Vector saliva controlled inflammatory response of the host may represent the Achilles heel during pathogen transmission

• Published in: Journal of Venomous Animals and Toxins including Tropical Diseases
• Main Authors: Claudia Demarta-Gatsi, Salah Mécheri
• Format: Article in Journal/Newspaper
• Language: English
• Published: SciELO 2021
• Subjects: Vector saliva; Immunomodulation; Parasites; Arboviruses; Vaccine; Arctic medicine. Tropical medicine; RC955-962; Toxicology. Poisons; RA1190-1270; Zoology; QL1-991; Arctic; Achilles Heel
• Online Access: https://doi.org/10.1590/1678-9199-jvatitd-2020-0155; https://doaj.org/article/2b8d2d22b6ea4ba3a3f085ecf33183fd

Abstract Infection with vector-borne pathogens starts with the inoculation of these pathogens during blood feeding. In endemic regions, the population is regularly bitten by naive vectors, implicating a permanent stimulation of the immune system by the vector saliva itself (pre-immune context). Comp...