A first case of protease codon 35 amino acid insertion in a HIV-1 subtype B sequence detected in the Bauru region, state of São Paulo, Brazil: case report

• Published in: Revista da Sociedade Brasileira de Medicina Tropical
• Main Authors: Rejane Maria Tommasini Grotto, Sílvia Maria Corvino, Lilian da Silva Reis Munhoz, Cibele Gomes Ghedini, Maria Inês de Moura Campos Pardini
• Format: Article in Journal/Newspaper
• Language: English
• Published: Sociedade Brasileira de Medicina Tropical (SBMT) 2011
• Subjects: Codon 35 da protease; HIV; Inserção; Arctic medicine. Tropical medicine; RC955-962; Arctic
• Online Access: https://doi.org/10.1590/S0037-86822011000300027; https://doaj.org/article/2baa9b79ef7a43cbaa0a98ed1e55840f

Amino acid insertions in the protease have rarely been described in HIVinfected patients. One of these insertions has recently been described in codon 35, although its impact on resistance remains unknown. This study presents a case of an HIV variant with an insertion in codon 35 of the protease, described for the first time in Bauru, State of Sao Paulo, Brazil, circulating in a 38-year-old caucasian male with asymptomatic HIV infection since 1997. The variant isolated showed a codon 35 insertion of two amino acids in the protease: a threonine and an aspartic acid, resulting in the amino acid sequence E35E_TD.