Plasma organochlorine concentrations and bone ultrasound measurements: a cross-sectional study in peri-and postmenopausal Inuit women from Greenland
Abstract Background Inuit women are highly exposed through their traditional seafood based diet to organochlorine compounds, some of them displaying endocrine disrupting properties. We hypothesized that this exposure might be related to bone characteristics that are altered in osteoporosis, because...
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ftdoajarticles:oai:doaj.org/article:2aeee3a5a489454eb6b4d9204c0b5584 2023-05-15T16:28:30+02:00 Plasma organochlorine concentrations and bone ultrasound measurements: a cross-sectional study in peri-and postmenopausal Inuit women from Greenland Mulvad Gert Blanchet Claudine Dodin Sylvie Ayotte Pierre Côté Suzanne Petersen Henning S Gingras Suzanne Dewailly Éric 2006-12-01T00:00:00Z https://doi.org/10.1186/1476-069X-5-33 https://doaj.org/article/2aeee3a5a489454eb6b4d9204c0b5584 EN eng BMC http://www.ehjournal.net/content/5/1/33 https://doaj.org/toc/1476-069X doi:10.1186/1476-069X-5-33 1476-069X https://doaj.org/article/2aeee3a5a489454eb6b4d9204c0b5584 Environmental Health, Vol 5, Iss 1, p 33 (2006) Industrial medicine. Industrial hygiene RC963-969 Public aspects of medicine RA1-1270 article 2006 ftdoajarticles https://doi.org/10.1186/1476-069X-5-33 2022-12-31T02:35:41Z Abstract Background Inuit women are highly exposed through their traditional seafood based diet to organochlorine compounds, some of them displaying endocrine disrupting properties. We hypothesized that this exposure might be related to bone characteristics that are altered in osteoporosis, because hormone deficiency is a known risk factor for the disease. Methods We measured quantitative ultrasound parameters (QUS) at the right calcaneum of 153 peri- and postmenopausal Inuit women (49–64 year old) from Nuuk, Greenland, and investigated the relation between these parameters and plasma organochlorine concentrations. We used high-resolution gas chromatography with electron capture detection to analyze plasma samples for 14 polychlorinated biphenyls (PCB) congeners and 11 chlorinated pesticides and metabolites. We analysed morning urine samples for cadmium, a potential confounder, by atomic absorption spectrometry. We used a validated questionnaire to document dietary and lifestyle habits as well as reproductive and medical histories. Results Concentrations of PCB 153, a surrogate of exposure to most organochlorines present in plasma samples, were inversely correlated to QUS parameters in univariate analyses ( p < 0.001). However, PCB 153 concentrations were not associated with QUS values in multivariate analyses that comprised potential confounding factors such as age, body weight, former oral contraceptive use and current hormone replacement therapy (HRT) use, which were all significant predictors of bone stiffness (total R 2 = 0.39; p < 0.001). Conclusion Overall we found little evidence that organochlorines exposure is related to osteoporosis in Greenlandic Inuit women, but the hypothesis that exposure to dioxin-like compounds might be linked to decreased bone quality and osteoporosis deserves further attention. Article in Journal/Newspaper Greenland greenlandic inuit Nuuk Directory of Open Access Journals: DOAJ Articles Greenland Nuuk ENVELOPE(-52.150,-52.150,68.717,68.717) Environmental Health 5 1 |
institution |
Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Industrial medicine. Industrial hygiene RC963-969 Public aspects of medicine RA1-1270 |
spellingShingle |
Industrial medicine. Industrial hygiene RC963-969 Public aspects of medicine RA1-1270 Mulvad Gert Blanchet Claudine Dodin Sylvie Ayotte Pierre Côté Suzanne Petersen Henning S Gingras Suzanne Dewailly Éric Plasma organochlorine concentrations and bone ultrasound measurements: a cross-sectional study in peri-and postmenopausal Inuit women from Greenland |
topic_facet |
Industrial medicine. Industrial hygiene RC963-969 Public aspects of medicine RA1-1270 |
description |
Abstract Background Inuit women are highly exposed through their traditional seafood based diet to organochlorine compounds, some of them displaying endocrine disrupting properties. We hypothesized that this exposure might be related to bone characteristics that are altered in osteoporosis, because hormone deficiency is a known risk factor for the disease. Methods We measured quantitative ultrasound parameters (QUS) at the right calcaneum of 153 peri- and postmenopausal Inuit women (49–64 year old) from Nuuk, Greenland, and investigated the relation between these parameters and plasma organochlorine concentrations. We used high-resolution gas chromatography with electron capture detection to analyze plasma samples for 14 polychlorinated biphenyls (PCB) congeners and 11 chlorinated pesticides and metabolites. We analysed morning urine samples for cadmium, a potential confounder, by atomic absorption spectrometry. We used a validated questionnaire to document dietary and lifestyle habits as well as reproductive and medical histories. Results Concentrations of PCB 153, a surrogate of exposure to most organochlorines present in plasma samples, were inversely correlated to QUS parameters in univariate analyses ( p < 0.001). However, PCB 153 concentrations were not associated with QUS values in multivariate analyses that comprised potential confounding factors such as age, body weight, former oral contraceptive use and current hormone replacement therapy (HRT) use, which were all significant predictors of bone stiffness (total R 2 = 0.39; p < 0.001). Conclusion Overall we found little evidence that organochlorines exposure is related to osteoporosis in Greenlandic Inuit women, but the hypothesis that exposure to dioxin-like compounds might be linked to decreased bone quality and osteoporosis deserves further attention. |
format |
Article in Journal/Newspaper |
author |
Mulvad Gert Blanchet Claudine Dodin Sylvie Ayotte Pierre Côté Suzanne Petersen Henning S Gingras Suzanne Dewailly Éric |
author_facet |
Mulvad Gert Blanchet Claudine Dodin Sylvie Ayotte Pierre Côté Suzanne Petersen Henning S Gingras Suzanne Dewailly Éric |
author_sort |
Mulvad Gert |
title |
Plasma organochlorine concentrations and bone ultrasound measurements: a cross-sectional study in peri-and postmenopausal Inuit women from Greenland |
title_short |
Plasma organochlorine concentrations and bone ultrasound measurements: a cross-sectional study in peri-and postmenopausal Inuit women from Greenland |
title_full |
Plasma organochlorine concentrations and bone ultrasound measurements: a cross-sectional study in peri-and postmenopausal Inuit women from Greenland |
title_fullStr |
Plasma organochlorine concentrations and bone ultrasound measurements: a cross-sectional study in peri-and postmenopausal Inuit women from Greenland |
title_full_unstemmed |
Plasma organochlorine concentrations and bone ultrasound measurements: a cross-sectional study in peri-and postmenopausal Inuit women from Greenland |
title_sort |
plasma organochlorine concentrations and bone ultrasound measurements: a cross-sectional study in peri-and postmenopausal inuit women from greenland |
publisher |
BMC |
publishDate |
2006 |
url |
https://doi.org/10.1186/1476-069X-5-33 https://doaj.org/article/2aeee3a5a489454eb6b4d9204c0b5584 |
long_lat |
ENVELOPE(-52.150,-52.150,68.717,68.717) |
geographic |
Greenland Nuuk |
geographic_facet |
Greenland Nuuk |
genre |
Greenland greenlandic inuit Nuuk |
genre_facet |
Greenland greenlandic inuit Nuuk |
op_source |
Environmental Health, Vol 5, Iss 1, p 33 (2006) |
op_relation |
http://www.ehjournal.net/content/5/1/33 https://doaj.org/toc/1476-069X doi:10.1186/1476-069X-5-33 1476-069X https://doaj.org/article/2aeee3a5a489454eb6b4d9204c0b5584 |
op_doi |
https://doi.org/10.1186/1476-069X-5-33 |
container_title |
Environmental Health |
container_volume |
5 |
container_issue |
1 |
_version_ |
1766018157713031168 |