The characteristics of current natural foci of hemorrhagic fever with renal syndrome in Shandong Province, China, 2012-2015.
Background Hemorrhagic fever with renal syndrome (HFRS), an infectious disease caused by hantaviruses, is endemic in China and remains a serious public health problem. Historically, Shandong Province has had the largest HFRS burden in China. However, we do not have a comprehensive and clear understa...
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ftdoajarticles:oai:doaj.org/article:2cbe5ee5ce9143408e42ca07500a8909 2023-05-15T15:09:52+02:00 The characteristics of current natural foci of hemorrhagic fever with renal syndrome in Shandong Province, China, 2012-2015. Zhaolei Zheng Peizhu Wang Zhiqiang Wang Dandan Zhang Xu Wang Shuqing Zuo Xiujun Li 2019-05-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0007148 https://doaj.org/article/2cbe5ee5ce9143408e42ca07500a8909 EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0007148 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0007148 https://doaj.org/article/2cbe5ee5ce9143408e42ca07500a8909 PLoS Neglected Tropical Diseases, Vol 13, Iss 5, p e0007148 (2019) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2019 ftdoajarticles https://doi.org/10.1371/journal.pntd.0007148 2022-12-31T05:07:34Z Background Hemorrhagic fever with renal syndrome (HFRS), an infectious disease caused by hantaviruses, is endemic in China and remains a serious public health problem. Historically, Shandong Province has had the largest HFRS burden in China. However, we do not have a comprehensive and clear understanding of the current epidemic foci of HFRS in Shandong Province. Methodology/principal findings The incidence and mortality rates were calculated, and a phylogenetic analysis was performed after laboratory testing of the virus in rodents. Spatial epidemiology analysis was applied to investigate the epidemic foci, including their sources. A total of 6,206 HFRS cases and 59 related deaths were reported in Shandong Province. The virus carriage rates of the rodents Rattus norvegicus, Apodemus agrarius and Mus musculus were 10.24%, 6.31% and 0.27%, respectively. The phylogenetic analysis indicated that two novel viruses obtained from R. norvegicus in Anqiu City and Qingzhou City were dissimilar to the other strains, but closely related to strains previously isolated in northeastern China. Three epidemic foci were defined, two of which were derived from the Jining and Linyi epidemic foci, respectively, while the other was the residue of the Jining epidemic focus. Conclusions/significance The southeastern and central Shandong Province are current key HFRS epidemic foci dominated by A. agrarius and R. norvegicus, respectively. Our study could help local departments to strengthen prevention and control measures in key areas to reduce the hazards of HFRS. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 13 5 e0007148 |
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Directory of Open Access Journals: DOAJ Articles |
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language |
English |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Zhaolei Zheng Peizhu Wang Zhiqiang Wang Dandan Zhang Xu Wang Shuqing Zuo Xiujun Li The characteristics of current natural foci of hemorrhagic fever with renal syndrome in Shandong Province, China, 2012-2015. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Background Hemorrhagic fever with renal syndrome (HFRS), an infectious disease caused by hantaviruses, is endemic in China and remains a serious public health problem. Historically, Shandong Province has had the largest HFRS burden in China. However, we do not have a comprehensive and clear understanding of the current epidemic foci of HFRS in Shandong Province. Methodology/principal findings The incidence and mortality rates were calculated, and a phylogenetic analysis was performed after laboratory testing of the virus in rodents. Spatial epidemiology analysis was applied to investigate the epidemic foci, including their sources. A total of 6,206 HFRS cases and 59 related deaths were reported in Shandong Province. The virus carriage rates of the rodents Rattus norvegicus, Apodemus agrarius and Mus musculus were 10.24%, 6.31% and 0.27%, respectively. The phylogenetic analysis indicated that two novel viruses obtained from R. norvegicus in Anqiu City and Qingzhou City were dissimilar to the other strains, but closely related to strains previously isolated in northeastern China. Three epidemic foci were defined, two of which were derived from the Jining and Linyi epidemic foci, respectively, while the other was the residue of the Jining epidemic focus. Conclusions/significance The southeastern and central Shandong Province are current key HFRS epidemic foci dominated by A. agrarius and R. norvegicus, respectively. Our study could help local departments to strengthen prevention and control measures in key areas to reduce the hazards of HFRS. |
format |
Article in Journal/Newspaper |
author |
Zhaolei Zheng Peizhu Wang Zhiqiang Wang Dandan Zhang Xu Wang Shuqing Zuo Xiujun Li |
author_facet |
Zhaolei Zheng Peizhu Wang Zhiqiang Wang Dandan Zhang Xu Wang Shuqing Zuo Xiujun Li |
author_sort |
Zhaolei Zheng |
title |
The characteristics of current natural foci of hemorrhagic fever with renal syndrome in Shandong Province, China, 2012-2015. |
title_short |
The characteristics of current natural foci of hemorrhagic fever with renal syndrome in Shandong Province, China, 2012-2015. |
title_full |
The characteristics of current natural foci of hemorrhagic fever with renal syndrome in Shandong Province, China, 2012-2015. |
title_fullStr |
The characteristics of current natural foci of hemorrhagic fever with renal syndrome in Shandong Province, China, 2012-2015. |
title_full_unstemmed |
The characteristics of current natural foci of hemorrhagic fever with renal syndrome in Shandong Province, China, 2012-2015. |
title_sort |
characteristics of current natural foci of hemorrhagic fever with renal syndrome in shandong province, china, 2012-2015. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2019 |
url |
https://doi.org/10.1371/journal.pntd.0007148 https://doaj.org/article/2cbe5ee5ce9143408e42ca07500a8909 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 13, Iss 5, p e0007148 (2019) |
op_relation |
https://doi.org/10.1371/journal.pntd.0007148 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0007148 https://doaj.org/article/2cbe5ee5ce9143408e42ca07500a8909 |
op_doi |
https://doi.org/10.1371/journal.pntd.0007148 |
container_title |
PLOS Neglected Tropical Diseases |
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13 |
container_issue |
5 |
container_start_page |
e0007148 |
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