Antipyretic and antinociceptive activity of Diospyros lotus L. in animals

• Published in: Asian Pacific Journal of Tropical Biomedicine
• Main Authors: Abdur Rauf, Ghias Uddin, Bina S. Siddiqui, Naveed Muhammad, Haroon Khan
• Format: Article in Journal/Newspaper
• Language: English
• Published: Wolters Kluwer Medknow Publications 2014
• Subjects: Diospyros lotus; Ebenaceae; Antipyretic; Antinociceptive activities; Arctic medicine. Tropical medicine; RC955-962; Biology (General); QH301-705.5; Arctic
• Online Access: https://doi.org/10.12980/APJTB.4.2014C1020; https://doaj.org/article/2ab3acac8f3a494c9d1ce6f0b27a812b

Objective: To evaluate pharmacologically the traditional use of Diospyros lotus as antipyretic and antinociceptive in various animal models. Methods: In vivo experimental models were used in this study. Antipyretic activity of extract/fractions was evaluated in brewer's yeast induced hyperthermic mice while antinociceptive activity was studied in acetic acid induced writhing test at 50 and 100 mg/kg i.p. Results: The crude extract strongly ameliorated the induced pyrexia during various assessment times. Upon fractionation, the antipyretic effects were strongly augmented by the chloroform and ethyl acetate fractions of the plant. However, hexane and butanol fractions were insignificant in their effect as antipyretic. The extract showed marked inhibition on the noxious simulation induced by post acetic acid injection. The effect was strongly supported by other fraction expect hexane. Conclusions: In short, our study scientifically validated the traditional use of the plant as antipyretic.