Taking a bite out of nutrition and arbovirus infection.
Nutrition is a key factor in host-pathogen defense. Malnutrition can increase both host susceptibility and severity of infection through a number of pathways, and infection itself can promote nutritional deterioration and further susceptibility. Nutritional status can also strongly influence respons...
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ftdoajarticles:oai:doaj.org/article:29a78e88eb5e4ac8858c43f46d4ce966 2023-05-15T15:04:07+02:00 Taking a bite out of nutrition and arbovirus infection. James Weger-Lucarelli Heidi Auerswald Marco Vignuzzi Phillipe Dussart Erik A Karlsson 2018-03-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0006247 https://doaj.org/article/29a78e88eb5e4ac8858c43f46d4ce966 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC5875747?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0006247 https://doaj.org/article/29a78e88eb5e4ac8858c43f46d4ce966 PLoS Neglected Tropical Diseases, Vol 12, Iss 3, p e0006247 (2018) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2018 ftdoajarticles https://doi.org/10.1371/journal.pntd.0006247 2023-01-08T01:24:30Z Nutrition is a key factor in host-pathogen defense. Malnutrition can increase both host susceptibility and severity of infection through a number of pathways, and infection itself can promote nutritional deterioration and further susceptibility. Nutritional status can also strongly influence response to vaccination or therapeutic pharmaceuticals. Arthropod-borne viruses (arboviruses) have a long history of infecting humans, resulting in regular pandemics as well as an increasing frequency of autochthonous transmission. Interestingly, aside from host-related factors, nutrition could also play a role in the competence of vectors required for transmission of these viruses. Nutritional status of the host and vector could even influence viral evolution itself. Therefore, it is vital to understand the role of nutrition in the arbovirus lifecycle. This Review will focus on nutritional factors that could influence susceptibility and severity of infection in the host, response to prophylactic and therapeutic strategies, vector competence, and viral evolution. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 12 3 e0006247 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 James Weger-Lucarelli Heidi Auerswald Marco Vignuzzi Phillipe Dussart Erik A Karlsson Taking a bite out of nutrition and arbovirus infection. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Nutrition is a key factor in host-pathogen defense. Malnutrition can increase both host susceptibility and severity of infection through a number of pathways, and infection itself can promote nutritional deterioration and further susceptibility. Nutritional status can also strongly influence response to vaccination or therapeutic pharmaceuticals. Arthropod-borne viruses (arboviruses) have a long history of infecting humans, resulting in regular pandemics as well as an increasing frequency of autochthonous transmission. Interestingly, aside from host-related factors, nutrition could also play a role in the competence of vectors required for transmission of these viruses. Nutritional status of the host and vector could even influence viral evolution itself. Therefore, it is vital to understand the role of nutrition in the arbovirus lifecycle. This Review will focus on nutritional factors that could influence susceptibility and severity of infection in the host, response to prophylactic and therapeutic strategies, vector competence, and viral evolution. |
format |
Article in Journal/Newspaper |
author |
James Weger-Lucarelli Heidi Auerswald Marco Vignuzzi Phillipe Dussart Erik A Karlsson |
author_facet |
James Weger-Lucarelli Heidi Auerswald Marco Vignuzzi Phillipe Dussart Erik A Karlsson |
author_sort |
James Weger-Lucarelli |
title |
Taking a bite out of nutrition and arbovirus infection. |
title_short |
Taking a bite out of nutrition and arbovirus infection. |
title_full |
Taking a bite out of nutrition and arbovirus infection. |
title_fullStr |
Taking a bite out of nutrition and arbovirus infection. |
title_full_unstemmed |
Taking a bite out of nutrition and arbovirus infection. |
title_sort |
taking a bite out of nutrition and arbovirus infection. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2018 |
url |
https://doi.org/10.1371/journal.pntd.0006247 https://doaj.org/article/29a78e88eb5e4ac8858c43f46d4ce966 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 12, Iss 3, p e0006247 (2018) |
op_relation |
http://europepmc.org/articles/PMC5875747?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0006247 https://doaj.org/article/29a78e88eb5e4ac8858c43f46d4ce966 |
op_doi |
https://doi.org/10.1371/journal.pntd.0006247 |
container_title |
PLOS Neglected Tropical Diseases |
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12 |
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3 |
container_start_page |
e0006247 |
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1766335927031955456 |