Detection of Trypanosoma cruzi antibodies in multitransfused patients in Colombia
Introduction: Chagas disease is a public health problem in Latin America. Even though vector-borne infection is the most important transmission mode for this disease, other modes such as transfusions require evaluation. Objective: To describe the prevalence of T. cruzi infection in multitransfused p...
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ftdoajarticles:oai:doaj.org/article:2c08c20a4dd04bb2a03e160b19c505fa 2023-05-15T15:11:19+02:00 Detection of Trypanosoma cruzi antibodies in multitransfused patients in Colombia Mauricio Beltrán Andrea Herrera Astrid Carolina Flórez Maritza Berrio María Isabel Bermúdez 2017-09-01T00:00:00Z https://doi.org/10.7705/biomedica.v37i3.3177 https://doaj.org/article/2c08c20a4dd04bb2a03e160b19c505fa EN ES eng spa Instituto Nacional de Salud https://www.revistabiomedica.org/index.php/biomedica/article/view/3177 https://doaj.org/toc/0120-4157 0120-4157 doi:10.7705/biomedica.v37i3.3177 https://doaj.org/article/2c08c20a4dd04bb2a03e160b19c505fa Biomédica: revista del Instituto Nacional de Salud, Vol 37, Iss 3, Pp 361-367 (2017) Trypanosoma cruzi blood transfusion prevalence risk factors antibodies hemophilia A Medicine R Arctic medicine. Tropical medicine RC955-962 article 2017 ftdoajarticles https://doi.org/10.7705/biomedica.v37i3.3177 2022-12-30T23:57:39Z Introduction: Chagas disease is a public health problem in Latin America. Even though vector-borne infection is the most important transmission mode for this disease, other modes such as transfusions require evaluation. Objective: To describe the prevalence of T. cruzi infection in multitransfused patients. Materials and methods: We detected IgG antibodies against T. cruzi by two immunoassays in samples from multitransfused patients in four hospitals located in Bogotá and Medellín, Colombia. We analyzed the association with known risk factors, and we calculated the odds ratios (OR) with 95% confidence intervals using Stata 11™ statistical software. Results: In total, 479 samples were tested. Overall, T. cruzi antibody prevalence was 1.88% (nine patients). Five were onco-hematological patients, two were hemodialyzed, one had thalassemia, and one had suffered acute blood loss. We found no hemophilia patients. There was no association between known risk factors for transfusion-transmitted infection (such as the number of transfusion events, number of blood units and type of blood component) and the presence of anti-T. cruzi antibodies in this study. Only the hepatitis C virus infection showed a positive association with the presence of anti-T. cruzi antibodies (OR=5.68, 95% CI: 1.36-23.63). Conclusions: The results of this study showed a low frequency of T. cruzi infection in multitransfused patients, suggesting that the risk of transfusion infection in Colombia is low. Known risk factors for transfusion-related infection were not associated with the presence of anti-T. cruzi antibodies. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Biomédica 37 3 361 |
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Trypanosoma cruzi blood transfusion prevalence risk factors antibodies hemophilia A Medicine R Arctic medicine. Tropical medicine RC955-962 |
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Trypanosoma cruzi blood transfusion prevalence risk factors antibodies hemophilia A Medicine R Arctic medicine. Tropical medicine RC955-962 Mauricio Beltrán Andrea Herrera Astrid Carolina Flórez Maritza Berrio María Isabel Bermúdez Detection of Trypanosoma cruzi antibodies in multitransfused patients in Colombia |
topic_facet |
Trypanosoma cruzi blood transfusion prevalence risk factors antibodies hemophilia A Medicine R Arctic medicine. Tropical medicine RC955-962 |
description |
Introduction: Chagas disease is a public health problem in Latin America. Even though vector-borne infection is the most important transmission mode for this disease, other modes such as transfusions require evaluation. Objective: To describe the prevalence of T. cruzi infection in multitransfused patients. Materials and methods: We detected IgG antibodies against T. cruzi by two immunoassays in samples from multitransfused patients in four hospitals located in Bogotá and Medellín, Colombia. We analyzed the association with known risk factors, and we calculated the odds ratios (OR) with 95% confidence intervals using Stata 11™ statistical software. Results: In total, 479 samples were tested. Overall, T. cruzi antibody prevalence was 1.88% (nine patients). Five were onco-hematological patients, two were hemodialyzed, one had thalassemia, and one had suffered acute blood loss. We found no hemophilia patients. There was no association between known risk factors for transfusion-transmitted infection (such as the number of transfusion events, number of blood units and type of blood component) and the presence of anti-T. cruzi antibodies in this study. Only the hepatitis C virus infection showed a positive association with the presence of anti-T. cruzi antibodies (OR=5.68, 95% CI: 1.36-23.63). Conclusions: The results of this study showed a low frequency of T. cruzi infection in multitransfused patients, suggesting that the risk of transfusion infection in Colombia is low. Known risk factors for transfusion-related infection were not associated with the presence of anti-T. cruzi antibodies. |
format |
Article in Journal/Newspaper |
author |
Mauricio Beltrán Andrea Herrera Astrid Carolina Flórez Maritza Berrio María Isabel Bermúdez |
author_facet |
Mauricio Beltrán Andrea Herrera Astrid Carolina Flórez Maritza Berrio María Isabel Bermúdez |
author_sort |
Mauricio Beltrán |
title |
Detection of Trypanosoma cruzi antibodies in multitransfused patients in Colombia |
title_short |
Detection of Trypanosoma cruzi antibodies in multitransfused patients in Colombia |
title_full |
Detection of Trypanosoma cruzi antibodies in multitransfused patients in Colombia |
title_fullStr |
Detection of Trypanosoma cruzi antibodies in multitransfused patients in Colombia |
title_full_unstemmed |
Detection of Trypanosoma cruzi antibodies in multitransfused patients in Colombia |
title_sort |
detection of trypanosoma cruzi antibodies in multitransfused patients in colombia |
publisher |
Instituto Nacional de Salud |
publishDate |
2017 |
url |
https://doi.org/10.7705/biomedica.v37i3.3177 https://doaj.org/article/2c08c20a4dd04bb2a03e160b19c505fa |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Biomédica: revista del Instituto Nacional de Salud, Vol 37, Iss 3, Pp 361-367 (2017) |
op_relation |
https://www.revistabiomedica.org/index.php/biomedica/article/view/3177 https://doaj.org/toc/0120-4157 0120-4157 doi:10.7705/biomedica.v37i3.3177 https://doaj.org/article/2c08c20a4dd04bb2a03e160b19c505fa |
op_doi |
https://doi.org/10.7705/biomedica.v37i3.3177 |
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Biomédica |
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37 |
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361 |
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