Transmission of malaria and genotypic variability of Plasmodium falciparum on the Island of Annobon (Equatorial Guinea)
Abstract Background Malaria transmission in Equatorial Guinea and its space-time variability has been widely studied, but there is not much information about the transmission of malaria on the small island of Annobon. In 2004, two transversal studies were carried out to establish the malaria transmi...
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ftdoajarticles:oai:doaj.org/article:2d255e2f500a4f468dfd13b34be25f06 2023-05-15T15:15:15+02:00 Transmission of malaria and genotypic variability of Plasmodium falciparum on the Island of Annobon (Equatorial Guinea) Ondo Melchor Nzambo Sisinio Bobuakasi Leonardo Descalzo Miguel de Lucio Aida Berzosa Pedro Cano Jorge Buatiche Jesus N Nseng Gloria Benito Agustin 2007-10-01T00:00:00Z https://doi.org/10.1186/1475-2875-6-141 https://doaj.org/article/2d255e2f500a4f468dfd13b34be25f06 EN eng BMC http://www.malariajournal.com/content/6/1/141 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-6-141 1475-2875 https://doaj.org/article/2d255e2f500a4f468dfd13b34be25f06 Malaria Journal, Vol 6, Iss 1, p 141 (2007) Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2007 ftdoajarticles https://doi.org/10.1186/1475-2875-6-141 2022-12-31T05:01:16Z Abstract Background Malaria transmission in Equatorial Guinea and its space-time variability has been widely studied, but there is not much information about the transmission of malaria on the small island of Annobon. In 2004, two transversal studies were carried out to establish the malaria transmission pattern on Annobon and analyse the circulating Plasmodium falciparum allelic forms. Methods A blood sample was taken from the selected children in order to determine Plasmodium infection by microscopical examination and by semi-nested multiplex PCR. The diversity of P. falciparum circulating alleles was studied on the basis of the genes encoding for the merozoite surface proteins, MSP-1 and MSP-2 of P. falciparum . Results The crude parasite rate was 17% during the dry season and 60% during the rainy season. The percentage of children sleeping under a bed net was over 80% in the two surveys. During the rainy season, 33.3% of the children surveyed were anaemic at the time of the study. No association was found between the crude parasite rate, the use of bed nets and gender, and anaemia. However, children between five and nine years of age were five times less at risk of being anaemic than those aged less than one year. A total of 28 populations of the three allelic families of the msp-1 gene were identified and 39 of the msp-2 gene. The variability of circulating allelic populations is significantly higher in the rainy than in the dry season, although the multiplicity of infections is similar in both, 2.2 and 1.9 respectively. Conclusion Based on the high degree of geographical isolation of the Annobon population and the apparent marked seasonality of the transmission, it is feasible to believe that malaria can be well controlled from this small African island. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 6 1 |
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Directory of Open Access Journals: DOAJ Articles |
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English |
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Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
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Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Ondo Melchor Nzambo Sisinio Bobuakasi Leonardo Descalzo Miguel de Lucio Aida Berzosa Pedro Cano Jorge Buatiche Jesus N Nseng Gloria Benito Agustin Transmission of malaria and genotypic variability of Plasmodium falciparum on the Island of Annobon (Equatorial Guinea) |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background Malaria transmission in Equatorial Guinea and its space-time variability has been widely studied, but there is not much information about the transmission of malaria on the small island of Annobon. In 2004, two transversal studies were carried out to establish the malaria transmission pattern on Annobon and analyse the circulating Plasmodium falciparum allelic forms. Methods A blood sample was taken from the selected children in order to determine Plasmodium infection by microscopical examination and by semi-nested multiplex PCR. The diversity of P. falciparum circulating alleles was studied on the basis of the genes encoding for the merozoite surface proteins, MSP-1 and MSP-2 of P. falciparum . Results The crude parasite rate was 17% during the dry season and 60% during the rainy season. The percentage of children sleeping under a bed net was over 80% in the two surveys. During the rainy season, 33.3% of the children surveyed were anaemic at the time of the study. No association was found between the crude parasite rate, the use of bed nets and gender, and anaemia. However, children between five and nine years of age were five times less at risk of being anaemic than those aged less than one year. A total of 28 populations of the three allelic families of the msp-1 gene were identified and 39 of the msp-2 gene. The variability of circulating allelic populations is significantly higher in the rainy than in the dry season, although the multiplicity of infections is similar in both, 2.2 and 1.9 respectively. Conclusion Based on the high degree of geographical isolation of the Annobon population and the apparent marked seasonality of the transmission, it is feasible to believe that malaria can be well controlled from this small African island. |
format |
Article in Journal/Newspaper |
author |
Ondo Melchor Nzambo Sisinio Bobuakasi Leonardo Descalzo Miguel de Lucio Aida Berzosa Pedro Cano Jorge Buatiche Jesus N Nseng Gloria Benito Agustin |
author_facet |
Ondo Melchor Nzambo Sisinio Bobuakasi Leonardo Descalzo Miguel de Lucio Aida Berzosa Pedro Cano Jorge Buatiche Jesus N Nseng Gloria Benito Agustin |
author_sort |
Ondo Melchor |
title |
Transmission of malaria and genotypic variability of Plasmodium falciparum on the Island of Annobon (Equatorial Guinea) |
title_short |
Transmission of malaria and genotypic variability of Plasmodium falciparum on the Island of Annobon (Equatorial Guinea) |
title_full |
Transmission of malaria and genotypic variability of Plasmodium falciparum on the Island of Annobon (Equatorial Guinea) |
title_fullStr |
Transmission of malaria and genotypic variability of Plasmodium falciparum on the Island of Annobon (Equatorial Guinea) |
title_full_unstemmed |
Transmission of malaria and genotypic variability of Plasmodium falciparum on the Island of Annobon (Equatorial Guinea) |
title_sort |
transmission of malaria and genotypic variability of plasmodium falciparum on the island of annobon (equatorial guinea) |
publisher |
BMC |
publishDate |
2007 |
url |
https://doi.org/10.1186/1475-2875-6-141 https://doaj.org/article/2d255e2f500a4f468dfd13b34be25f06 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 6, Iss 1, p 141 (2007) |
op_relation |
http://www.malariajournal.com/content/6/1/141 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-6-141 1475-2875 https://doaj.org/article/2d255e2f500a4f468dfd13b34be25f06 |
op_doi |
https://doi.org/10.1186/1475-2875-6-141 |
container_title |
Malaria Journal |
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6 |
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1 |
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1766345623266656256 |