A research agenda for helminth diseases of humans: the problem of helminthiases.
A disproportionate burden of helminthiases in human populations occurs in marginalised, low-income, and resource-constrained regions of the world, with over 1 billion people in developing areas of sub-Saharan Africa, Asia, and the Americas infected with one or more helminth species. The morbidity ca...
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ftdoajarticles:oai:doaj.org/article:28968a02669c499caf20fa77771c6690 2023-05-15T15:13:18+02:00 A research agenda for helminth diseases of humans: the problem of helminthiases. Sara Lustigman Roger K Prichard Andrea Gazzinelli Warwick N Grant Boakye A Boatin James S McCarthy María-Gloria Basáñez 2012-01-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0001582 https://doaj.org/article/28968a02669c499caf20fa77771c6690 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC3335854?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0001582 https://doaj.org/article/28968a02669c499caf20fa77771c6690 PLoS Neglected Tropical Diseases, Vol 6, Iss 4, p e1582 (2012) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2012 ftdoajarticles https://doi.org/10.1371/journal.pntd.0001582 2022-12-31T14:20:30Z A disproportionate burden of helminthiases in human populations occurs in marginalised, low-income, and resource-constrained regions of the world, with over 1 billion people in developing areas of sub-Saharan Africa, Asia, and the Americas infected with one or more helminth species. The morbidity caused by such infections imposes a substantial burden of disease, contributing to a vicious circle of infection, poverty, decreased productivity, and inadequate socioeconomic development. Furthermore, helminth infection accentuates the morbidity of malaria and HIV/AIDS, and impairs vaccine efficacy. Polyparasitism is the norm in these populations, and infections tend to be persistent. Hence, there is a great need to reduce morbidity caused by helminth infections. However, major deficiencies exist in diagnostics and interventions, including vector control, drugs, and vaccines. Overcoming these deficiencies is hampered by major gaps in knowledge of helminth biology and transmission dynamics, platforms from which to help develop such tools. The Disease Reference Group on Helminths Infections (DRG4), established in 2009 by the Special Programme for Research and Training in Tropical Diseases (TDR), was given the mandate to review helminthiases research and identify research priorities and gaps. In this review, we provide an overview of the forces driving the persistence of helminthiases as a public health problem despite the many control initiatives that have been put in place; identify the main obstacles that impede progress towards their control and elimination; and discuss recent advances, opportunities, and challenges for the understanding of the biology, epidemiology, and control of these infections. The helminth infections that will be discussed include: onchocerciasis, lymphatic filariasis, soil-transmitted helminthiases, schistosomiasis, food-borne trematodiases, and taeniasis/cysticercosis. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLoS Neglected Tropical Diseases 6 4 e1582 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Sara Lustigman Roger K Prichard Andrea Gazzinelli Warwick N Grant Boakye A Boatin James S McCarthy María-Gloria Basáñez A research agenda for helminth diseases of humans: the problem of helminthiases. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
A disproportionate burden of helminthiases in human populations occurs in marginalised, low-income, and resource-constrained regions of the world, with over 1 billion people in developing areas of sub-Saharan Africa, Asia, and the Americas infected with one or more helminth species. The morbidity caused by such infections imposes a substantial burden of disease, contributing to a vicious circle of infection, poverty, decreased productivity, and inadequate socioeconomic development. Furthermore, helminth infection accentuates the morbidity of malaria and HIV/AIDS, and impairs vaccine efficacy. Polyparasitism is the norm in these populations, and infections tend to be persistent. Hence, there is a great need to reduce morbidity caused by helminth infections. However, major deficiencies exist in diagnostics and interventions, including vector control, drugs, and vaccines. Overcoming these deficiencies is hampered by major gaps in knowledge of helminth biology and transmission dynamics, platforms from which to help develop such tools. The Disease Reference Group on Helminths Infections (DRG4), established in 2009 by the Special Programme for Research and Training in Tropical Diseases (TDR), was given the mandate to review helminthiases research and identify research priorities and gaps. In this review, we provide an overview of the forces driving the persistence of helminthiases as a public health problem despite the many control initiatives that have been put in place; identify the main obstacles that impede progress towards their control and elimination; and discuss recent advances, opportunities, and challenges for the understanding of the biology, epidemiology, and control of these infections. The helminth infections that will be discussed include: onchocerciasis, lymphatic filariasis, soil-transmitted helminthiases, schistosomiasis, food-borne trematodiases, and taeniasis/cysticercosis. |
format |
Article in Journal/Newspaper |
author |
Sara Lustigman Roger K Prichard Andrea Gazzinelli Warwick N Grant Boakye A Boatin James S McCarthy María-Gloria Basáñez |
author_facet |
Sara Lustigman Roger K Prichard Andrea Gazzinelli Warwick N Grant Boakye A Boatin James S McCarthy María-Gloria Basáñez |
author_sort |
Sara Lustigman |
title |
A research agenda for helminth diseases of humans: the problem of helminthiases. |
title_short |
A research agenda for helminth diseases of humans: the problem of helminthiases. |
title_full |
A research agenda for helminth diseases of humans: the problem of helminthiases. |
title_fullStr |
A research agenda for helminth diseases of humans: the problem of helminthiases. |
title_full_unstemmed |
A research agenda for helminth diseases of humans: the problem of helminthiases. |
title_sort |
research agenda for helminth diseases of humans: the problem of helminthiases. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2012 |
url |
https://doi.org/10.1371/journal.pntd.0001582 https://doaj.org/article/28968a02669c499caf20fa77771c6690 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 6, Iss 4, p e1582 (2012) |
op_relation |
http://europepmc.org/articles/PMC3335854?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0001582 https://doaj.org/article/28968a02669c499caf20fa77771c6690 |
op_doi |
https://doi.org/10.1371/journal.pntd.0001582 |
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PLoS Neglected Tropical Diseases |
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6 |
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4 |
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e1582 |
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