Protective effect of ashwagandha (Withania somnifera) against neurotoxicity induced by aluminum chloride in rats
Objective: To evaluate the neuroprotective effect of ashwagandha extract against aluminum chloride-induced neurotoxicity in rats. Methods: Rats were divided into control, aluminum-intoxicated rats treated daily with aluminum trichloride (AlCl3) (100 mg/kg, orally) for 30 d and aluminum-intoxicated a...
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Wolters Kluwer Medknow Publications
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ftdoajarticles:oai:doaj.org/article:289d51e969294267aed29968755bbd60 2023-05-15T15:10:59+02:00 Protective effect of ashwagandha (Withania somnifera) against neurotoxicity induced by aluminum chloride in rats Mohamed E Elhadidy Hussein G Sawie Nagwa A Meguid Yasser A Khadrawy 2018-01-01T00:00:00Z https://doi.org/10.4103/2221-1691.221139 https://doaj.org/article/289d51e969294267aed29968755bbd60 EN eng Wolters Kluwer Medknow Publications http://www.apjtb.org/article.asp?issn=2221-1691;year=2018;volume=8;issue=1;spage=59;epage=66;aulast=Elhadidy https://doaj.org/toc/2221-1691 2221-1691 doi:10.4103/2221-1691.221139 https://doaj.org/article/289d51e969294267aed29968755bbd60 Asian Pacific Journal of Tropical Biomedicine, Vol 8, Iss 1, Pp 59-66 (2018) ashwagandha neurotoxicity oxidative stress tnf-α acetylcholinesterase na+/k+-atpase Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 article 2018 ftdoajarticles https://doi.org/10.4103/2221-1691.221139 2022-12-31T09:09:04Z Objective: To evaluate the neuroprotective effect of ashwagandha extract against aluminum chloride-induced neurotoxicity in rats. Methods: Rats were divided into control, aluminum-intoxicated rats treated daily with aluminum trichloride (AlCl3) (100 mg/kg, orally) for 30 d and aluminum-intoxicated animals protected by receiving daily ashwagandha extract (200 mg/kg, orally) one hour before AlCl3 administration for 30 d. Levels of lipid peroxidation, nitric oxide, reduced glutathione and tumor necrosis factor-α were measured in the cortex, hippocampus and striatum. In addition, the activities of Na+, K+, ATPase and acetylcholinesterase were determined in the three studied brain regions. Results: Aluminum increased the levels of lipid peroxidation and nitric oxide in the cortex, hippocampus and striatum and decreased the reduced glutathione level in the hippocampus and striatum. In rats protected with ashwagandha extract, non significant changes were observed in lipid peroxidation, nitric oxide and reduced glutathione. In addition, ashwagandha extracts prevented the increased activity of acetylcholinesterase and Na+, K+, ATPase induced by AlCl3 in the cortex, hippocampus and striatum. The present findings also showed that the significant increase in tumor necrosis factor-α induced by AlCl3 in the cortex and hippocampus was prevented by ashwagandha extract. Conclusions: The present results suggest that ashwagandha extract possesses antioxidant and anti-inflammatory effects against aluminum neurotoxicity. In addition, ashwagandha extract could prevent the decline in cholinergic activity by maintaining normal acetylcholinesterase activity. The later effect could recommend the use of ashwagandha as a memory enhancer. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Asian Pacific Journal of Tropical Biomedicine 8 1 59 |
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Directory of Open Access Journals: DOAJ Articles |
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language |
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ashwagandha neurotoxicity oxidative stress tnf-α acetylcholinesterase na+/k+-atpase Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
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ashwagandha neurotoxicity oxidative stress tnf-α acetylcholinesterase na+/k+-atpase Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 Mohamed E Elhadidy Hussein G Sawie Nagwa A Meguid Yasser A Khadrawy Protective effect of ashwagandha (Withania somnifera) against neurotoxicity induced by aluminum chloride in rats |
topic_facet |
ashwagandha neurotoxicity oxidative stress tnf-α acetylcholinesterase na+/k+-atpase Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
description |
Objective: To evaluate the neuroprotective effect of ashwagandha extract against aluminum chloride-induced neurotoxicity in rats. Methods: Rats were divided into control, aluminum-intoxicated rats treated daily with aluminum trichloride (AlCl3) (100 mg/kg, orally) for 30 d and aluminum-intoxicated animals protected by receiving daily ashwagandha extract (200 mg/kg, orally) one hour before AlCl3 administration for 30 d. Levels of lipid peroxidation, nitric oxide, reduced glutathione and tumor necrosis factor-α were measured in the cortex, hippocampus and striatum. In addition, the activities of Na+, K+, ATPase and acetylcholinesterase were determined in the three studied brain regions. Results: Aluminum increased the levels of lipid peroxidation and nitric oxide in the cortex, hippocampus and striatum and decreased the reduced glutathione level in the hippocampus and striatum. In rats protected with ashwagandha extract, non significant changes were observed in lipid peroxidation, nitric oxide and reduced glutathione. In addition, ashwagandha extracts prevented the increased activity of acetylcholinesterase and Na+, K+, ATPase induced by AlCl3 in the cortex, hippocampus and striatum. The present findings also showed that the significant increase in tumor necrosis factor-α induced by AlCl3 in the cortex and hippocampus was prevented by ashwagandha extract. Conclusions: The present results suggest that ashwagandha extract possesses antioxidant and anti-inflammatory effects against aluminum neurotoxicity. In addition, ashwagandha extract could prevent the decline in cholinergic activity by maintaining normal acetylcholinesterase activity. The later effect could recommend the use of ashwagandha as a memory enhancer. |
format |
Article in Journal/Newspaper |
author |
Mohamed E Elhadidy Hussein G Sawie Nagwa A Meguid Yasser A Khadrawy |
author_facet |
Mohamed E Elhadidy Hussein G Sawie Nagwa A Meguid Yasser A Khadrawy |
author_sort |
Mohamed E Elhadidy |
title |
Protective effect of ashwagandha (Withania somnifera) against neurotoxicity induced by aluminum chloride in rats |
title_short |
Protective effect of ashwagandha (Withania somnifera) against neurotoxicity induced by aluminum chloride in rats |
title_full |
Protective effect of ashwagandha (Withania somnifera) against neurotoxicity induced by aluminum chloride in rats |
title_fullStr |
Protective effect of ashwagandha (Withania somnifera) against neurotoxicity induced by aluminum chloride in rats |
title_full_unstemmed |
Protective effect of ashwagandha (Withania somnifera) against neurotoxicity induced by aluminum chloride in rats |
title_sort |
protective effect of ashwagandha (withania somnifera) against neurotoxicity induced by aluminum chloride in rats |
publisher |
Wolters Kluwer Medknow Publications |
publishDate |
2018 |
url |
https://doi.org/10.4103/2221-1691.221139 https://doaj.org/article/289d51e969294267aed29968755bbd60 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Asian Pacific Journal of Tropical Biomedicine, Vol 8, Iss 1, Pp 59-66 (2018) |
op_relation |
http://www.apjtb.org/article.asp?issn=2221-1691;year=2018;volume=8;issue=1;spage=59;epage=66;aulast=Elhadidy https://doaj.org/toc/2221-1691 2221-1691 doi:10.4103/2221-1691.221139 https://doaj.org/article/289d51e969294267aed29968755bbd60 |
op_doi |
https://doi.org/10.4103/2221-1691.221139 |
container_title |
Asian Pacific Journal of Tropical Biomedicine |
container_volume |
8 |
container_issue |
1 |
container_start_page |
59 |
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1766341905575051264 |