Molecular and clinical epidemiological surveillance of dengue virus in Paraíba, Northeast Brazil
ABSTRACT INTRODUCTION: Despite being the most prevalent arboviral disease worldwide, dengue has been neglected lately. However, recent epidemics of arboviruses such as Zika and chikungunya in locations throughout the world have alerted health authorities to these diseases. This study evaluated the i...
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ftdoajarticles:oai:doaj.org/article:288d89d304ff47448d414e092b893ad7 2023-05-15T15:10:46+02:00 Molecular and clinical epidemiological surveillance of dengue virus in Paraíba, Northeast Brazil Isabel Cristina Guerra-Gomes Bruna Macêdo Gois Rephany Fonseca Peixoto Camila Alves Oliveira Bruna Leal Lima Maciel Maria Izabel Ferreira Sarmento Anna Stella Cysneiros Pachá Josélio Maria Galvão Araújo Ian Porto Gurgel Amaral Tatjana Souza Lima Keesen https://doi.org/10.1590/0037-8682-0419-2016 https://doaj.org/article/288d89d304ff47448d414e092b893ad7 EN eng Sociedade Brasileira de Medicina Tropical (SBMT) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822017000100019&lng=en&tlng=en https://doaj.org/toc/1678-9849 1678-9849 doi:10.1590/0037-8682-0419-2016 https://doaj.org/article/288d89d304ff47448d414e092b893ad7 Revista da Sociedade Brasileira de Medicina Tropical, Vol 50, Iss 1, Pp 19-26 DENV serotypes Molecular epidemiology Arboviruses Arctic medicine. Tropical medicine RC955-962 article ftdoajarticles https://doi.org/10.1590/0037-8682-0419-2016 2022-12-30T21:42:26Z ABSTRACT INTRODUCTION: Despite being the most prevalent arboviral disease worldwide, dengue has been neglected lately. However, recent epidemics of arboviruses such as Zika and chikungunya in locations throughout the world have alerted health authorities to these diseases. This study evaluated the incidence pattern of dengue, its clinical characteristics, and co-circulation of serotypes from 2007 to 2015 in Paraiba State, Northeast Brazil. METHODS: Data on dengue cases from 2007 to 2015 were extracted from clinical reports of the National System for Notifiable Diseases [Sistema Nacional de Agravos de Notificação (SINAN)] of Brazil provided by the Paraiba Health Department. Reverse transcription polymerase chain reaction (RT-PCR) assays for dengue serotypes were carried out on plasma samples obtained from patients with suspected dengue. The data were analysed using descriptive statistics. RESULTS: According to clinical features, dengue fever [n = 39,083 (70.2%)] and dengue without warning signs [n = 15,365 (27.7%)] were the most common classifications of dengue. On RT-PCR, DENV 1 was the most commonly identified serotype (80.5%) in all years studied. Co-circulation of all four DENV serotypes was observed in 2013 and 2014. Furthermore, we observed an increase in dengue notifications in 2015, possibly due to the rise of Zika and chikungunya. CONCLUSIONS: Our findings support the hypothesis that co-circulation of the four DENV serotypes may be a reason for the increased prevalence of severe forms of dengue in the years studied. This study may contribute to directing research, health policy, and financial resources toward reducing poorly controlled epidemic diseases. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Revista da Sociedade Brasileira de Medicina Tropical 50 1 19 26 |
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Directory of Open Access Journals: DOAJ Articles |
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DENV serotypes Molecular epidemiology Arboviruses Arctic medicine. Tropical medicine RC955-962 |
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DENV serotypes Molecular epidemiology Arboviruses Arctic medicine. Tropical medicine RC955-962 Isabel Cristina Guerra-Gomes Bruna Macêdo Gois Rephany Fonseca Peixoto Camila Alves Oliveira Bruna Leal Lima Maciel Maria Izabel Ferreira Sarmento Anna Stella Cysneiros Pachá Josélio Maria Galvão Araújo Ian Porto Gurgel Amaral Tatjana Souza Lima Keesen Molecular and clinical epidemiological surveillance of dengue virus in Paraíba, Northeast Brazil |
topic_facet |
DENV serotypes Molecular epidemiology Arboviruses Arctic medicine. Tropical medicine RC955-962 |
description |
ABSTRACT INTRODUCTION: Despite being the most prevalent arboviral disease worldwide, dengue has been neglected lately. However, recent epidemics of arboviruses such as Zika and chikungunya in locations throughout the world have alerted health authorities to these diseases. This study evaluated the incidence pattern of dengue, its clinical characteristics, and co-circulation of serotypes from 2007 to 2015 in Paraiba State, Northeast Brazil. METHODS: Data on dengue cases from 2007 to 2015 were extracted from clinical reports of the National System for Notifiable Diseases [Sistema Nacional de Agravos de Notificação (SINAN)] of Brazil provided by the Paraiba Health Department. Reverse transcription polymerase chain reaction (RT-PCR) assays for dengue serotypes were carried out on plasma samples obtained from patients with suspected dengue. The data were analysed using descriptive statistics. RESULTS: According to clinical features, dengue fever [n = 39,083 (70.2%)] and dengue without warning signs [n = 15,365 (27.7%)] were the most common classifications of dengue. On RT-PCR, DENV 1 was the most commonly identified serotype (80.5%) in all years studied. Co-circulation of all four DENV serotypes was observed in 2013 and 2014. Furthermore, we observed an increase in dengue notifications in 2015, possibly due to the rise of Zika and chikungunya. CONCLUSIONS: Our findings support the hypothesis that co-circulation of the four DENV serotypes may be a reason for the increased prevalence of severe forms of dengue in the years studied. This study may contribute to directing research, health policy, and financial resources toward reducing poorly controlled epidemic diseases. |
format |
Article in Journal/Newspaper |
author |
Isabel Cristina Guerra-Gomes Bruna Macêdo Gois Rephany Fonseca Peixoto Camila Alves Oliveira Bruna Leal Lima Maciel Maria Izabel Ferreira Sarmento Anna Stella Cysneiros Pachá Josélio Maria Galvão Araújo Ian Porto Gurgel Amaral Tatjana Souza Lima Keesen |
author_facet |
Isabel Cristina Guerra-Gomes Bruna Macêdo Gois Rephany Fonseca Peixoto Camila Alves Oliveira Bruna Leal Lima Maciel Maria Izabel Ferreira Sarmento Anna Stella Cysneiros Pachá Josélio Maria Galvão Araújo Ian Porto Gurgel Amaral Tatjana Souza Lima Keesen |
author_sort |
Isabel Cristina Guerra-Gomes |
title |
Molecular and clinical epidemiological surveillance of dengue virus in Paraíba, Northeast Brazil |
title_short |
Molecular and clinical epidemiological surveillance of dengue virus in Paraíba, Northeast Brazil |
title_full |
Molecular and clinical epidemiological surveillance of dengue virus in Paraíba, Northeast Brazil |
title_fullStr |
Molecular and clinical epidemiological surveillance of dengue virus in Paraíba, Northeast Brazil |
title_full_unstemmed |
Molecular and clinical epidemiological surveillance of dengue virus in Paraíba, Northeast Brazil |
title_sort |
molecular and clinical epidemiological surveillance of dengue virus in paraíba, northeast brazil |
publisher |
Sociedade Brasileira de Medicina Tropical (SBMT) |
url |
https://doi.org/10.1590/0037-8682-0419-2016 https://doaj.org/article/288d89d304ff47448d414e092b893ad7 |
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Arctic |
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Arctic |
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Arctic |
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Arctic |
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Revista da Sociedade Brasileira de Medicina Tropical, Vol 50, Iss 1, Pp 19-26 |
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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822017000100019&lng=en&tlng=en https://doaj.org/toc/1678-9849 1678-9849 doi:10.1590/0037-8682-0419-2016 https://doaj.org/article/288d89d304ff47448d414e092b893ad7 |
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https://doi.org/10.1590/0037-8682-0419-2016 |
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Revista da Sociedade Brasileira de Medicina Tropical |
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