Risk Factors for Death from Visceral Leishmaniasis in an Urban Area of Brazil.
BACKGROUND:Over the last three decades, the epidemiological profile of visceral leishmaniasis (VL) has changed with epidemics occurring in large urban centers of Brazil, an increase in HIV/AIDS co-infection, and a significant increase in mortality. The objective of this study was to identify the ris...
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ftdoajarticles:oai:doaj.org/article:2c07a0b86b8a4a3cbc46091a94ca302a 2023-05-15T15:06:22+02:00 Risk Factors for Death from Visceral Leishmaniasis in an Urban Area of Brazil. Angelita F Druzian Albert S de Souza Diogo N de Campos Julio Croda Minoru G Higa Maria Elizabeth C Dorval Mauricio A Pompilio Polliana A de Oliveira Anamaria M M Paniago 2015-01-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0003982 https://doaj.org/article/2c07a0b86b8a4a3cbc46091a94ca302a EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC4537269?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0003982 https://doaj.org/article/2c07a0b86b8a4a3cbc46091a94ca302a PLoS Neglected Tropical Diseases, Vol 9, Iss 8, p e0003982 (2015) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2015 ftdoajarticles https://doi.org/10.1371/journal.pntd.0003982 2022-12-31T11:55:00Z BACKGROUND:Over the last three decades, the epidemiological profile of visceral leishmaniasis (VL) has changed with epidemics occurring in large urban centers of Brazil, an increase in HIV/AIDS co-infection, and a significant increase in mortality. The objective of this study was to identify the risk factors associated with death among adult patients with VL from an urban endemic area of Brazil. METHODOLOGY:A prospective cohort study included 134 adult patients with VL admitted to the University Hospital of the Federal University of Mato Grosso do Sul between August 2011 and August 2013. PRINCIPAL FINDINGS:Patients ranged from 18 to 93 years old, with a mean age of 43.6 (±15.7%). Of these patients, 36.6% were co-infected with HIV/AIDS, and the mortality rate was 21.6%. In a multivariate analysis, the risk factors associated with death were secondary bacterial infection (42.86, 5.05-363.85), relapse (12.17, 2.06-71.99), edema (7.74, 1.33-45.05) and HIV/AIDS co-infection (7.33, 1.22-43.98). CONCLUSIONS/SIGNIFICANCE:VL has a high mortality rate in adults from endemic urban areas, especially when coinciding with high rates of HIV/AIDS co-infection. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 9 8 e0003982 |
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Directory of Open Access Journals: DOAJ Articles |
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English |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Angelita F Druzian Albert S de Souza Diogo N de Campos Julio Croda Minoru G Higa Maria Elizabeth C Dorval Mauricio A Pompilio Polliana A de Oliveira Anamaria M M Paniago Risk Factors for Death from Visceral Leishmaniasis in an Urban Area of Brazil. |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
BACKGROUND:Over the last three decades, the epidemiological profile of visceral leishmaniasis (VL) has changed with epidemics occurring in large urban centers of Brazil, an increase in HIV/AIDS co-infection, and a significant increase in mortality. The objective of this study was to identify the risk factors associated with death among adult patients with VL from an urban endemic area of Brazil. METHODOLOGY:A prospective cohort study included 134 adult patients with VL admitted to the University Hospital of the Federal University of Mato Grosso do Sul between August 2011 and August 2013. PRINCIPAL FINDINGS:Patients ranged from 18 to 93 years old, with a mean age of 43.6 (±15.7%). Of these patients, 36.6% were co-infected with HIV/AIDS, and the mortality rate was 21.6%. In a multivariate analysis, the risk factors associated with death were secondary bacterial infection (42.86, 5.05-363.85), relapse (12.17, 2.06-71.99), edema (7.74, 1.33-45.05) and HIV/AIDS co-infection (7.33, 1.22-43.98). CONCLUSIONS/SIGNIFICANCE:VL has a high mortality rate in adults from endemic urban areas, especially when coinciding with high rates of HIV/AIDS co-infection. |
format |
Article in Journal/Newspaper |
author |
Angelita F Druzian Albert S de Souza Diogo N de Campos Julio Croda Minoru G Higa Maria Elizabeth C Dorval Mauricio A Pompilio Polliana A de Oliveira Anamaria M M Paniago |
author_facet |
Angelita F Druzian Albert S de Souza Diogo N de Campos Julio Croda Minoru G Higa Maria Elizabeth C Dorval Mauricio A Pompilio Polliana A de Oliveira Anamaria M M Paniago |
author_sort |
Angelita F Druzian |
title |
Risk Factors for Death from Visceral Leishmaniasis in an Urban Area of Brazil. |
title_short |
Risk Factors for Death from Visceral Leishmaniasis in an Urban Area of Brazil. |
title_full |
Risk Factors for Death from Visceral Leishmaniasis in an Urban Area of Brazil. |
title_fullStr |
Risk Factors for Death from Visceral Leishmaniasis in an Urban Area of Brazil. |
title_full_unstemmed |
Risk Factors for Death from Visceral Leishmaniasis in an Urban Area of Brazil. |
title_sort |
risk factors for death from visceral leishmaniasis in an urban area of brazil. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2015 |
url |
https://doi.org/10.1371/journal.pntd.0003982 https://doaj.org/article/2c07a0b86b8a4a3cbc46091a94ca302a |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 9, Iss 8, p e0003982 (2015) |
op_relation |
http://europepmc.org/articles/PMC4537269?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0003982 https://doaj.org/article/2c07a0b86b8a4a3cbc46091a94ca302a |
op_doi |
https://doi.org/10.1371/journal.pntd.0003982 |
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PLOS Neglected Tropical Diseases |
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9 |
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8 |
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e0003982 |
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