysis Tuberculosis HIV Mortality Risk factors Arctic medicine. Tropical medicine RC955-962 Danielle Talita dos Santos Luiz Henrique Arroyo Yan Mathias Alves Luana Seles Alves Thais Zamboni Berra Juliane de Almeida Crispim Josilene Dália Alves Denisse Andrea Cartagena Ramos Jonas Bodini Alonso Ivaneliza Simionato de Assis Antônio Vieira Ramos Elma Mathias Dessunti Ione Carvalho Pinto Pedro Fredemir Palha Ricardo Alexandre Arcêncio Carla Nunes Survival time among patients who were diagnosed with tuberculosis, the precocious deaths and associated factors in southern Brazil |
topic_facet |
Survival analysis Tuberculosis HIV Mortality Risk factors Arctic medicine. Tropical medicine RC955-962 |
description |
Abstract Background A diagnosis of tuberculosis (TB) does not mean that the disease will be treated successfully, since death may occur even among those who are known to the health services. Here, we aimed to analyze patient survival time from the diagnosis of TB to death, precocious deaths, and associated factors in southern Brazil. Methods We conducted a longitudinal study with patients who were diagnosed with TB and who died due to the disease between 2008 and 2015 in southern Brazil. The starting point for measuring survival time was the patient’s diagnosis date. Techniques for survival analysis were employed, including the Kaplan-Meier test and Cox’s regression. A mixed-effect model was applied for identifying the associated factors to precocious deaths. Hazard ratio (HR) and odds ratio (OR) with 95% confidence intervals (95% CI) were estimated. We defined p value <0.05 as statistically significant for all statistics applied. Results One hundred forty-six patients were included in the survival analysis, observing a median survival time of 23.5 days. We observed that alcoholism (HR=1.55, 95% CI=1.04-2.30) and being male (HR=6.49, 95% CI=1.03-2.68) were associated with death. The chance of precocious death within 60 days was 10.48 times greater than the chance of early death within 30 days. Conclusion Most of the deaths occurred within 2 months after the diagnosis, during the intensive phase of the treatment. The use of alcohol and gender were associated with death, revealing inequality between men and women. This study advanced knowledge regarding the vulnerability associated with mortality. These findings must be addressed to fill a gap in the care cascades for active TB and ensure equity in health. |
format |
Article in Journal/Newspaper |
author |
Danielle Talita dos Santos Luiz Henrique Arroyo Yan Mathias Alves Luana Seles Alves Thais Zamboni Berra Juliane de Almeida Crispim Josilene Dália Alves Denisse Andrea Cartagena Ramos Jonas Bodini Alonso Ivaneliza Simionato de Assis Antônio Vieira Ramos Elma Mathias Dessunti Ione Carvalho Pinto Pedro Fredemir Palha Ricardo Alexandre Arcêncio Carla Nunes |
author_facet |
Danielle Talita dos Santos Luiz Henrique Arroyo Yan Mathias Alves Luana Seles Alves Thais Zamboni Berra Juliane de Almeida Crispim Josilene Dália Alves Denisse Andrea Cartagena Ramos Jonas Bodini Alonso Ivaneliza Simionato de Assis Antônio Vieira Ramos Elma Mathias Dessunti Ione Carvalho Pinto Pedro Fredemir Palha Ricardo Alexandre Arcêncio Carla Nunes |
author_sort |
Danielle Talita dos Santos |
title |
Survival time among patients who were diagnosed with tuberculosis, the precocious deaths and associated factors in southern Brazil |
title_short |
Survival time among patients who were diagnosed with tuberculosis, the precocious deaths and associated factors in southern Brazil |
title_full |
Survival time among patients who were diagnosed with tuberculosis, the precocious deaths and associated factors in southern Brazil |
title_fullStr |
Survival time among patients who were diagnosed with tuberculosis, the precocious deaths and associated factors in southern Brazil |
title_full_unstemmed |
Survival time among patients who were diagnosed with tuberculosis, the precocious deaths and associated factors in southern Brazil |
title_sort |
survival time among patients who were diagnosed with tuberculosis, the precocious deaths and associated factors in southern brazil |
publisher |
BMC |
publishDate |
2021 |
url |
https://doi.org/10.1186/s41182-021-00320-4 https://doaj.org/article/2d4c32e6d0c14756ac2680537630287b |
long_lat |
ENVELOPE(-45.900,-45.900,-60.633,-60.633) |
geographic |
Arctic Meier |
geographic_facet |
Arctic Meier |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Tropical Medicine and Health, Vol 49, Iss 1, Pp 1-14 (2021) |
op_relation |
https://doi.org/10.1186/s41182-021-00320-4 https://doaj.org/toc/1349-4147 doi:10.1186/s41182-021-00320-4 1349-4147 https://doaj.org/article/2d4c32e6d0c14756ac2680537630287b |
op_doi |
https://doi.org/10.1186/s41182-021-00320-4 |
container_title |
Tropical Medicine and Health |
container_volume |
49 |
container_issue |
1 |
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1766344094202724352 |