Vitamin D deficiency is a potential risk factor for lipid Amphotericin B nephrotoxicity.
Invasive fungal infections (IFI) is a worldwide serious health problem and Amphotericin B (AmB) has been considered the drug of choice for IFI treatment. Despite its efficacy, clinical use of AmB has been associated with renal toxicity. Some lines of evidence have shown that an extemporaneous lipid...
Published in: | PLOS Neglected Tropical Diseases |
---|---|
Main Authors: | , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Public Library of Science (PLoS)
2019
|
Subjects: | |
Online Access: | https://doi.org/10.1371/journal.pntd.0007567 https://doaj.org/article/2ce5d7f9b1974837945c64fc27108dbd |
id |
ftdoajarticles:oai:doaj.org/article:2ce5d7f9b1974837945c64fc27108dbd |
---|---|
record_format |
openpolar |
spelling |
ftdoajarticles:oai:doaj.org/article:2ce5d7f9b1974837945c64fc27108dbd 2024-02-11T10:01:44+01:00 Vitamin D deficiency is a potential risk factor for lipid Amphotericin B nephrotoxicity. Daniela Ferreira Ana Carolina de Bragança Rildo Aparecido Volpini Maria Heloisa Massola Shimizu Pedro Henrique França Gois Adriana Castello Costa Girardi Antonio Carlos Seguro Daniele Canale 2019-07-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0007567 https://doaj.org/article/2ce5d7f9b1974837945c64fc27108dbd EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0007567 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0007567 https://doaj.org/article/2ce5d7f9b1974837945c64fc27108dbd PLoS Neglected Tropical Diseases, Vol 13, Iss 7, p e0007567 (2019) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2019 ftdoajarticles https://doi.org/10.1371/journal.pntd.0007567 2024-01-21T01:35:50Z Invasive fungal infections (IFI) is a worldwide serious health problem and Amphotericin B (AmB) has been considered the drug of choice for IFI treatment. Despite its efficacy, clinical use of AmB has been associated with renal toxicity. Some lines of evidence have shown that an extemporaneous lipid emulsion preparation of AmB (AmB/LE) was able to attenuate nephrotoxicity, presenting similar benefits at a lower cost. Studies have been demonstrating that hypovitaminosis D may hasten the progression of kidney disease and reflect on a worse prognosis in cases of drug-induced nephrotoxicity. In view of the high worldwide incidence of hypovitaminosis D, the aim of this study was to investigate whether vitamin D deficiency may induce AmB/LE-related nephrotoxicity. Wistar rats were divided into four groups: control, received a standard diet for 34 days; AmB/LE, received a standard diet for 34 days and AmB/LE (5 mg/kg/day) intraperitoneally in the last 4 days; VDD, received a vitamin D-free diet for 34 days; and VDD+AmB/LE, received a vitamin D-free diet for 34 days and AmB/LE as described. At the end of the protocol, animals were euthanized and blood, urine and renal tissue samples were collected in order to evaluate AmB/LE effects on renal function and morphology. Association of AmB/LE and vitamin D deficiency led to diminished glomerular filtration rate and increased tubular injury, evidenced by reduced renal protein expression of NaPi-IIa and TRPM6 leading to hyperphosphaturia / hypermagnesuria. VDD+AmB/LE rats also presented alterations in the PTH-Klotho-FGF-23 signaling axis, urinary concentrating defect and hypertension, probably due to an inappropriate activation of the renin-angiotensin-aldosterone system. Hence, it is important to monitor vitamin D levels in AmB/LE treated patients, since vitamin D deficiency induces AmB/LE nephrotoxicity. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Napi ENVELOPE(-23.862,-23.862,65.428,65.428) PLOS Neglected Tropical Diseases 13 7 e0007567 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Daniela Ferreira Ana Carolina de Bragança Rildo Aparecido Volpini Maria Heloisa Massola Shimizu Pedro Henrique França Gois Adriana Castello Costa Girardi Antonio Carlos Seguro Daniele Canale Vitamin D deficiency is a potential risk factor for lipid Amphotericin B nephrotoxicity. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Invasive fungal infections (IFI) is a worldwide serious health problem and Amphotericin B (AmB) has been considered the drug of choice for IFI treatment. Despite its efficacy, clinical use of AmB has been associated with renal toxicity. Some lines of evidence have shown that an extemporaneous lipid emulsion preparation of AmB (AmB/LE) was able to attenuate nephrotoxicity, presenting similar benefits at a lower cost. Studies have been demonstrating that hypovitaminosis D may hasten the progression of kidney disease and reflect on a worse prognosis in cases of drug-induced nephrotoxicity. In view of the high worldwide incidence of hypovitaminosis D, the aim of this study was to investigate whether vitamin D deficiency may induce AmB/LE-related nephrotoxicity. Wistar rats were divided into four groups: control, received a standard diet for 34 days; AmB/LE, received a standard diet for 34 days and AmB/LE (5 mg/kg/day) intraperitoneally in the last 4 days; VDD, received a vitamin D-free diet for 34 days; and VDD+AmB/LE, received a vitamin D-free diet for 34 days and AmB/LE as described. At the end of the protocol, animals were euthanized and blood, urine and renal tissue samples were collected in order to evaluate AmB/LE effects on renal function and morphology. Association of AmB/LE and vitamin D deficiency led to diminished glomerular filtration rate and increased tubular injury, evidenced by reduced renal protein expression of NaPi-IIa and TRPM6 leading to hyperphosphaturia / hypermagnesuria. VDD+AmB/LE rats also presented alterations in the PTH-Klotho-FGF-23 signaling axis, urinary concentrating defect and hypertension, probably due to an inappropriate activation of the renin-angiotensin-aldosterone system. Hence, it is important to monitor vitamin D levels in AmB/LE treated patients, since vitamin D deficiency induces AmB/LE nephrotoxicity. |
format |
Article in Journal/Newspaper |
author |
Daniela Ferreira Ana Carolina de Bragança Rildo Aparecido Volpini Maria Heloisa Massola Shimizu Pedro Henrique França Gois Adriana Castello Costa Girardi Antonio Carlos Seguro Daniele Canale |
author_facet |
Daniela Ferreira Ana Carolina de Bragança Rildo Aparecido Volpini Maria Heloisa Massola Shimizu Pedro Henrique França Gois Adriana Castello Costa Girardi Antonio Carlos Seguro Daniele Canale |
author_sort |
Daniela Ferreira |
title |
Vitamin D deficiency is a potential risk factor for lipid Amphotericin B nephrotoxicity. |
title_short |
Vitamin D deficiency is a potential risk factor for lipid Amphotericin B nephrotoxicity. |
title_full |
Vitamin D deficiency is a potential risk factor for lipid Amphotericin B nephrotoxicity. |
title_fullStr |
Vitamin D deficiency is a potential risk factor for lipid Amphotericin B nephrotoxicity. |
title_full_unstemmed |
Vitamin D deficiency is a potential risk factor for lipid Amphotericin B nephrotoxicity. |
title_sort |
vitamin d deficiency is a potential risk factor for lipid amphotericin b nephrotoxicity. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2019 |
url |
https://doi.org/10.1371/journal.pntd.0007567 https://doaj.org/article/2ce5d7f9b1974837945c64fc27108dbd |
long_lat |
ENVELOPE(-23.862,-23.862,65.428,65.428) |
geographic |
Arctic Napi |
geographic_facet |
Arctic Napi |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 13, Iss 7, p e0007567 (2019) |
op_relation |
https://doi.org/10.1371/journal.pntd.0007567 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0007567 https://doaj.org/article/2ce5d7f9b1974837945c64fc27108dbd |
op_doi |
https://doi.org/10.1371/journal.pntd.0007567 |
container_title |
PLOS Neglected Tropical Diseases |
container_volume |
13 |
container_issue |
7 |
container_start_page |
e0007567 |
_version_ |
1790597532559081472 |