Vasoprotective effects of rice bran water extract on rats fed with high-fat diet
Objective: To elucidate the protective effects of rice bran water extract on the expression of endothelial nitric oxide synthase (eNOS), nuclear factor-kappa B (NF-κB), and a cluster of differentiation 36 (CD36) in the vasculature of high-fat diet-fed rats. Methods: Male Sprague-Dawley rats were div...
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Wolters Kluwer Medknow Publications
2016
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ftdoajarticles:oai:doaj.org/article:2d1a63a10c874145aaea8283f4fcc578 2023-05-15T15:13:51+02:00 Vasoprotective effects of rice bran water extract on rats fed with high-fat diet Narongsuk Munkong Pintusorn Hansakul Bhornprom Yoysungnoen Ariyaphong Wongnoppavich Seewaboon Sireeratawong Noppamat Kaendee Nusiri Lerdvuthisopon 2016-09-01T00:00:00Z https://doi.org/10.1016/j.apjtb.2016.07.009 https://doaj.org/article/2d1a63a10c874145aaea8283f4fcc578 EN eng Wolters Kluwer Medknow Publications http://www.sciencedirect.com/science/article/pii/S2221169115310285 https://doaj.org/toc/2221-1691 2221-1691 doi:10.1016/j.apjtb.2016.07.009 https://doaj.org/article/2d1a63a10c874145aaea8283f4fcc578 Asian Pacific Journal of Tropical Biomedicine, Vol 6, Iss 9, Pp 778-784 (2016) Rice bran Metabolic syndrome Cardiovascular disease Endothelial nitric oxide synthase Nuclear factor-kappa B Cluster of differentiation 36 Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 article 2016 ftdoajarticles https://doi.org/10.1016/j.apjtb.2016.07.009 2022-12-30T20:54:36Z Objective: To elucidate the protective effects of rice bran water extract on the expression of endothelial nitric oxide synthase (eNOS), nuclear factor-kappa B (NF-κB), and a cluster of differentiation 36 (CD36) in the vasculature of high-fat diet-fed rats. Methods: Male Sprague-Dawley rats were divided into three groups. Group I served as control, Group II was treated with high-fat diet, and Group III was treated with high-fat diet and rice bran water extract at 2205 mg/kg/day. After four weeks, the metabolic parameters, malondialdehyde as a marker of oxidative stress, and histological features of the aorta were evaluated. The levels of transcripts and proteins in aorta were determined by real-time PCR and Western blot analysis, respectively. Results: In comparison with the Group II, rice bran water extract administration resulted in a significant reduction in body weight, visceral fat tissue weights, blood glucose levels, and serum total-cholesterol and free fatty acid levels in Group III. Serum triglyceride levels tended to decrease in the Group III. Also, rice bran water extract administration obviously decreased malondialdehyde levels in both serum and aorta. Interestingly, rice bran water extract treatment demonstrated a significant up-regulation of eNOS expression and down-regulation of NF-κB p65 and CD36 expressions. Nonetheless, all groups showed normal histology of aorta. Conclusions: Rice bran water extract exhibited vasoprotective effects in the high-fat diet-induced obesity condition by modulating the expression of eNOS, NF-κB, and CD36 and metabolic parameters. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Asian Pacific Journal of Tropical Biomedicine 6 9 778 784 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Rice bran Metabolic syndrome Cardiovascular disease Endothelial nitric oxide synthase Nuclear factor-kappa B Cluster of differentiation 36 Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
spellingShingle |
Rice bran Metabolic syndrome Cardiovascular disease Endothelial nitric oxide synthase Nuclear factor-kappa B Cluster of differentiation 36 Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 Narongsuk Munkong Pintusorn Hansakul Bhornprom Yoysungnoen Ariyaphong Wongnoppavich Seewaboon Sireeratawong Noppamat Kaendee Nusiri Lerdvuthisopon Vasoprotective effects of rice bran water extract on rats fed with high-fat diet |
topic_facet |
Rice bran Metabolic syndrome Cardiovascular disease Endothelial nitric oxide synthase Nuclear factor-kappa B Cluster of differentiation 36 Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
description |
Objective: To elucidate the protective effects of rice bran water extract on the expression of endothelial nitric oxide synthase (eNOS), nuclear factor-kappa B (NF-κB), and a cluster of differentiation 36 (CD36) in the vasculature of high-fat diet-fed rats. Methods: Male Sprague-Dawley rats were divided into three groups. Group I served as control, Group II was treated with high-fat diet, and Group III was treated with high-fat diet and rice bran water extract at 2205 mg/kg/day. After four weeks, the metabolic parameters, malondialdehyde as a marker of oxidative stress, and histological features of the aorta were evaluated. The levels of transcripts and proteins in aorta were determined by real-time PCR and Western blot analysis, respectively. Results: In comparison with the Group II, rice bran water extract administration resulted in a significant reduction in body weight, visceral fat tissue weights, blood glucose levels, and serum total-cholesterol and free fatty acid levels in Group III. Serum triglyceride levels tended to decrease in the Group III. Also, rice bran water extract administration obviously decreased malondialdehyde levels in both serum and aorta. Interestingly, rice bran water extract treatment demonstrated a significant up-regulation of eNOS expression and down-regulation of NF-κB p65 and CD36 expressions. Nonetheless, all groups showed normal histology of aorta. Conclusions: Rice bran water extract exhibited vasoprotective effects in the high-fat diet-induced obesity condition by modulating the expression of eNOS, NF-κB, and CD36 and metabolic parameters. |
format |
Article in Journal/Newspaper |
author |
Narongsuk Munkong Pintusorn Hansakul Bhornprom Yoysungnoen Ariyaphong Wongnoppavich Seewaboon Sireeratawong Noppamat Kaendee Nusiri Lerdvuthisopon |
author_facet |
Narongsuk Munkong Pintusorn Hansakul Bhornprom Yoysungnoen Ariyaphong Wongnoppavich Seewaboon Sireeratawong Noppamat Kaendee Nusiri Lerdvuthisopon |
author_sort |
Narongsuk Munkong |
title |
Vasoprotective effects of rice bran water extract on rats fed with high-fat diet |
title_short |
Vasoprotective effects of rice bran water extract on rats fed with high-fat diet |
title_full |
Vasoprotective effects of rice bran water extract on rats fed with high-fat diet |
title_fullStr |
Vasoprotective effects of rice bran water extract on rats fed with high-fat diet |
title_full_unstemmed |
Vasoprotective effects of rice bran water extract on rats fed with high-fat diet |
title_sort |
vasoprotective effects of rice bran water extract on rats fed with high-fat diet |
publisher |
Wolters Kluwer Medknow Publications |
publishDate |
2016 |
url |
https://doi.org/10.1016/j.apjtb.2016.07.009 https://doaj.org/article/2d1a63a10c874145aaea8283f4fcc578 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Asian Pacific Journal of Tropical Biomedicine, Vol 6, Iss 9, Pp 778-784 (2016) |
op_relation |
http://www.sciencedirect.com/science/article/pii/S2221169115310285 https://doaj.org/toc/2221-1691 2221-1691 doi:10.1016/j.apjtb.2016.07.009 https://doaj.org/article/2d1a63a10c874145aaea8283f4fcc578 |
op_doi |
https://doi.org/10.1016/j.apjtb.2016.07.009 |
container_title |
Asian Pacific Journal of Tropical Biomedicine |
container_volume |
6 |
container_issue |
9 |
container_start_page |
778 |
op_container_end_page |
784 |
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