Clinical and laboratorial features of oral candidiasis in HIV-positive patients

• Published in: Revista da Sociedade Brasileira de Medicina Tropical
• Main Authors: Regiane Nogueira Spalanzani, Karine Mattos, Luiza Inahe Marques, Pedro Fernando Diniz Barros, Pamela Iruama Peres Pereira, Anamaria Mello Miranda Paniago, Rinaldo Poncio Mendes, Marilene Rodrigues Chang
• Format: Article in Journal/Newspaper
• Language: English
• Published: Sociedade Brasileira de Medicina Tropical (SBMT)
• Subjects: Candida spp; HIV; Antifungal susceptibility; Arctic medicine. Tropical medicine; RC955-962; Arctic
• Online Access: https://doi.org/10.1590/0037-8682-0241-2017; https://doaj.org/article/28cc213190674656868e902fa375110b

Abstract INTRODUCTION We describe the clinical and laboratorial features of oral candidiasis in 66 HIV-positive patients. METHODS: Polymerase chain reaction-based techniques were performed for differentiation of Candida spp. isolated from patients at a public teaching hospital in Midwest Brazil. RESULTS: Oral lesions, mainly pseudomembranous, were significantly related to higher levels of immunosuppression. Of 45 Candida isolates, 66.7% were C. albicans. Most of the isolates were susceptible to the antifungal drugs tested. CONCLUSIONS: Oral lesions were associated with higher immunosuppression levels. Lower susceptibility to antifungals by non-albicans isolates supports the importance of surveillance studies using susceptibility tests to aid in the treatment.