Human polyclonal anti-hepatitis B surface antigen immunoglobulin reduces the frequency of acute rejection after liver transplantation for chronic hepatitis B
BACKGROUND: Use of polyclonal anti-hepatitis B surface antigen immunoglobulin (HBIg) has been shown to reduce hepatitis B virus (HBV) recurrence after liver transplantation (LT) and to decrease the frequency of acute cellular rejection (ACR). However, the protective role of HBIg against ACR remains...
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Universidade de São Paulo (USP)
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ftdoajarticles:oai:doaj.org/article:2c1877ab0381471fb6a2036a7e88223b 2024-09-09T19:26:32+00:00 Human polyclonal anti-hepatitis B surface antigen immunoglobulin reduces the frequency of acute rejection after liver transplantation for chronic hepatitis B Claudia Alves COUTO Paulo Lisboa BITTENCOURT Alberto Queiroz FARIAS Margareth Pauli LALLEE Eduardo Luiz Rachid CANÇADO Paulo Celso Bosco MASSAROLLO Sérgio MIES 2001-12-01T00:00:00Z https://doaj.org/article/2c1877ab0381471fb6a2036a7e88223b EN eng Universidade de São Paulo (USP) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46652001000600007&tlng=en https://doaj.org/toc/1678-9946 1678-9946 https://doaj.org/article/2c1877ab0381471fb6a2036a7e88223b Revista do Instituto de Medicina Tropical de São Paulo, Vol 43, Iss 6, Pp 335-337 (2001) HBIg Acute hepatic rejection Liver transplantation Chronic hepatitis B Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2001 ftdoajarticles 2024-08-05T17:49:30Z BACKGROUND: Use of polyclonal anti-hepatitis B surface antigen immunoglobulin (HBIg) has been shown to reduce hepatitis B virus (HBV) recurrence after liver transplantation (LT) and to decrease the frequency of acute cellular rejection (ACR). However, the protective role of HBIg against ACR remains controversial, since HBV infection has been also associated with a lower incidence of ACR. AIM: To assess the relationship between HBIg immunoprophylaxis and the incidence of rejection after LT. METHODS: 260 patients (158 males, 43 ± 14 years old) submitted to LT were retrospectively evaluated and divided into three groups, according to the presence of HBsAg and the use of HBIg. Group I was comprised of HBsAg-positive patients (n = 12) that received HBIg for more than 6 months. Group II was comprised of HBsAg-positive patients that historically have not received HBIg or have been treated irregularly for less than 3 months (n = 10). Group III was composed of 238 HBsAg-negative subjects that have not received HBIg. RESULTS: HBIg-treated patients (group I) had significantly less ACR episodes, when compared to group II and III. No differences between groups II and III were observed. CONCLUSIONS: Long-term HBIg administration contributes independently to reduce the number of ACR episodes after LT. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
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English |
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HBIg Acute hepatic rejection Liver transplantation Chronic hepatitis B Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
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HBIg Acute hepatic rejection Liver transplantation Chronic hepatitis B Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Claudia Alves COUTO Paulo Lisboa BITTENCOURT Alberto Queiroz FARIAS Margareth Pauli LALLEE Eduardo Luiz Rachid CANÇADO Paulo Celso Bosco MASSAROLLO Sérgio MIES Human polyclonal anti-hepatitis B surface antigen immunoglobulin reduces the frequency of acute rejection after liver transplantation for chronic hepatitis B |
topic_facet |
HBIg Acute hepatic rejection Liver transplantation Chronic hepatitis B Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
BACKGROUND: Use of polyclonal anti-hepatitis B surface antigen immunoglobulin (HBIg) has been shown to reduce hepatitis B virus (HBV) recurrence after liver transplantation (LT) and to decrease the frequency of acute cellular rejection (ACR). However, the protective role of HBIg against ACR remains controversial, since HBV infection has been also associated with a lower incidence of ACR. AIM: To assess the relationship between HBIg immunoprophylaxis and the incidence of rejection after LT. METHODS: 260 patients (158 males, 43 ± 14 years old) submitted to LT were retrospectively evaluated and divided into three groups, according to the presence of HBsAg and the use of HBIg. Group I was comprised of HBsAg-positive patients (n = 12) that received HBIg for more than 6 months. Group II was comprised of HBsAg-positive patients that historically have not received HBIg or have been treated irregularly for less than 3 months (n = 10). Group III was composed of 238 HBsAg-negative subjects that have not received HBIg. RESULTS: HBIg-treated patients (group I) had significantly less ACR episodes, when compared to group II and III. No differences between groups II and III were observed. CONCLUSIONS: Long-term HBIg administration contributes independently to reduce the number of ACR episodes after LT. |
format |
Article in Journal/Newspaper |
author |
Claudia Alves COUTO Paulo Lisboa BITTENCOURT Alberto Queiroz FARIAS Margareth Pauli LALLEE Eduardo Luiz Rachid CANÇADO Paulo Celso Bosco MASSAROLLO Sérgio MIES |
author_facet |
Claudia Alves COUTO Paulo Lisboa BITTENCOURT Alberto Queiroz FARIAS Margareth Pauli LALLEE Eduardo Luiz Rachid CANÇADO Paulo Celso Bosco MASSAROLLO Sérgio MIES |
author_sort |
Claudia Alves COUTO |
title |
Human polyclonal anti-hepatitis B surface antigen immunoglobulin reduces the frequency of acute rejection after liver transplantation for chronic hepatitis B |
title_short |
Human polyclonal anti-hepatitis B surface antigen immunoglobulin reduces the frequency of acute rejection after liver transplantation for chronic hepatitis B |
title_full |
Human polyclonal anti-hepatitis B surface antigen immunoglobulin reduces the frequency of acute rejection after liver transplantation for chronic hepatitis B |
title_fullStr |
Human polyclonal anti-hepatitis B surface antigen immunoglobulin reduces the frequency of acute rejection after liver transplantation for chronic hepatitis B |
title_full_unstemmed |
Human polyclonal anti-hepatitis B surface antigen immunoglobulin reduces the frequency of acute rejection after liver transplantation for chronic hepatitis B |
title_sort |
human polyclonal anti-hepatitis b surface antigen immunoglobulin reduces the frequency of acute rejection after liver transplantation for chronic hepatitis b |
publisher |
Universidade de São Paulo (USP) |
publishDate |
2001 |
url |
https://doaj.org/article/2c1877ab0381471fb6a2036a7e88223b |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista do Instituto de Medicina Tropical de São Paulo, Vol 43, Iss 6, Pp 335-337 (2001) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46652001000600007&tlng=en https://doaj.org/toc/1678-9946 1678-9946 https://doaj.org/article/2c1877ab0381471fb6a2036a7e88223b |
_version_ |
1809896134050578432 |