Screening of selected ethnomedicinal plants from South Africa for larvicidal activity against the mosquito Anopheles arabiensis
Abstract Background This study was initiated to establish whether any South African ethnomedicinal plants (indigenous or exotic), that have been reported to be used traditionally to repel or kill mosquitoes, exhibit effective mosquito larvicidal properties. Methods Extracts of a selection of plant t...
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ftdoajarticles:oai:doaj.org/article:2877c8f3230e4d23ae17eb72dca5bfac 2023-05-15T15:08:49+02:00 Screening of selected ethnomedicinal plants from South Africa for larvicidal activity against the mosquito Anopheles arabiensis Maharaj Rajendra Maharaj Vinesh Crouch Neil R Bhagwandin Niresh Folb Peter I Pillay Pamisha Gayaram Reshma 2012-09-01T00:00:00Z https://doi.org/10.1186/1475-2875-11-320 https://doaj.org/article/2877c8f3230e4d23ae17eb72dca5bfac EN eng BMC http://www.malariajournal.com/content/11/1/320 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-11-320 1475-2875 https://doaj.org/article/2877c8f3230e4d23ae17eb72dca5bfac Malaria Journal, Vol 11, Iss 1, p 320 (2012) Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2012 ftdoajarticles https://doi.org/10.1186/1475-2875-11-320 2022-12-31T01:15:27Z Abstract Background This study was initiated to establish whether any South African ethnomedicinal plants (indigenous or exotic), that have been reported to be used traditionally to repel or kill mosquitoes, exhibit effective mosquito larvicidal properties. Methods Extracts of a selection of plant taxa sourced in South Africa were tested for larvicidal properties in an applicable assay. Thirty 3 rd instar Anopheles arabiensis larvae were exposed to various extract types (dichloromethane, dichloromethane/methanol) (1:1), methanol and purified water) of each species investigated. Mortality was evaluated relative to the positive control Temephos (Mostop; Agrivo), an effective emulsifiable concentrate larvicide. Results Preliminary screening of crude extracts revealed substantial variation in toxicity with 24 of the 381 samples displaying 100% larval mortality within the seven day exposure period. Four of the high activity plants were selected and subjected to bioassay guided fractionation. The results of the testing of the fractions generated identified one fraction of the plant, Toddalia asiatica as being very potent against the An. arabiensis larvae. Conclusion The present study has successfully identified a plant with superior larvicidal activity at both the crude and semi pure fractions generated through bio-assay guided fractionation. These results have initiated further research into isolating the active compound and developing a malaria vector control tool. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 11 1 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
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English |
topic |
Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
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Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Maharaj Rajendra Maharaj Vinesh Crouch Neil R Bhagwandin Niresh Folb Peter I Pillay Pamisha Gayaram Reshma Screening of selected ethnomedicinal plants from South Africa for larvicidal activity against the mosquito Anopheles arabiensis |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background This study was initiated to establish whether any South African ethnomedicinal plants (indigenous or exotic), that have been reported to be used traditionally to repel or kill mosquitoes, exhibit effective mosquito larvicidal properties. Methods Extracts of a selection of plant taxa sourced in South Africa were tested for larvicidal properties in an applicable assay. Thirty 3 rd instar Anopheles arabiensis larvae were exposed to various extract types (dichloromethane, dichloromethane/methanol) (1:1), methanol and purified water) of each species investigated. Mortality was evaluated relative to the positive control Temephos (Mostop; Agrivo), an effective emulsifiable concentrate larvicide. Results Preliminary screening of crude extracts revealed substantial variation in toxicity with 24 of the 381 samples displaying 100% larval mortality within the seven day exposure period. Four of the high activity plants were selected and subjected to bioassay guided fractionation. The results of the testing of the fractions generated identified one fraction of the plant, Toddalia asiatica as being very potent against the An. arabiensis larvae. Conclusion The present study has successfully identified a plant with superior larvicidal activity at both the crude and semi pure fractions generated through bio-assay guided fractionation. These results have initiated further research into isolating the active compound and developing a malaria vector control tool. |
format |
Article in Journal/Newspaper |
author |
Maharaj Rajendra Maharaj Vinesh Crouch Neil R Bhagwandin Niresh Folb Peter I Pillay Pamisha Gayaram Reshma |
author_facet |
Maharaj Rajendra Maharaj Vinesh Crouch Neil R Bhagwandin Niresh Folb Peter I Pillay Pamisha Gayaram Reshma |
author_sort |
Maharaj Rajendra |
title |
Screening of selected ethnomedicinal plants from South Africa for larvicidal activity against the mosquito Anopheles arabiensis |
title_short |
Screening of selected ethnomedicinal plants from South Africa for larvicidal activity against the mosquito Anopheles arabiensis |
title_full |
Screening of selected ethnomedicinal plants from South Africa for larvicidal activity against the mosquito Anopheles arabiensis |
title_fullStr |
Screening of selected ethnomedicinal plants from South Africa for larvicidal activity against the mosquito Anopheles arabiensis |
title_full_unstemmed |
Screening of selected ethnomedicinal plants from South Africa for larvicidal activity against the mosquito Anopheles arabiensis |
title_sort |
screening of selected ethnomedicinal plants from south africa for larvicidal activity against the mosquito anopheles arabiensis |
publisher |
BMC |
publishDate |
2012 |
url |
https://doi.org/10.1186/1475-2875-11-320 https://doaj.org/article/2877c8f3230e4d23ae17eb72dca5bfac |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 11, Iss 1, p 320 (2012) |
op_relation |
http://www.malariajournal.com/content/11/1/320 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-11-320 1475-2875 https://doaj.org/article/2877c8f3230e4d23ae17eb72dca5bfac |
op_doi |
https://doi.org/10.1186/1475-2875-11-320 |
container_title |
Malaria Journal |
container_volume |
11 |
container_issue |
1 |
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1766340099598974976 |