Prevalence and relevant factors of positive RF in brucellosis patients with arthralgia.
Background Brucellosis is a critical zoonotic disease in the world, it is the non-specific arthralgia that make brucellosis patients easily misdiagnosed as rheumatoid arthritis (RA) in endemic regions. Elevated rheumatoid factor (RF) is an essential indicator of RA, and the RF in brucellosis patient...
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ftdoajarticles:oai:doaj.org/article:2bae56b5b79d4ef6841fd7d7651d72bb 2023-05-15T15:15:44+02:00 Prevalence and relevant factors of positive RF in brucellosis patients with arthralgia. Siwen Zhang Jing Hu Shuqi An Mujinyan Li Fande Li Peng Zhang Xiangyi Zhang Huixin Yang Taijun Wang Jingjing Luo Fangfang Hu Jiashuo Liu Qing Zhen 2021-09-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0009749 https://doaj.org/article/2bae56b5b79d4ef6841fd7d7651d72bb EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0009749 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0009749 https://doaj.org/article/2bae56b5b79d4ef6841fd7d7651d72bb PLoS Neglected Tropical Diseases, Vol 15, Iss 9, p e0009749 (2021) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2021 ftdoajarticles https://doi.org/10.1371/journal.pntd.0009749 2022-12-31T15:16:59Z Background Brucellosis is a critical zoonotic disease in the world, it is the non-specific arthralgia that make brucellosis patients easily misdiagnosed as rheumatoid arthritis (RA) in endemic regions. Elevated rheumatoid factor (RF) is an essential indicator of RA, and the RF in brucellosis patients is significantly higher than healthy people. Therefore, this study further explored the distribution of RF and the relevant factors of the RF positivity in brucellosis patients with arthralgia, in order to strengthen the recognition of physicians for brucellosis patients with RF positivity, especially in brucellosis-endemic areas, so as to avoid misdiagnosis and untimely treatment that may lead to malignant outcomes. Methodology and principal findings The medical records of all 572 brucellosis inpatients were collected in the Sixth People's Hospital of Shenyang, China from 2015 to 2016. After excluding 106 patients without arthralgia, 5 patients who unwilling to perform RF testing and 16 patients with diseases that may affect RF, 445 brucellosis inpatients with arthralgia were involved in this retrospective cross-sectional study. 143 (32.1%) patients with RF >10 IU/ml were classified into the RF positive group, with an average level of 16.5[12.2, 34.7] IU/ml, of which 45 (10.1%) patients were high-positive with RF >30 IU/ml. Multivariate logistic regression model was used to further analyze the relevant factors of the RF positivity and found that age, wrist joint pain and elevated C-reactive protein (CRP) were positively associated with RF positivity, with OR of 1.02 (P = 0.024), 8.94 (P = 0.008) and 1.79 (P = 0.019), respectively. Conclusion The prevalence of positive RF in brucellosis patients with arthralgia was critical, nearly one-third of patients had RF positive. Elderly men brucellosis patients with arthralgia, wrist joint pain and elevated CRP were at high risk of positive RF. It is reminded that physicians should focus on differential diagnosis during clinical diagnosis and treatment, especially in ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 15 9 e0009749 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Siwen Zhang Jing Hu Shuqi An Mujinyan Li Fande Li Peng Zhang Xiangyi Zhang Huixin Yang Taijun Wang Jingjing Luo Fangfang Hu Jiashuo Liu Qing Zhen Prevalence and relevant factors of positive RF in brucellosis patients with arthralgia. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Background Brucellosis is a critical zoonotic disease in the world, it is the non-specific arthralgia that make brucellosis patients easily misdiagnosed as rheumatoid arthritis (RA) in endemic regions. Elevated rheumatoid factor (RF) is an essential indicator of RA, and the RF in brucellosis patients is significantly higher than healthy people. Therefore, this study further explored the distribution of RF and the relevant factors of the RF positivity in brucellosis patients with arthralgia, in order to strengthen the recognition of physicians for brucellosis patients with RF positivity, especially in brucellosis-endemic areas, so as to avoid misdiagnosis and untimely treatment that may lead to malignant outcomes. Methodology and principal findings The medical records of all 572 brucellosis inpatients were collected in the Sixth People's Hospital of Shenyang, China from 2015 to 2016. After excluding 106 patients without arthralgia, 5 patients who unwilling to perform RF testing and 16 patients with diseases that may affect RF, 445 brucellosis inpatients with arthralgia were involved in this retrospective cross-sectional study. 143 (32.1%) patients with RF >10 IU/ml were classified into the RF positive group, with an average level of 16.5[12.2, 34.7] IU/ml, of which 45 (10.1%) patients were high-positive with RF >30 IU/ml. Multivariate logistic regression model was used to further analyze the relevant factors of the RF positivity and found that age, wrist joint pain and elevated C-reactive protein (CRP) were positively associated with RF positivity, with OR of 1.02 (P = 0.024), 8.94 (P = 0.008) and 1.79 (P = 0.019), respectively. Conclusion The prevalence of positive RF in brucellosis patients with arthralgia was critical, nearly one-third of patients had RF positive. Elderly men brucellosis patients with arthralgia, wrist joint pain and elevated CRP were at high risk of positive RF. It is reminded that physicians should focus on differential diagnosis during clinical diagnosis and treatment, especially in ... |
format |
Article in Journal/Newspaper |
author |
Siwen Zhang Jing Hu Shuqi An Mujinyan Li Fande Li Peng Zhang Xiangyi Zhang Huixin Yang Taijun Wang Jingjing Luo Fangfang Hu Jiashuo Liu Qing Zhen |
author_facet |
Siwen Zhang Jing Hu Shuqi An Mujinyan Li Fande Li Peng Zhang Xiangyi Zhang Huixin Yang Taijun Wang Jingjing Luo Fangfang Hu Jiashuo Liu Qing Zhen |
author_sort |
Siwen Zhang |
title |
Prevalence and relevant factors of positive RF in brucellosis patients with arthralgia. |
title_short |
Prevalence and relevant factors of positive RF in brucellosis patients with arthralgia. |
title_full |
Prevalence and relevant factors of positive RF in brucellosis patients with arthralgia. |
title_fullStr |
Prevalence and relevant factors of positive RF in brucellosis patients with arthralgia. |
title_full_unstemmed |
Prevalence and relevant factors of positive RF in brucellosis patients with arthralgia. |
title_sort |
prevalence and relevant factors of positive rf in brucellosis patients with arthralgia. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2021 |
url |
https://doi.org/10.1371/journal.pntd.0009749 https://doaj.org/article/2bae56b5b79d4ef6841fd7d7651d72bb |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 15, Iss 9, p e0009749 (2021) |
op_relation |
https://doi.org/10.1371/journal.pntd.0009749 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0009749 https://doaj.org/article/2bae56b5b79d4ef6841fd7d7651d72bb |
op_doi |
https://doi.org/10.1371/journal.pntd.0009749 |
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PLOS Neglected Tropical Diseases |
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15 |
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9 |
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e0009749 |
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