Elucidating transmission dynamics and host-parasite-vector relationships for rodent-borne Bartonella spp. in Madagascar
Bartonella spp. are erythrocytic bacteria transmitted via arthropod vectors, which infect a broad range of vertebrate hosts, including humans. We investigated transmission dynamics and host-parasite-vector relationships for potentially zoonotic Bartonella spp. in invasive Rattus rattus hosts and ass...
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ftdoajarticles:oai:doaj.org/article:2c1ed60b00db466cb57b80dd3040dcc2 2023-05-15T18:05:06+02:00 Elucidating transmission dynamics and host-parasite-vector relationships for rodent-borne Bartonella spp. in Madagascar Cara E. Brook Ying Bai Emily O. Yu Hafaliana C. Ranaivoson Haewon Shin Andrew P. Dobson C. Jessica E. Metcalf Michael Y. Kosoy Katharina Dittmar 2017-09-01T00:00:00Z https://doi.org/10.1016/j.epidem.2017.03.004 https://doaj.org/article/2c1ed60b00db466cb57b80dd3040dcc2 EN eng Elsevier http://www.sciencedirect.com/science/article/pii/S1755436517300634 https://doaj.org/toc/1755-4365 https://doaj.org/toc/1878-0067 1755-4365 1878-0067 doi:10.1016/j.epidem.2017.03.004 https://doaj.org/article/2c1ed60b00db466cb57b80dd3040dcc2 Epidemics, Vol 20, Iss C, Pp 56-66 (2017) Bartonella spp Rattus rattus Synopsyllus fonquerniei Madagascar Force of infection Infectious and parasitic diseases RC109-216 article 2017 ftdoajarticles https://doi.org/10.1016/j.epidem.2017.03.004 2022-12-31T08:49:23Z Bartonella spp. are erythrocytic bacteria transmitted via arthropod vectors, which infect a broad range of vertebrate hosts, including humans. We investigated transmission dynamics and host-parasite-vector relationships for potentially zoonotic Bartonella spp. in invasive Rattus rattus hosts and associated arthropod ectoparasites in Madagascar. We identified five distinct species of Bartonella (B. elizabethae 1, B. elizabethae 2, B. phoceensis 1, B. rattimassiliensis 1, and B. tribocorum 1) infecting R. rattus rodents and their ectoparasites. We fit standard epidemiological models to species-specific age-prevalence data for the four Bartonella spp. with sufficient data, thus quantifying age-structured force of infection. Known zoonotic agents, B. elizabethae 1 and 2, were best described by models exhibiting high forces of infection in early age class individuals and allowing for recovery from infection, while B. phoceensis 1 and B. rattimassiliensis 1 were best fit by models of lifelong infection without recovery and substantially lower forces of infection. Nested sequences of B. elizabethae 1 and 2 were recovered from rodent hosts and their Synopsyllus fonquerniei and Xenopsylla cheopsis fleas, with a particularly high prevalence in the outdoor-dwelling, highland-endemic S. fonquerniei. These findings expand on force of infection analyses to elucidate the ecological niche of the zoonotic Bartonella elizabethae complex in Madagascar, hinting at a potential vector role for S. fonquerniei. Our analyses underscore the uniqueness of such ecologies for Bartonella species, which pose a variable range of potential zoonotic threats. Article in Journal/Newspaper Rattus rattus Directory of Open Access Journals: DOAJ Articles Epidemics 20 56 66 |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Bartonella spp Rattus rattus Synopsyllus fonquerniei Madagascar Force of infection Infectious and parasitic diseases RC109-216 |
spellingShingle |
Bartonella spp Rattus rattus Synopsyllus fonquerniei Madagascar Force of infection Infectious and parasitic diseases RC109-216 Cara E. Brook Ying Bai Emily O. Yu Hafaliana C. Ranaivoson Haewon Shin Andrew P. Dobson C. Jessica E. Metcalf Michael Y. Kosoy Katharina Dittmar Elucidating transmission dynamics and host-parasite-vector relationships for rodent-borne Bartonella spp. in Madagascar |
topic_facet |
Bartonella spp Rattus rattus Synopsyllus fonquerniei Madagascar Force of infection Infectious and parasitic diseases RC109-216 |
description |
Bartonella spp. are erythrocytic bacteria transmitted via arthropod vectors, which infect a broad range of vertebrate hosts, including humans. We investigated transmission dynamics and host-parasite-vector relationships for potentially zoonotic Bartonella spp. in invasive Rattus rattus hosts and associated arthropod ectoparasites in Madagascar. We identified five distinct species of Bartonella (B. elizabethae 1, B. elizabethae 2, B. phoceensis 1, B. rattimassiliensis 1, and B. tribocorum 1) infecting R. rattus rodents and their ectoparasites. We fit standard epidemiological models to species-specific age-prevalence data for the four Bartonella spp. with sufficient data, thus quantifying age-structured force of infection. Known zoonotic agents, B. elizabethae 1 and 2, were best described by models exhibiting high forces of infection in early age class individuals and allowing for recovery from infection, while B. phoceensis 1 and B. rattimassiliensis 1 were best fit by models of lifelong infection without recovery and substantially lower forces of infection. Nested sequences of B. elizabethae 1 and 2 were recovered from rodent hosts and their Synopsyllus fonquerniei and Xenopsylla cheopsis fleas, with a particularly high prevalence in the outdoor-dwelling, highland-endemic S. fonquerniei. These findings expand on force of infection analyses to elucidate the ecological niche of the zoonotic Bartonella elizabethae complex in Madagascar, hinting at a potential vector role for S. fonquerniei. Our analyses underscore the uniqueness of such ecologies for Bartonella species, which pose a variable range of potential zoonotic threats. |
format |
Article in Journal/Newspaper |
author |
Cara E. Brook Ying Bai Emily O. Yu Hafaliana C. Ranaivoson Haewon Shin Andrew P. Dobson C. Jessica E. Metcalf Michael Y. Kosoy Katharina Dittmar |
author_facet |
Cara E. Brook Ying Bai Emily O. Yu Hafaliana C. Ranaivoson Haewon Shin Andrew P. Dobson C. Jessica E. Metcalf Michael Y. Kosoy Katharina Dittmar |
author_sort |
Cara E. Brook |
title |
Elucidating transmission dynamics and host-parasite-vector relationships for rodent-borne Bartonella spp. in Madagascar |
title_short |
Elucidating transmission dynamics and host-parasite-vector relationships for rodent-borne Bartonella spp. in Madagascar |
title_full |
Elucidating transmission dynamics and host-parasite-vector relationships for rodent-borne Bartonella spp. in Madagascar |
title_fullStr |
Elucidating transmission dynamics and host-parasite-vector relationships for rodent-borne Bartonella spp. in Madagascar |
title_full_unstemmed |
Elucidating transmission dynamics and host-parasite-vector relationships for rodent-borne Bartonella spp. in Madagascar |
title_sort |
elucidating transmission dynamics and host-parasite-vector relationships for rodent-borne bartonella spp. in madagascar |
publisher |
Elsevier |
publishDate |
2017 |
url |
https://doi.org/10.1016/j.epidem.2017.03.004 https://doaj.org/article/2c1ed60b00db466cb57b80dd3040dcc2 |
genre |
Rattus rattus |
genre_facet |
Rattus rattus |
op_source |
Epidemics, Vol 20, Iss C, Pp 56-66 (2017) |
op_relation |
http://www.sciencedirect.com/science/article/pii/S1755436517300634 https://doaj.org/toc/1755-4365 https://doaj.org/toc/1878-0067 1755-4365 1878-0067 doi:10.1016/j.epidem.2017.03.004 https://doaj.org/article/2c1ed60b00db466cb57b80dd3040dcc2 |
op_doi |
https://doi.org/10.1016/j.epidem.2017.03.004 |
container_title |
Epidemics |
container_volume |
20 |
container_start_page |
56 |
op_container_end_page |
66 |
_version_ |
1766176527092809728 |