Potential Use of Atlantic Cod Trypsin in Biomedicine
Surface proteins of viruses and bacteria used for cell attachment and invasion are candidates for degradation by proteases. Trypsin from Atlantic cod (Gadus morhua) was previously demonstrated to have efficacy against influenza viruses in vitro and on skin. In this paper, cod trypsin is shown to be...
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ftdoajarticles:oai:doaj.org/article:2a5abd4d5100483b99ca51c47040b1bb 2023-05-15T15:27:11+02:00 Potential Use of Atlantic Cod Trypsin in Biomedicine Ágústa Gudmundsdóttir Hilmar Hilmarsson Bjarki Stefansson 2013-01-01T00:00:00Z https://doi.org/10.1155/2013/749078 https://doaj.org/article/2a5abd4d5100483b99ca51c47040b1bb EN eng Hindawi Limited http://dx.doi.org/10.1155/2013/749078 https://doaj.org/toc/2314-6133 https://doaj.org/toc/2314-6141 2314-6133 2314-6141 doi:10.1155/2013/749078 https://doaj.org/article/2a5abd4d5100483b99ca51c47040b1bb BioMed Research International, Vol 2013 (2013) Medicine R article 2013 ftdoajarticles https://doi.org/10.1155/2013/749078 2022-12-31T15:42:24Z Surface proteins of viruses and bacteria used for cell attachment and invasion are candidates for degradation by proteases. Trypsin from Atlantic cod (Gadus morhua) was previously demonstrated to have efficacy against influenza viruses in vitro and on skin. In this paper, cod trypsin is shown to be 3–12 times more effective in degrading large native proteins than its mesophilic analogue, bovine trypsin. This is in agreement with previous findings where cod trypsin was found to be the most active among twelve different proteases in cleaving various cytokines and pathological proteins. Furthermore, our results show that cod trypsin has high efficacy against herpes simplex virus type 1 (HSV-1) and the respiratory syncytial virus (RSV) in vitro. The results on the antipathogenic properties of cod trypsin are important because rhinovirus, RSV, and influenza are the most predominant pathogenic viruses in upper respiratory tract infections. Results from a clinical study presented in this paper show that a specific formulation containing cod trypsin was preferred for wound healing over other methods used in the study. Apparently, the high digestive ability of the cold-adapted cod trypsin towards large native proteins plays a role in its efficacy against pathogens and its positive effects on wounds. Article in Journal/Newspaper atlantic cod Gadus morhua Directory of Open Access Journals: DOAJ Articles BioMed Research International 2013 1 11 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
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Medicine R |
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Medicine R Ágústa Gudmundsdóttir Hilmar Hilmarsson Bjarki Stefansson Potential Use of Atlantic Cod Trypsin in Biomedicine |
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Medicine R |
description |
Surface proteins of viruses and bacteria used for cell attachment and invasion are candidates for degradation by proteases. Trypsin from Atlantic cod (Gadus morhua) was previously demonstrated to have efficacy against influenza viruses in vitro and on skin. In this paper, cod trypsin is shown to be 3–12 times more effective in degrading large native proteins than its mesophilic analogue, bovine trypsin. This is in agreement with previous findings where cod trypsin was found to be the most active among twelve different proteases in cleaving various cytokines and pathological proteins. Furthermore, our results show that cod trypsin has high efficacy against herpes simplex virus type 1 (HSV-1) and the respiratory syncytial virus (RSV) in vitro. The results on the antipathogenic properties of cod trypsin are important because rhinovirus, RSV, and influenza are the most predominant pathogenic viruses in upper respiratory tract infections. Results from a clinical study presented in this paper show that a specific formulation containing cod trypsin was preferred for wound healing over other methods used in the study. Apparently, the high digestive ability of the cold-adapted cod trypsin towards large native proteins plays a role in its efficacy against pathogens and its positive effects on wounds. |
format |
Article in Journal/Newspaper |
author |
Ágústa Gudmundsdóttir Hilmar Hilmarsson Bjarki Stefansson |
author_facet |
Ágústa Gudmundsdóttir Hilmar Hilmarsson Bjarki Stefansson |
author_sort |
Ágústa Gudmundsdóttir |
title |
Potential Use of Atlantic Cod Trypsin in Biomedicine |
title_short |
Potential Use of Atlantic Cod Trypsin in Biomedicine |
title_full |
Potential Use of Atlantic Cod Trypsin in Biomedicine |
title_fullStr |
Potential Use of Atlantic Cod Trypsin in Biomedicine |
title_full_unstemmed |
Potential Use of Atlantic Cod Trypsin in Biomedicine |
title_sort |
potential use of atlantic cod trypsin in biomedicine |
publisher |
Hindawi Limited |
publishDate |
2013 |
url |
https://doi.org/10.1155/2013/749078 https://doaj.org/article/2a5abd4d5100483b99ca51c47040b1bb |
genre |
atlantic cod Gadus morhua |
genre_facet |
atlantic cod Gadus morhua |
op_source |
BioMed Research International, Vol 2013 (2013) |
op_relation |
http://dx.doi.org/10.1155/2013/749078 https://doaj.org/toc/2314-6133 https://doaj.org/toc/2314-6141 2314-6133 2314-6141 doi:10.1155/2013/749078 https://doaj.org/article/2a5abd4d5100483b99ca51c47040b1bb |
op_doi |
https://doi.org/10.1155/2013/749078 |
container_title |
BioMed Research International |
container_volume |
2013 |
container_start_page |
1 |
op_container_end_page |
11 |
_version_ |
1766357631962710016 |