Aptamer based, non-PCR, non-serological detection of Chagas disease biomarkers in Trypanosoma cruzi infected mice.

• Published in: PLoS Neglected Tropical Diseases
• Main Authors: Rana Nagarkatti, Fernanda Fortes de Araujo, Charu Gupta, Alain Debrabant
• Format: Article in Journal/Newspaper
• Language: English
• Published: Public Library of Science (PLoS) 2014
• Subjects: Arctic medicine. Tropical medicine; RC955-962; Public aspects of medicine; RA1-1270; Arctic; Ela
• Online Access: https://doi.org/10.1371/journal.pntd.0002650; https://doaj.org/article/2bbd85133e5e46dd86c588f08a3270ca

Chagas disease affects about 5 million people across the world. The etiological agent, the intracellular parasite Trypanosoma cruzi (T. cruzi), can be diagnosed using microscopy, serology or PCR based assays. However, each of these methods has their limitations regarding sensitivity and specificity,...