Feasibility and early toxicity of intraoperative radiotherapy for breast cancer using the papillon + system: First results
Background and Purpose: Breast intra operative radiation therapy has been evaluated with different systems delivering 20–21 Gy with treatment times around 30 min. Papillon + TM Contact X-ray machine was designed to produce a 50 kVp beam with a high dose rate ≥ 15 Gy/minute. A pilot study with the fi...
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ftdoajarticles:oai:doaj.org/article:28ed8f926065458fb47fa824cc6519b8 2023-05-15T18:23:01+02:00 Feasibility and early toxicity of intraoperative radiotherapy for breast cancer using the papillon + system: First results Marie-Eve Chand-Fouché Claudine Colnard Jocelyn Gal Daniel Lam Cham Kee Catherine Dejean Matthieu Gautier Julien Feuillade Aurélia Mana Yves Fouché Yann Delpech Magali Dejode Jean-Pierre Gérard Emmanuel Barranger 2023-01-01T00:00:00Z https://doi.org/10.1016/j.ctro.2022.10.006 https://doaj.org/article/28ed8f926065458fb47fa824cc6519b8 EN eng Elsevier http://www.sciencedirect.com/science/article/pii/S2405630822000908 https://doaj.org/toc/2405-6308 2405-6308 doi:10.1016/j.ctro.2022.10.006 https://doaj.org/article/28ed8f926065458fb47fa824cc6519b8 Clinical and Translational Radiation Oncology, Vol 38, Iss , Pp 47-52 (2023) Papillon+ system Breast IORT Brachytherapy High dose rate Medical physics. Medical radiology. Nuclear medicine R895-920 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 article 2023 ftdoajarticles https://doi.org/10.1016/j.ctro.2022.10.006 2022-12-30T19:36:44Z Background and Purpose: Breast intra operative radiation therapy has been evaluated with different systems delivering 20–21 Gy with treatment times around 30 min. Papillon + TM Contact X-ray machine was designed to produce a 50 kVp beam with a high dose rate ≥ 15 Gy/minute. A pilot study with the first prototype was conducted in Nice. Materials and methods: The inclusion criteria were age ≥ 60 years, unifocal ductal breast adenocarcinoma ≤ 2.5 cm, grade 1–2. Surgical local excision with sentinel node dissection was performed and the applicator was placed in the tumor bed after excision with a prescribed dose of 20 Gy. The main end point of the study was the doses measured with the Gafchromic films; two were located at the skin surface and two in the excision cavity. Secondary endpoints were early toxicity and relapse free survival. Results: Between 10/2018 and 09/2019, 26 patients were included. Mean Gafchromic doses were 18.8 Gy ± 2 Gy at the south pole, 15.6 Gy ± 2.81 Gy at the equator and 2.5 Gy ± 1.67 Gy at the skin. With a median follow-up time of 12 months, no skin or subcutaneous toxicity > grade 2, no local relapse and no metastasis were observed. Conclusion: This is the first phase II study testing the Papillon + tm system for breast IORT with in vivo dosimetry measurements and reassuring clinical data. Article in Journal/Newspaper South pole Directory of Open Access Journals: DOAJ Articles South Pole Clinical and Translational Radiation Oncology 38 47 52 |
institution |
Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Papillon+ system Breast IORT Brachytherapy High dose rate Medical physics. Medical radiology. Nuclear medicine R895-920 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 |
spellingShingle |
Papillon+ system Breast IORT Brachytherapy High dose rate Medical physics. Medical radiology. Nuclear medicine R895-920 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Marie-Eve Chand-Fouché Claudine Colnard Jocelyn Gal Daniel Lam Cham Kee Catherine Dejean Matthieu Gautier Julien Feuillade Aurélia Mana Yves Fouché Yann Delpech Magali Dejode Jean-Pierre Gérard Emmanuel Barranger Feasibility and early toxicity of intraoperative radiotherapy for breast cancer using the papillon + system: First results |
topic_facet |
Papillon+ system Breast IORT Brachytherapy High dose rate Medical physics. Medical radiology. Nuclear medicine R895-920 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 |
description |
Background and Purpose: Breast intra operative radiation therapy has been evaluated with different systems delivering 20–21 Gy with treatment times around 30 min. Papillon + TM Contact X-ray machine was designed to produce a 50 kVp beam with a high dose rate ≥ 15 Gy/minute. A pilot study with the first prototype was conducted in Nice. Materials and methods: The inclusion criteria were age ≥ 60 years, unifocal ductal breast adenocarcinoma ≤ 2.5 cm, grade 1–2. Surgical local excision with sentinel node dissection was performed and the applicator was placed in the tumor bed after excision with a prescribed dose of 20 Gy. The main end point of the study was the doses measured with the Gafchromic films; two were located at the skin surface and two in the excision cavity. Secondary endpoints were early toxicity and relapse free survival. Results: Between 10/2018 and 09/2019, 26 patients were included. Mean Gafchromic doses were 18.8 Gy ± 2 Gy at the south pole, 15.6 Gy ± 2.81 Gy at the equator and 2.5 Gy ± 1.67 Gy at the skin. With a median follow-up time of 12 months, no skin or subcutaneous toxicity > grade 2, no local relapse and no metastasis were observed. Conclusion: This is the first phase II study testing the Papillon + tm system for breast IORT with in vivo dosimetry measurements and reassuring clinical data. |
format |
Article in Journal/Newspaper |
author |
Marie-Eve Chand-Fouché Claudine Colnard Jocelyn Gal Daniel Lam Cham Kee Catherine Dejean Matthieu Gautier Julien Feuillade Aurélia Mana Yves Fouché Yann Delpech Magali Dejode Jean-Pierre Gérard Emmanuel Barranger |
author_facet |
Marie-Eve Chand-Fouché Claudine Colnard Jocelyn Gal Daniel Lam Cham Kee Catherine Dejean Matthieu Gautier Julien Feuillade Aurélia Mana Yves Fouché Yann Delpech Magali Dejode Jean-Pierre Gérard Emmanuel Barranger |
author_sort |
Marie-Eve Chand-Fouché |
title |
Feasibility and early toxicity of intraoperative radiotherapy for breast cancer using the papillon + system: First results |
title_short |
Feasibility and early toxicity of intraoperative radiotherapy for breast cancer using the papillon + system: First results |
title_full |
Feasibility and early toxicity of intraoperative radiotherapy for breast cancer using the papillon + system: First results |
title_fullStr |
Feasibility and early toxicity of intraoperative radiotherapy for breast cancer using the papillon + system: First results |
title_full_unstemmed |
Feasibility and early toxicity of intraoperative radiotherapy for breast cancer using the papillon + system: First results |
title_sort |
feasibility and early toxicity of intraoperative radiotherapy for breast cancer using the papillon + system: first results |
publisher |
Elsevier |
publishDate |
2023 |
url |
https://doi.org/10.1016/j.ctro.2022.10.006 https://doaj.org/article/28ed8f926065458fb47fa824cc6519b8 |
geographic |
South Pole |
geographic_facet |
South Pole |
genre |
South pole |
genre_facet |
South pole |
op_source |
Clinical and Translational Radiation Oncology, Vol 38, Iss , Pp 47-52 (2023) |
op_relation |
http://www.sciencedirect.com/science/article/pii/S2405630822000908 https://doaj.org/toc/2405-6308 2405-6308 doi:10.1016/j.ctro.2022.10.006 https://doaj.org/article/28ed8f926065458fb47fa824cc6519b8 |
op_doi |
https://doi.org/10.1016/j.ctro.2022.10.006 |
container_title |
Clinical and Translational Radiation Oncology |
container_volume |
38 |
container_start_page |
47 |
op_container_end_page |
52 |
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1766202436728389632 |