HLA Genotypes in Patients with Infection Caused by Different Strains of SARS-CoV-2
The aggressive infectious nature of SARS-CoV-2, its rapid spread, and the emergence of mutations necessitate investigation of factors contributing to differences in SARS-CoV-2 susceptibility and severity. The role of genetic variations in the human HLA continues to be studied in various populations...
Published in: | International Journal of Environmental Research and Public Health |
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Online Access: | https://doi.org/10.3390/ijerph192114024 https://doaj.org/article/29420c8c02944c2d8a5fd701407bef13 |
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ftdoajarticles:oai:doaj.org/article:29420c8c02944c2d8a5fd701407bef13 2023-05-15T17:46:04+02:00 HLA Genotypes in Patients with Infection Caused by Different Strains of SARS-CoV-2 Ludmila Bubnova Irina Pavlova Maria Terentieva Tatiana Glazanova Elena Belyaeva Sergei Sidorkevich Nataliya Bashketova Irina Chkhingeria Mal’vina Kozhemyakina Daniil Azarov Raisa Kuznetsova Edward S. Ramsay Anna Gladkikh Alena Sharova Vladimir Dedkov Areg Totolian 2022-10-01T00:00:00Z https://doi.org/10.3390/ijerph192114024 https://doaj.org/article/29420c8c02944c2d8a5fd701407bef13 EN eng MDPI AG https://www.mdpi.com/1660-4601/19/21/14024 https://doaj.org/toc/1661-7827 https://doaj.org/toc/1660-4601 doi:10.3390/ijerph192114024 1660-4601 1661-7827 https://doaj.org/article/29420c8c02944c2d8a5fd701407bef13 International Journal of Environmental Research and Public Health, Vol 19, Iss 14024, p 14024 (2022) COVID-19 HLA northwestern federal district Russia variants of concern Medicine R article 2022 ftdoajarticles https://doi.org/10.3390/ijerph192114024 2022-12-30T21:27:08Z The aggressive infectious nature of SARS-CoV-2, its rapid spread, and the emergence of mutations necessitate investigation of factors contributing to differences in SARS-CoV-2 susceptibility and severity. The role of genetic variations in the human HLA continues to be studied in various populations in terms of both its effect on morbidity and clinical manifestation of illness. The study included 484 COVID-19 convalescents (northwest Russia residents of St. Petersburg). Cases in which the responsible strain was determined were divided in two subgroups: group 1 ( n = 231) had illness caused by genovariants unrelated to variant of concern (VOC) strains; and group 2 ( n = 80) had illness caused by the delta (B.1.617.2) VOC; and a control group ( n = 1456). DNA typing (HLA-A, B, DRB1) was performed at the basic resolution level. HLA-A*02 was associated with protection against infection caused by non-VOC SARS-CoV-2 genetic variants only but not against infection caused by delta strains. HLA-A*03 was associated with protection against infection caused by delta strains; and allele groups associated with infection by delta strains were HLA-A*30, B*49, and B*57. Thus, in northwest Russia, HLA-A*02 was associated with protection against infection caused by non-VOC SARS-CoV-2 genetic variants but not against delta viral strains. HLA-A*03 was associated with a reduced risk of infection by delta SARS-CoV-2 strains. HLA-A*30, HLA-B*49, and HLA-B*57 allele groups were predisposing factors for infection by delta (B.1.617.2) strains. Article in Journal/Newspaper Northwest Russia Directory of Open Access Journals: DOAJ Articles International Journal of Environmental Research and Public Health 19 21 14024 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
COVID-19 HLA northwestern federal district Russia variants of concern Medicine R |
spellingShingle |
COVID-19 HLA northwestern federal district Russia variants of concern Medicine R Ludmila Bubnova Irina Pavlova Maria Terentieva Tatiana Glazanova Elena Belyaeva Sergei Sidorkevich Nataliya Bashketova Irina Chkhingeria Mal’vina Kozhemyakina Daniil Azarov Raisa Kuznetsova Edward S. Ramsay Anna Gladkikh Alena Sharova Vladimir Dedkov Areg Totolian HLA Genotypes in Patients with Infection Caused by Different Strains of SARS-CoV-2 |
topic_facet |
COVID-19 HLA northwestern federal district Russia variants of concern Medicine R |
description |
The aggressive infectious nature of SARS-CoV-2, its rapid spread, and the emergence of mutations necessitate investigation of factors contributing to differences in SARS-CoV-2 susceptibility and severity. The role of genetic variations in the human HLA continues to be studied in various populations in terms of both its effect on morbidity and clinical manifestation of illness. The study included 484 COVID-19 convalescents (northwest Russia residents of St. Petersburg). Cases in which the responsible strain was determined were divided in two subgroups: group 1 ( n = 231) had illness caused by genovariants unrelated to variant of concern (VOC) strains; and group 2 ( n = 80) had illness caused by the delta (B.1.617.2) VOC; and a control group ( n = 1456). DNA typing (HLA-A, B, DRB1) was performed at the basic resolution level. HLA-A*02 was associated with protection against infection caused by non-VOC SARS-CoV-2 genetic variants only but not against infection caused by delta strains. HLA-A*03 was associated with protection against infection caused by delta strains; and allele groups associated with infection by delta strains were HLA-A*30, B*49, and B*57. Thus, in northwest Russia, HLA-A*02 was associated with protection against infection caused by non-VOC SARS-CoV-2 genetic variants but not against delta viral strains. HLA-A*03 was associated with a reduced risk of infection by delta SARS-CoV-2 strains. HLA-A*30, HLA-B*49, and HLA-B*57 allele groups were predisposing factors for infection by delta (B.1.617.2) strains. |
format |
Article in Journal/Newspaper |
author |
Ludmila Bubnova Irina Pavlova Maria Terentieva Tatiana Glazanova Elena Belyaeva Sergei Sidorkevich Nataliya Bashketova Irina Chkhingeria Mal’vina Kozhemyakina Daniil Azarov Raisa Kuznetsova Edward S. Ramsay Anna Gladkikh Alena Sharova Vladimir Dedkov Areg Totolian |
author_facet |
Ludmila Bubnova Irina Pavlova Maria Terentieva Tatiana Glazanova Elena Belyaeva Sergei Sidorkevich Nataliya Bashketova Irina Chkhingeria Mal’vina Kozhemyakina Daniil Azarov Raisa Kuznetsova Edward S. Ramsay Anna Gladkikh Alena Sharova Vladimir Dedkov Areg Totolian |
author_sort |
Ludmila Bubnova |
title |
HLA Genotypes in Patients with Infection Caused by Different Strains of SARS-CoV-2 |
title_short |
HLA Genotypes in Patients with Infection Caused by Different Strains of SARS-CoV-2 |
title_full |
HLA Genotypes in Patients with Infection Caused by Different Strains of SARS-CoV-2 |
title_fullStr |
HLA Genotypes in Patients with Infection Caused by Different Strains of SARS-CoV-2 |
title_full_unstemmed |
HLA Genotypes in Patients with Infection Caused by Different Strains of SARS-CoV-2 |
title_sort |
hla genotypes in patients with infection caused by different strains of sars-cov-2 |
publisher |
MDPI AG |
publishDate |
2022 |
url |
https://doi.org/10.3390/ijerph192114024 https://doaj.org/article/29420c8c02944c2d8a5fd701407bef13 |
genre |
Northwest Russia |
genre_facet |
Northwest Russia |
op_source |
International Journal of Environmental Research and Public Health, Vol 19, Iss 14024, p 14024 (2022) |
op_relation |
https://www.mdpi.com/1660-4601/19/21/14024 https://doaj.org/toc/1661-7827 https://doaj.org/toc/1660-4601 doi:10.3390/ijerph192114024 1660-4601 1661-7827 https://doaj.org/article/29420c8c02944c2d8a5fd701407bef13 |
op_doi |
https://doi.org/10.3390/ijerph192114024 |
container_title |
International Journal of Environmental Research and Public Health |
container_volume |
19 |
container_issue |
21 |
container_start_page |
14024 |
_version_ |
1766149411159670784 |