Chemotherapeutic efficacy of a natural combination in the treatment of mansonic schistosomiasis: an experimental study
Rashad Abdul-Ghani1, Naguiba Loutfy2, Manal Sheta3, Azza Hassan21Department of Medical Parasitology, Faculty of Medicine and Health Sciences, Sana’a University, Sana’a, Yemen; 2Tropical Health Department, High Institute of Public Health, 3Department of Pathology, Medical Research Institute, Alexandr...
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ftdoajarticles:oai:doaj.org/article:29ea3d3756894c4dbd9f58103d97cf4a 2023-05-15T15:13:19+02:00 Chemotherapeutic efficacy of a natural combination in the treatment of mansonic schistosomiasis: an experimental study Rashad Abdul-Ghani Naguiba Loutfy Manal Sheta 2011-01-01T00:00:00Z https://doaj.org/article/29ea3d3756894c4dbd9f58103d97cf4a EN eng Dove Medical Press http://www.dovepress.com/chemotherapeutic-efficacy-of-a-natural-combination-in-the-treatment-of-a6008 https://doaj.org/toc/1179-7282 1179-7282 https://doaj.org/article/29ea3d3756894c4dbd9f58103d97cf4a Research and Reports in Tropical Medicine, Vol 2011, Iss default, Pp 1-7 (2011) Arctic medicine. Tropical medicine RC955-962 article 2011 ftdoajarticles 2022-12-31T01:15:35Z Rashad Abdul-Ghani1, Naguiba Loutfy2, Manal Sheta3, Azza Hassan21Department of Medical Parasitology, Faculty of Medicine and Health Sciences, Sana’a University, Sana’a, Yemen; 2Tropical Health Department, High Institute of Public Health, 3Department of Pathology, Medical Research Institute, Alexandria University, Alexandria, EgyptPurpose: Combination chemotherapy of Schistosoma mansoni has been studied previously, with praziquantel being the basis of combination. Artemether and myrrh are compounds of a natural origin that have been investigated experimentally and clinically against schistosomiasis. Artemether is used as an antimalarial drug, and has been used as a chemoprophylactic drug against Schistosoma japonica in China whereas myrrh extract is manufactured and prescribed as an antischistosomal drug in Egypt. The present study investigated the experimental efficacy of combining artemether and myrrh using three different protocols in mice infected with the Egyptian strain of S. mansoni.Methods: Experiments were performed on 40 eight-week-old female Swiss albino mice divided into three experimental groups and one control group. Assessment of efficacy was based on a suite of parasitologic and histopathologic parameters. Parasitologic parameters included reductions in total and female worm burdens, reductions in hepatic and intestinal wall tissue egg loads, and alterations in oogram patterns in the experimental groups compared to the infected untreated control. Histopathologic parameters comprised microscopic examination of liver sections stained with hematoxylin and eosin to study the reductions in the mean counts and diameters of hepatic granulomas as well as their healing ratios compared to the control.Results: Reductions of 43.9%–58.2% in total worm burdens and 42.4%–63.7% in female worm burdens were induced. Meanwhile, significant reductions of 63.1%–77.8% in eggs per gram of small intestinal tissue and of 56.5%–66.3% in eggs per gram of liver tissue were also observed. The combination also caused ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic |
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Arctic medicine. Tropical medicine RC955-962 |
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Arctic medicine. Tropical medicine RC955-962 Rashad Abdul-Ghani Naguiba Loutfy Manal Sheta Chemotherapeutic efficacy of a natural combination in the treatment of mansonic schistosomiasis: an experimental study |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 |
description |
Rashad Abdul-Ghani1, Naguiba Loutfy2, Manal Sheta3, Azza Hassan21Department of Medical Parasitology, Faculty of Medicine and Health Sciences, Sana’a University, Sana’a, Yemen; 2Tropical Health Department, High Institute of Public Health, 3Department of Pathology, Medical Research Institute, Alexandria University, Alexandria, EgyptPurpose: Combination chemotherapy of Schistosoma mansoni has been studied previously, with praziquantel being the basis of combination. Artemether and myrrh are compounds of a natural origin that have been investigated experimentally and clinically against schistosomiasis. Artemether is used as an antimalarial drug, and has been used as a chemoprophylactic drug against Schistosoma japonica in China whereas myrrh extract is manufactured and prescribed as an antischistosomal drug in Egypt. The present study investigated the experimental efficacy of combining artemether and myrrh using three different protocols in mice infected with the Egyptian strain of S. mansoni.Methods: Experiments were performed on 40 eight-week-old female Swiss albino mice divided into three experimental groups and one control group. Assessment of efficacy was based on a suite of parasitologic and histopathologic parameters. Parasitologic parameters included reductions in total and female worm burdens, reductions in hepatic and intestinal wall tissue egg loads, and alterations in oogram patterns in the experimental groups compared to the infected untreated control. Histopathologic parameters comprised microscopic examination of liver sections stained with hematoxylin and eosin to study the reductions in the mean counts and diameters of hepatic granulomas as well as their healing ratios compared to the control.Results: Reductions of 43.9%–58.2% in total worm burdens and 42.4%–63.7% in female worm burdens were induced. Meanwhile, significant reductions of 63.1%–77.8% in eggs per gram of small intestinal tissue and of 56.5%–66.3% in eggs per gram of liver tissue were also observed. The combination also caused ... |
format |
Article in Journal/Newspaper |
author |
Rashad Abdul-Ghani Naguiba Loutfy Manal Sheta |
author_facet |
Rashad Abdul-Ghani Naguiba Loutfy Manal Sheta |
author_sort |
Rashad Abdul-Ghani |
title |
Chemotherapeutic efficacy of a natural combination in the treatment of mansonic schistosomiasis: an experimental study |
title_short |
Chemotherapeutic efficacy of a natural combination in the treatment of mansonic schistosomiasis: an experimental study |
title_full |
Chemotherapeutic efficacy of a natural combination in the treatment of mansonic schistosomiasis: an experimental study |
title_fullStr |
Chemotherapeutic efficacy of a natural combination in the treatment of mansonic schistosomiasis: an experimental study |
title_full_unstemmed |
Chemotherapeutic efficacy of a natural combination in the treatment of mansonic schistosomiasis: an experimental study |
title_sort |
chemotherapeutic efficacy of a natural combination in the treatment of mansonic schistosomiasis: an experimental study |
publisher |
Dove Medical Press |
publishDate |
2011 |
url |
https://doaj.org/article/29ea3d3756894c4dbd9f58103d97cf4a |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Research and Reports in Tropical Medicine, Vol 2011, Iss default, Pp 1-7 (2011) |
op_relation |
http://www.dovepress.com/chemotherapeutic-efficacy-of-a-natural-combination-in-the-treatment-of-a6008 https://doaj.org/toc/1179-7282 1179-7282 https://doaj.org/article/29ea3d3756894c4dbd9f58103d97cf4a |
_version_ |
1766343888006545408 |