Early life microbial exposures shape the Crassostrea gigas immune system for lifelong and intergenerational disease protection
Abstract Background The interaction of organisms with their surrounding microbial communities influences many biological processes, a notable example of which is the shaping of the immune system in early life. In the Pacific oyster, Crassostrea gigas, the role of the environmental microbial communit...
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ftdoajarticles:oai:doaj.org/article:297fecc7f9314cc98ea991c74702f997 2023-05-15T15:57:52+02:00 Early life microbial exposures shape the Crassostrea gigas immune system for lifelong and intergenerational disease protection Manon Fallet Caroline Montagnani Bruno Petton Luc Dantan Julien de Lorgeril Sébastien Comarmond Cristian Chaparro Eve Toulza Simon Boitard Jean-Michel Escoubas Agnès Vergnes Jacqueline Le Grand Ingo Bulla Yannick Gueguen Jérémie Vidal-Dupiol Christoph Grunau Guillaume Mitta Céline Cosseau 2022-06-01T00:00:00Z https://doi.org/10.1186/s40168-022-01280-5 https://doaj.org/article/297fecc7f9314cc98ea991c74702f997 EN eng BMC https://doi.org/10.1186/s40168-022-01280-5 https://doaj.org/toc/2049-2618 doi:10.1186/s40168-022-01280-5 2049-2618 https://doaj.org/article/297fecc7f9314cc98ea991c74702f997 Microbiome, Vol 10, Iss 1, Pp 1-21 (2022) Oyster Aquaculture Microbiota Innate immune shaping Epigenetic DNA methylation Microbial ecology QR100-130 article 2022 ftdoajarticles https://doi.org/10.1186/s40168-022-01280-5 2022-12-30T21:37:09Z Abstract Background The interaction of organisms with their surrounding microbial communities influences many biological processes, a notable example of which is the shaping of the immune system in early life. In the Pacific oyster, Crassostrea gigas, the role of the environmental microbial community on immune system maturation — and, importantly, protection from infectious disease — is still an open question. Results Here, we demonstrate that early life microbial exposure durably improves oyster survival when challenged with the pathogen causing Pacific oyster mortality syndrome (POMS), both in the exposed generation and in the subsequent one. Combining microbiota, transcriptomic, genetic, and epigenetic analyses, we show that the microbial exposure induced changes in epigenetic marks and a reprogramming of immune gene expression leading to long-term and intergenerational immune protection against POMS. Conclusions We anticipate that this protection likely extends to additional pathogens and may prove to be an important new strategy for safeguarding oyster aquaculture efforts from infectious disease. tag the videobyte/videoabstract in this section Video Abstract Article in Journal/Newspaper Crassostrea gigas Pacific oyster Directory of Open Access Journals: DOAJ Articles Pacific Microbiome 10 1 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Oyster Aquaculture Microbiota Innate immune shaping Epigenetic DNA methylation Microbial ecology QR100-130 |
spellingShingle |
Oyster Aquaculture Microbiota Innate immune shaping Epigenetic DNA methylation Microbial ecology QR100-130 Manon Fallet Caroline Montagnani Bruno Petton Luc Dantan Julien de Lorgeril Sébastien Comarmond Cristian Chaparro Eve Toulza Simon Boitard Jean-Michel Escoubas Agnès Vergnes Jacqueline Le Grand Ingo Bulla Yannick Gueguen Jérémie Vidal-Dupiol Christoph Grunau Guillaume Mitta Céline Cosseau Early life microbial exposures shape the Crassostrea gigas immune system for lifelong and intergenerational disease protection |
topic_facet |
Oyster Aquaculture Microbiota Innate immune shaping Epigenetic DNA methylation Microbial ecology QR100-130 |
description |
Abstract Background The interaction of organisms with their surrounding microbial communities influences many biological processes, a notable example of which is the shaping of the immune system in early life. In the Pacific oyster, Crassostrea gigas, the role of the environmental microbial community on immune system maturation — and, importantly, protection from infectious disease — is still an open question. Results Here, we demonstrate that early life microbial exposure durably improves oyster survival when challenged with the pathogen causing Pacific oyster mortality syndrome (POMS), both in the exposed generation and in the subsequent one. Combining microbiota, transcriptomic, genetic, and epigenetic analyses, we show that the microbial exposure induced changes in epigenetic marks and a reprogramming of immune gene expression leading to long-term and intergenerational immune protection against POMS. Conclusions We anticipate that this protection likely extends to additional pathogens and may prove to be an important new strategy for safeguarding oyster aquaculture efforts from infectious disease. tag the videobyte/videoabstract in this section Video Abstract |
format |
Article in Journal/Newspaper |
author |
Manon Fallet Caroline Montagnani Bruno Petton Luc Dantan Julien de Lorgeril Sébastien Comarmond Cristian Chaparro Eve Toulza Simon Boitard Jean-Michel Escoubas Agnès Vergnes Jacqueline Le Grand Ingo Bulla Yannick Gueguen Jérémie Vidal-Dupiol Christoph Grunau Guillaume Mitta Céline Cosseau |
author_facet |
Manon Fallet Caroline Montagnani Bruno Petton Luc Dantan Julien de Lorgeril Sébastien Comarmond Cristian Chaparro Eve Toulza Simon Boitard Jean-Michel Escoubas Agnès Vergnes Jacqueline Le Grand Ingo Bulla Yannick Gueguen Jérémie Vidal-Dupiol Christoph Grunau Guillaume Mitta Céline Cosseau |
author_sort |
Manon Fallet |
title |
Early life microbial exposures shape the Crassostrea gigas immune system for lifelong and intergenerational disease protection |
title_short |
Early life microbial exposures shape the Crassostrea gigas immune system for lifelong and intergenerational disease protection |
title_full |
Early life microbial exposures shape the Crassostrea gigas immune system for lifelong and intergenerational disease protection |
title_fullStr |
Early life microbial exposures shape the Crassostrea gigas immune system for lifelong and intergenerational disease protection |
title_full_unstemmed |
Early life microbial exposures shape the Crassostrea gigas immune system for lifelong and intergenerational disease protection |
title_sort |
early life microbial exposures shape the crassostrea gigas immune system for lifelong and intergenerational disease protection |
publisher |
BMC |
publishDate |
2022 |
url |
https://doi.org/10.1186/s40168-022-01280-5 https://doaj.org/article/297fecc7f9314cc98ea991c74702f997 |
geographic |
Pacific |
geographic_facet |
Pacific |
genre |
Crassostrea gigas Pacific oyster |
genre_facet |
Crassostrea gigas Pacific oyster |
op_source |
Microbiome, Vol 10, Iss 1, Pp 1-21 (2022) |
op_relation |
https://doi.org/10.1186/s40168-022-01280-5 https://doaj.org/toc/2049-2618 doi:10.1186/s40168-022-01280-5 2049-2618 https://doaj.org/article/297fecc7f9314cc98ea991c74702f997 |
op_doi |
https://doi.org/10.1186/s40168-022-01280-5 |
container_title |
Microbiome |
container_volume |
10 |
container_issue |
1 |
_version_ |
1766393572914888704 |