IL-4, IL-10, CCL2 and TGF-β as potential biomarkers for severity in Plasmodium vivax malaria.
Cytokines and chemokines are immune response molecules that display diverse functions, such as inflammation and immune regulation. In Plasmodium vivax infections, the uncontrolled production of these molecules is thought to contribute to pathogenesis and has been proposed as a possible predictor for...
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ftdoajarticles:oai:doaj.org/article:28bb6c3106e04ebc9c3e3fbf5cc692a2 2023-05-15T15:13:56+02:00 IL-4, IL-10, CCL2 and TGF-β as potential biomarkers for severity in Plasmodium vivax malaria. Catalina Tovar Acero Javier Ramírez-Montoya María Camila Velasco Paula A Avilés-Vergara Dina Ricardo-Caldera Miquel Duran-Frigola Gustavo Quintero Myriam Elena Cantero Juan Rivera-Correa Ana Rodriguez María Fernanda Yasnot-Acosta 2022-09-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0010798 https://doaj.org/article/28bb6c3106e04ebc9c3e3fbf5cc692a2 EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0010798 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0010798 https://doaj.org/article/28bb6c3106e04ebc9c3e3fbf5cc692a2 PLoS Neglected Tropical Diseases, Vol 16, Iss 9, p e0010798 (2022) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2022 ftdoajarticles https://doi.org/10.1371/journal.pntd.0010798 2022-12-30T19:46:11Z Cytokines and chemokines are immune response molecules that display diverse functions, such as inflammation and immune regulation. In Plasmodium vivax infections, the uncontrolled production of these molecules is thought to contribute to pathogenesis and has been proposed as a possible predictor for disease complications. The objective of this study was to evaluate the cytokine profile of P. vivax malaria patients with different clinical outcomes to identify possible immune biomarkers for severe P. vivax malaria. The study included patients with non-severe (n = 56), or severe (n = 50) P. vivax malaria and healthy controls (n = 50). Patient plasma concentrations of IL-4, IL-2, CXCL10, IL-1β, TNF-α, CCL2, IL-17A, IL-6, IL-10, IFN-γ, IL-12p70, CXCL8 and active TGF-β1 were determined through flow cytometry. The levels of several cytokines and chemokines, CXCL10, IL-10, IL-6, IL-4, CCL2 and IFN-γ were found to be significantly higher in severe, compared to non-severe P. vivax malaria patients. Severe thrombocytopenia was positively correlated with IL-4, CXCL10, IL-6, IL-10 and IFN-γ levels, renal dysfunction was related to an increase in IL-2, IL-1β, IL-17A and IL-8, and hepatic impairment with CXCL10, MCP-1, IL-6 and IFN-γ. A Lasso regression model suggests that IL-4, IL-10, CCL2 and TGF-β might be developed as biomarkers for severity in P. vivax malaria. Severe P. vivax malaria patients present specific cytokine and chemokine profiles that are different from non-severe patients and that could potentially be developed as biomarkers for disease severity. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 16 9 e0010798 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
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English |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Catalina Tovar Acero Javier Ramírez-Montoya María Camila Velasco Paula A Avilés-Vergara Dina Ricardo-Caldera Miquel Duran-Frigola Gustavo Quintero Myriam Elena Cantero Juan Rivera-Correa Ana Rodriguez María Fernanda Yasnot-Acosta IL-4, IL-10, CCL2 and TGF-β as potential biomarkers for severity in Plasmodium vivax malaria. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Cytokines and chemokines are immune response molecules that display diverse functions, such as inflammation and immune regulation. In Plasmodium vivax infections, the uncontrolled production of these molecules is thought to contribute to pathogenesis and has been proposed as a possible predictor for disease complications. The objective of this study was to evaluate the cytokine profile of P. vivax malaria patients with different clinical outcomes to identify possible immune biomarkers for severe P. vivax malaria. The study included patients with non-severe (n = 56), or severe (n = 50) P. vivax malaria and healthy controls (n = 50). Patient plasma concentrations of IL-4, IL-2, CXCL10, IL-1β, TNF-α, CCL2, IL-17A, IL-6, IL-10, IFN-γ, IL-12p70, CXCL8 and active TGF-β1 were determined through flow cytometry. The levels of several cytokines and chemokines, CXCL10, IL-10, IL-6, IL-4, CCL2 and IFN-γ were found to be significantly higher in severe, compared to non-severe P. vivax malaria patients. Severe thrombocytopenia was positively correlated with IL-4, CXCL10, IL-6, IL-10 and IFN-γ levels, renal dysfunction was related to an increase in IL-2, IL-1β, IL-17A and IL-8, and hepatic impairment with CXCL10, MCP-1, IL-6 and IFN-γ. A Lasso regression model suggests that IL-4, IL-10, CCL2 and TGF-β might be developed as biomarkers for severity in P. vivax malaria. Severe P. vivax malaria patients present specific cytokine and chemokine profiles that are different from non-severe patients and that could potentially be developed as biomarkers for disease severity. |
format |
Article in Journal/Newspaper |
author |
Catalina Tovar Acero Javier Ramírez-Montoya María Camila Velasco Paula A Avilés-Vergara Dina Ricardo-Caldera Miquel Duran-Frigola Gustavo Quintero Myriam Elena Cantero Juan Rivera-Correa Ana Rodriguez María Fernanda Yasnot-Acosta |
author_facet |
Catalina Tovar Acero Javier Ramírez-Montoya María Camila Velasco Paula A Avilés-Vergara Dina Ricardo-Caldera Miquel Duran-Frigola Gustavo Quintero Myriam Elena Cantero Juan Rivera-Correa Ana Rodriguez María Fernanda Yasnot-Acosta |
author_sort |
Catalina Tovar Acero |
title |
IL-4, IL-10, CCL2 and TGF-β as potential biomarkers for severity in Plasmodium vivax malaria. |
title_short |
IL-4, IL-10, CCL2 and TGF-β as potential biomarkers for severity in Plasmodium vivax malaria. |
title_full |
IL-4, IL-10, CCL2 and TGF-β as potential biomarkers for severity in Plasmodium vivax malaria. |
title_fullStr |
IL-4, IL-10, CCL2 and TGF-β as potential biomarkers for severity in Plasmodium vivax malaria. |
title_full_unstemmed |
IL-4, IL-10, CCL2 and TGF-β as potential biomarkers for severity in Plasmodium vivax malaria. |
title_sort |
il-4, il-10, ccl2 and tgf-β as potential biomarkers for severity in plasmodium vivax malaria. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2022 |
url |
https://doi.org/10.1371/journal.pntd.0010798 https://doaj.org/article/28bb6c3106e04ebc9c3e3fbf5cc692a2 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 16, Iss 9, p e0010798 (2022) |
op_relation |
https://doi.org/10.1371/journal.pntd.0010798 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0010798 https://doaj.org/article/28bb6c3106e04ebc9c3e3fbf5cc692a2 |
op_doi |
https://doi.org/10.1371/journal.pntd.0010798 |
container_title |
PLOS Neglected Tropical Diseases |
container_volume |
16 |
container_issue |
9 |
container_start_page |
e0010798 |
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