Pancreatic involvement in co-infection visceral leishmaniasis and HIV: histological and ultrastructural aspects
The involvement of the gastrointestinal tract in the co-infection of HIV and Leishmania is rarely reported. We report the case of an HIV-infected adult man co-infected with a disseminated form of leishmaniasis involving the liver, lymph nodes, spleen and, as a feature reported for the first time in...
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Universidade de São Paulo
2001
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ftdoajarticles:oai:doaj.org/article:2a32e540933f4dc59581fec6fde99bfa 2023-05-15T15:06:30+02:00 Pancreatic involvement in co-infection visceral leishmaniasis and HIV: histological and ultrastructural aspects CHEHTER Ethel Zimberg LONGO Maria Antonieta LAUDANNA Antonio Atílio DUARTE Maria Irma Seixas 2001-01-01T00:00:00Z https://doaj.org/article/2a32e540933f4dc59581fec6fde99bfa EN PT eng por Universidade de São Paulo http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46652001000200004 https://doaj.org/toc/0036-4665 https://doaj.org/toc/1678-9946 0036-4665 1678-9946 https://doaj.org/article/2a32e540933f4dc59581fec6fde99bfa Revista do Instituto de Medicina Tropical de São Paulo, Vol 43, Iss 2, Pp 75-78 (2001) Visceral Leishmaniasis Pancreas AIDS Opportunistic infection Malnutrition Arctic medicine. Tropical medicine RC955-962 article 2001 ftdoajarticles 2023-01-08T01:26:09Z The involvement of the gastrointestinal tract in the co-infection of HIV and Leishmania is rarely reported. We report the case of an HIV-infected adult man co-infected with a disseminated form of leishmaniasis involving the liver, lymph nodes, spleen and, as a feature reported for the first time in the English literature, the pancreas. Light microscopy showed amastigote forms of Leishmania in pancreatic macrophages and immunohistochemical staining revealed antigens for Leishmania and also for HIV p24. Microscopic and ultrastructural analysis revealed severe acinar atrophy, decreased zymogen granules in the acinar cytoplasm and also nuclear abnormalities such as pyknosis, hyperchromatism and thickened chromatin. These findings might correspond to the histologic pattern of protein-energy malnutrition in the pancreas as shown in our previous study in pancreas with AIDS and no Leishmania. In this particular case, the protein-energy malnutrition may be due to cirrhosis, or, Leishmania or HIV infection or all mixed. We believe that this case represents the morphologic substratum of the protein energy malnutrition in pancreas induced by the HIV infection. Further studies are needed to elucidate these issues. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English Portuguese |
topic |
Visceral Leishmaniasis Pancreas AIDS Opportunistic infection Malnutrition Arctic medicine. Tropical medicine RC955-962 |
spellingShingle |
Visceral Leishmaniasis Pancreas AIDS Opportunistic infection Malnutrition Arctic medicine. Tropical medicine RC955-962 CHEHTER Ethel Zimberg LONGO Maria Antonieta LAUDANNA Antonio Atílio DUARTE Maria Irma Seixas Pancreatic involvement in co-infection visceral leishmaniasis and HIV: histological and ultrastructural aspects |
topic_facet |
Visceral Leishmaniasis Pancreas AIDS Opportunistic infection Malnutrition Arctic medicine. Tropical medicine RC955-962 |
description |
The involvement of the gastrointestinal tract in the co-infection of HIV and Leishmania is rarely reported. We report the case of an HIV-infected adult man co-infected with a disseminated form of leishmaniasis involving the liver, lymph nodes, spleen and, as a feature reported for the first time in the English literature, the pancreas. Light microscopy showed amastigote forms of Leishmania in pancreatic macrophages and immunohistochemical staining revealed antigens for Leishmania and also for HIV p24. Microscopic and ultrastructural analysis revealed severe acinar atrophy, decreased zymogen granules in the acinar cytoplasm and also nuclear abnormalities such as pyknosis, hyperchromatism and thickened chromatin. These findings might correspond to the histologic pattern of protein-energy malnutrition in the pancreas as shown in our previous study in pancreas with AIDS and no Leishmania. In this particular case, the protein-energy malnutrition may be due to cirrhosis, or, Leishmania or HIV infection or all mixed. We believe that this case represents the morphologic substratum of the protein energy malnutrition in pancreas induced by the HIV infection. Further studies are needed to elucidate these issues. |
format |
Article in Journal/Newspaper |
author |
CHEHTER Ethel Zimberg LONGO Maria Antonieta LAUDANNA Antonio Atílio DUARTE Maria Irma Seixas |
author_facet |
CHEHTER Ethel Zimberg LONGO Maria Antonieta LAUDANNA Antonio Atílio DUARTE Maria Irma Seixas |
author_sort |
CHEHTER Ethel Zimberg |
title |
Pancreatic involvement in co-infection visceral leishmaniasis and HIV: histological and ultrastructural aspects |
title_short |
Pancreatic involvement in co-infection visceral leishmaniasis and HIV: histological and ultrastructural aspects |
title_full |
Pancreatic involvement in co-infection visceral leishmaniasis and HIV: histological and ultrastructural aspects |
title_fullStr |
Pancreatic involvement in co-infection visceral leishmaniasis and HIV: histological and ultrastructural aspects |
title_full_unstemmed |
Pancreatic involvement in co-infection visceral leishmaniasis and HIV: histological and ultrastructural aspects |
title_sort |
pancreatic involvement in co-infection visceral leishmaniasis and hiv: histological and ultrastructural aspects |
publisher |
Universidade de São Paulo |
publishDate |
2001 |
url |
https://doaj.org/article/2a32e540933f4dc59581fec6fde99bfa |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista do Instituto de Medicina Tropical de São Paulo, Vol 43, Iss 2, Pp 75-78 (2001) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46652001000200004 https://doaj.org/toc/0036-4665 https://doaj.org/toc/1678-9946 0036-4665 1678-9946 https://doaj.org/article/2a32e540933f4dc59581fec6fde99bfa |
_version_ |
1766338093861830656 |