Morphological and genomic characterisation of the Schistosoma hybrid infecting humans in Europe reveals admixture between Schistosoma haematobium and Schistosoma bovis.
Schistosomes cause schistosomiasis, the world's second most important parasitic disease after malaria in terms of public health and social-economic impacts. A peculiar feature of these dioecious parasites is their ability to produce viable and fertile hybrid offspring. Originally only present i...
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ftdoajarticles:oai:doaj.org/article:2cd797f3028e49928c34ef1b4d9b265b 2023-05-15T15:11:13+02:00 Morphological and genomic characterisation of the Schistosoma hybrid infecting humans in Europe reveals admixture between Schistosoma haematobium and Schistosoma bovis. Julien Kincaid-Smith Alan Tracey Ronaldo de Carvalho Augusto Ingo Bulla Nancy Holroyd Anne Rognon Olivier Rey Cristian Chaparro Ana Oleaga Santiago Mas-Coma Jean-François Allienne Christoph Grunau Matthew Berriman Jérôme Boissier Eve Toulza 2021-12-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0010062 https://doaj.org/article/2cd797f3028e49928c34ef1b4d9b265b EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0010062 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0010062 https://doaj.org/article/2cd797f3028e49928c34ef1b4d9b265b PLoS Neglected Tropical Diseases, Vol 15, Iss 12, p e0010062 (2021) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2021 ftdoajarticles https://doi.org/10.1371/journal.pntd.0010062 2022-12-31T03:45:24Z Schistosomes cause schistosomiasis, the world's second most important parasitic disease after malaria in terms of public health and social-economic impacts. A peculiar feature of these dioecious parasites is their ability to produce viable and fertile hybrid offspring. Originally only present in the tropics, schistosomiasis is now also endemic in southern Europe. Based on the analysis of two genetic markers the European schistosomes had previously been identified as hybrids between the livestock- and the human-infective species Schistosoma bovis and Schistosoma haematobium, respectively. Here, using PacBio long-read sequencing technology we performed genome assembly improvement and annotation of S. bovis, one of the parental species for which no satisfactory genome assembly was available. We then describe the whole genome introgression levels of the hybrid schistosomes, their morphometric parameters (eggs and adult worms) and their compatibility with two European snail strains used as vectors (Bulinus truncatus and Planorbarius metidjensis). Schistosome-snail compatibility is a key parameter for the parasites life cycle progression, and thus the capability of the parasite to establish in a given area. Our results show that this Schistosoma hybrid is strongly introgressed genetically, composed of 77% S. haematobium and 23% S. bovis origin. This genomic admixture suggests an ancient hybridization event and subsequent backcrosses with the human-specific species, S. haematobium, before its introduction in Corsica. We also show that egg morphology (commonly used as a species diagnostic) does not allow for accurate hybrid identification while genetic tests do. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 15 12 e0010062 |
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Directory of Open Access Journals: DOAJ Articles |
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English |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Julien Kincaid-Smith Alan Tracey Ronaldo de Carvalho Augusto Ingo Bulla Nancy Holroyd Anne Rognon Olivier Rey Cristian Chaparro Ana Oleaga Santiago Mas-Coma Jean-François Allienne Christoph Grunau Matthew Berriman Jérôme Boissier Eve Toulza Morphological and genomic characterisation of the Schistosoma hybrid infecting humans in Europe reveals admixture between Schistosoma haematobium and Schistosoma bovis. |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Schistosomes cause schistosomiasis, the world's second most important parasitic disease after malaria in terms of public health and social-economic impacts. A peculiar feature of these dioecious parasites is their ability to produce viable and fertile hybrid offspring. Originally only present in the tropics, schistosomiasis is now also endemic in southern Europe. Based on the analysis of two genetic markers the European schistosomes had previously been identified as hybrids between the livestock- and the human-infective species Schistosoma bovis and Schistosoma haematobium, respectively. Here, using PacBio long-read sequencing technology we performed genome assembly improvement and annotation of S. bovis, one of the parental species for which no satisfactory genome assembly was available. We then describe the whole genome introgression levels of the hybrid schistosomes, their morphometric parameters (eggs and adult worms) and their compatibility with two European snail strains used as vectors (Bulinus truncatus and Planorbarius metidjensis). Schistosome-snail compatibility is a key parameter for the parasites life cycle progression, and thus the capability of the parasite to establish in a given area. Our results show that this Schistosoma hybrid is strongly introgressed genetically, composed of 77% S. haematobium and 23% S. bovis origin. This genomic admixture suggests an ancient hybridization event and subsequent backcrosses with the human-specific species, S. haematobium, before its introduction in Corsica. We also show that egg morphology (commonly used as a species diagnostic) does not allow for accurate hybrid identification while genetic tests do. |
format |
Article in Journal/Newspaper |
author |
Julien Kincaid-Smith Alan Tracey Ronaldo de Carvalho Augusto Ingo Bulla Nancy Holroyd Anne Rognon Olivier Rey Cristian Chaparro Ana Oleaga Santiago Mas-Coma Jean-François Allienne Christoph Grunau Matthew Berriman Jérôme Boissier Eve Toulza |
author_facet |
Julien Kincaid-Smith Alan Tracey Ronaldo de Carvalho Augusto Ingo Bulla Nancy Holroyd Anne Rognon Olivier Rey Cristian Chaparro Ana Oleaga Santiago Mas-Coma Jean-François Allienne Christoph Grunau Matthew Berriman Jérôme Boissier Eve Toulza |
author_sort |
Julien Kincaid-Smith |
title |
Morphological and genomic characterisation of the Schistosoma hybrid infecting humans in Europe reveals admixture between Schistosoma haematobium and Schistosoma bovis. |
title_short |
Morphological and genomic characterisation of the Schistosoma hybrid infecting humans in Europe reveals admixture between Schistosoma haematobium and Schistosoma bovis. |
title_full |
Morphological and genomic characterisation of the Schistosoma hybrid infecting humans in Europe reveals admixture between Schistosoma haematobium and Schistosoma bovis. |
title_fullStr |
Morphological and genomic characterisation of the Schistosoma hybrid infecting humans in Europe reveals admixture between Schistosoma haematobium and Schistosoma bovis. |
title_full_unstemmed |
Morphological and genomic characterisation of the Schistosoma hybrid infecting humans in Europe reveals admixture between Schistosoma haematobium and Schistosoma bovis. |
title_sort |
morphological and genomic characterisation of the schistosoma hybrid infecting humans in europe reveals admixture between schistosoma haematobium and schistosoma bovis. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2021 |
url |
https://doi.org/10.1371/journal.pntd.0010062 https://doaj.org/article/2cd797f3028e49928c34ef1b4d9b265b |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 15, Iss 12, p e0010062 (2021) |
op_relation |
https://doi.org/10.1371/journal.pntd.0010062 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0010062 https://doaj.org/article/2cd797f3028e49928c34ef1b4d9b265b |
op_doi |
https://doi.org/10.1371/journal.pntd.0010062 |
container_title |
PLOS Neglected Tropical Diseases |
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15 |
container_issue |
12 |
container_start_page |
e0010062 |
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1766342102184099840 |