Synergic kinetic and physiological control to improve the efficiency of Komagataella phaffii recombinant protein production bioprocesses

• Published in: Microbial Biotechnology
• Main Authors: Albert Sales‐Vallverdú, Arnau Gasset, Guillermo Requena‐Moreno, Francisco Valero, José Luis Montesinos‐Seguí, Xavier Garcia‐Ortega
• Format: Article in Journal/Newspaper
• Language: English
• Published: Wiley 2024
• Subjects: Biotechnology; TP248.13-248.65; Rugosa; The Bench; Antarc*; Antarctica
• Online Access: https://doi.org/10.1111/1751-7915.14411; https://doaj.org/article/2bceed3ff2ee4e14b951d7274e2373b6

Abstract The yeast Komagataella phaffii (Pichia pastoris) is currently considered a versatile and highly efficient host for recombinant protein production (RPP). Interestingly, the regulated application of specific stress factors as part of bioprocess engineering strategies has proven potential for...