In vitro evaluation of verapamil and other modulating agents in Brazilian chloroquine-resistant Plasmodium falciparum isolates
Verapamil, was assayed to record its modulating effect upon Brazilian Plasmodium falciparum isolates resistant to chloroquine. Other cardiovascular drugs known to be modulating agents in resistant malaria and/or multidrug-resistant neoplasias, including nifedipine, nitrendipine, diltiazem and propra...
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Sociedade Brasileira de Medicina Tropical (SBMT)
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ftdoajarticles:oai:doaj.org/article:29b2c40c4aea41e29b823cc046623826 2023-05-15T15:02:36+02:00 In vitro evaluation of verapamil and other modulating agents in Brazilian chloroquine-resistant Plasmodium falciparum isolates Carla M.S. Menezes Karin Kirchgatter Sílvia M. Di Santi Carine Savalli Fabíola G. Monteiro Gilberto A. Paula Elizabeth I. Ferreira 2003-01-01T00:00:00Z https://doaj.org/article/29b2c40c4aea41e29b823cc046623826 EN eng Sociedade Brasileira de Medicina Tropical (SBMT) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822003000100002&tlng=en https://doaj.org/toc/1678-9849 1678-9849 https://doaj.org/article/29b2c40c4aea41e29b823cc046623826 Revista da Sociedade Brasileira de Medicina Tropical, Vol 36, Iss 1, Pp 5-9 (2003) Chloroquine Multidrug-resistance Verapamil Modulating agents Reversal agents Arctic medicine. Tropical medicine RC955-962 article 2003 ftdoajarticles 2022-12-30T21:39:04Z Verapamil, was assayed to record its modulating effect upon Brazilian Plasmodium falciparum isolates resistant to chloroquine. Other cardiovascular drugs known to be modulating agents in resistant malaria and/or multidrug-resistant neoplasias, including nifedipine, nitrendipine, diltiazem and propranolol, were also evaluated. Concentrations similar to those for cardiovascular therapy were used in the in vitro microtechnique for antimalarial drug susceptibility. Intrinsic antiplasmodial activity was observed from the lowest concentrations without a significant modulating action. Other reported modulating agents, such as the antipsychotic drug trifluoperazine and the antidepressants desipramine and imipramine, demonstrated similar responses under the same experimental conditions. Results suggest a much higher susceptibility of Brazilian strains, as well as an indifferent behaviour in relation to modulating agents. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic |
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Directory of Open Access Journals: DOAJ Articles |
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English |
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Chloroquine Multidrug-resistance Verapamil Modulating agents Reversal agents Arctic medicine. Tropical medicine RC955-962 |
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Chloroquine Multidrug-resistance Verapamil Modulating agents Reversal agents Arctic medicine. Tropical medicine RC955-962 Carla M.S. Menezes Karin Kirchgatter Sílvia M. Di Santi Carine Savalli Fabíola G. Monteiro Gilberto A. Paula Elizabeth I. Ferreira In vitro evaluation of verapamil and other modulating agents in Brazilian chloroquine-resistant Plasmodium falciparum isolates |
topic_facet |
Chloroquine Multidrug-resistance Verapamil Modulating agents Reversal agents Arctic medicine. Tropical medicine RC955-962 |
description |
Verapamil, was assayed to record its modulating effect upon Brazilian Plasmodium falciparum isolates resistant to chloroquine. Other cardiovascular drugs known to be modulating agents in resistant malaria and/or multidrug-resistant neoplasias, including nifedipine, nitrendipine, diltiazem and propranolol, were also evaluated. Concentrations similar to those for cardiovascular therapy were used in the in vitro microtechnique for antimalarial drug susceptibility. Intrinsic antiplasmodial activity was observed from the lowest concentrations without a significant modulating action. Other reported modulating agents, such as the antipsychotic drug trifluoperazine and the antidepressants desipramine and imipramine, demonstrated similar responses under the same experimental conditions. Results suggest a much higher susceptibility of Brazilian strains, as well as an indifferent behaviour in relation to modulating agents. |
format |
Article in Journal/Newspaper |
author |
Carla M.S. Menezes Karin Kirchgatter Sílvia M. Di Santi Carine Savalli Fabíola G. Monteiro Gilberto A. Paula Elizabeth I. Ferreira |
author_facet |
Carla M.S. Menezes Karin Kirchgatter Sílvia M. Di Santi Carine Savalli Fabíola G. Monteiro Gilberto A. Paula Elizabeth I. Ferreira |
author_sort |
Carla M.S. Menezes |
title |
In vitro evaluation of verapamil and other modulating agents in Brazilian chloroquine-resistant Plasmodium falciparum isolates |
title_short |
In vitro evaluation of verapamil and other modulating agents in Brazilian chloroquine-resistant Plasmodium falciparum isolates |
title_full |
In vitro evaluation of verapamil and other modulating agents in Brazilian chloroquine-resistant Plasmodium falciparum isolates |
title_fullStr |
In vitro evaluation of verapamil and other modulating agents in Brazilian chloroquine-resistant Plasmodium falciparum isolates |
title_full_unstemmed |
In vitro evaluation of verapamil and other modulating agents in Brazilian chloroquine-resistant Plasmodium falciparum isolates |
title_sort |
in vitro evaluation of verapamil and other modulating agents in brazilian chloroquine-resistant plasmodium falciparum isolates |
publisher |
Sociedade Brasileira de Medicina Tropical (SBMT) |
publishDate |
2003 |
url |
https://doaj.org/article/29b2c40c4aea41e29b823cc046623826 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista da Sociedade Brasileira de Medicina Tropical, Vol 36, Iss 1, Pp 5-9 (2003) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822003000100002&tlng=en https://doaj.org/toc/1678-9849 1678-9849 https://doaj.org/article/29b2c40c4aea41e29b823cc046623826 |
_version_ |
1766334535969013760 |