Identification of positively selected genes in human pathogenic treponemes: Syphilis-, yaws-, and bejel-causing strains differ in sets of genes showing adaptive evolution.

• Published in: PLOS Neglected Tropical Diseases
• Main Authors: Denisa Maděránková, Lenka Mikalová, Michal Strouhal, Šimon Vadják, Ivana Kuklová, Petra Pospíšilová, Lenka Krbková, Pavlína Koščová, Ivo Provazník, David Šmajs
• Format: Article in Journal/Newspaper
• Language: English
• Published: Public Library of Science (PLoS) 2019
• Subjects: Arctic medicine. Tropical medicine; RC955-962; Public aspects of medicine; RA1-1270; Arctic; Gauthier
• Online Access: https://doi.org/10.1371/journal.pntd.0007463; https://doaj.org/article/2b648f1ed7a94d04acc68916ef08ece0

Background Pathogenic treponemes related to Treponema pallidum are both human (causing syphilis, yaws, bejel) and animal pathogens (infections of primates, venereal spirochetosis in rabbits). A set of 11 treponemal genome sequences including those of five Treponema pallidum ssp. pallidum (TPA) strai...