In vitro and in vivo growth inhibitory activities of cryptolepine hydrate against several Babesia species and Theileria equi.

• Published in: PLOS Neglected Tropical Diseases
• Main Authors: Gaber El-Saber Batiha, Amany Magdy Beshbishy, Luay M Alkazmi, Eman H Nadwa, Eman K Rashwan, Naoaki Yokoyama, Ikuo Igarashi
• Format: Article in Journal/Newspaper
• Language: English
• Published: Public Library of Science (PLoS) 2020
• Subjects: Arctic medicine. Tropical medicine; RC955-962; Public aspects of medicine; RA1-1270; Arctic; Darby
• Online Access: https://doi.org/10.1371/journal.pntd.0008489; https://doaj.org/article/2c86213af4ad45428b0496edce808917

Piroplasmosis treatment has been based on the use of imidocarb dipropionate or diminazene aceturate (DA), however, their toxic effects. Therefore, the discovery of new drug molecules and targets is urgently needed. Cryptolepine (CRY) is a pharmacologically active plant alkaloid; it has significant p...