Genetic variation in the immune system and malaria susceptibility in infants: a nested case–control study in Nanoro, Burkina Faso
Abstract Background Genetic polymorphisms in the human immune system modulate susceptibility to malaria. However, there is a paucity of data on the contribution of immunogenetic variants to malaria susceptibility in infants, who present differential biological features related to the immaturity of t...
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ftdoajarticles:oai:doaj.org/article:28641e0d45224781aa5692bfdde868b9 2023-05-15T15:15:43+02:00 Genetic variation in the immune system and malaria susceptibility in infants: a nested case–control study in Nanoro, Burkina Faso Hamatandi Magloire Natama Eduard Rovira-Vallbona Meryam Krit Pieter Guetens Hermann Sorgho M. Athanase Somé Maminata Traoré-Coulibaly Innocent Valéa Petra F. Mens Henk D. F. H. Schallig Dirk Berkvens Luc Kestens Halidou Tinto Anna Rosanas-Urgell 2021-02-01T00:00:00Z https://doi.org/10.1186/s12936-021-03628-y https://doaj.org/article/28641e0d45224781aa5692bfdde868b9 EN eng BMC https://doi.org/10.1186/s12936-021-03628-y https://doaj.org/toc/1475-2875 doi:10.1186/s12936-021-03628-y 1475-2875 https://doaj.org/article/28641e0d45224781aa5692bfdde868b9 Malaria Journal, Vol 20, Iss 1, Pp 1-14 (2021) Malaria Plasmodium falciparum Immunogenetic variants Cytokines Innate immunity Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2021 ftdoajarticles https://doi.org/10.1186/s12936-021-03628-y 2022-12-31T10:26:38Z Abstract Background Genetic polymorphisms in the human immune system modulate susceptibility to malaria. However, there is a paucity of data on the contribution of immunogenetic variants to malaria susceptibility in infants, who present differential biological features related to the immaturity of their adaptive immune system, the protective effect of maternal antibodies and fetal haemoglobin. This study investigated the association between genetic variation in innate immune response genes and malaria susceptibility during the first year of life in 656 infants from a birth cohort survey performed in Nanoro, Burkina Faso. Methods Seventeen single nucleotide polymorphisms (SNPs) in 11 genes of the immune system previously associated with different malaria phenotypes were genotyped using TaqMan allelic hybridization assays in a Fluidigm platform. Plasmodium falciparum infection and clinical disease were documented by active and passive case detection. Case–control association analyses for both alleles and genotypes were carried out using univariate and multivariate logistic regression. For cytokines showing significant SNP associations in multivariate analyses, cord blood supernatant concentrations were measured by quantitative suspension array technology (Luminex). Results Genetic variants in IL-1β (rs1143634) and FcγRIIA/CD32 (rs1801274)—both in allelic, dominant and co-dominant models—were significantly associated with protection from both P. falciparum infection and clinical malaria. Furthermore, heterozygote individuals with rs1801274 SNP in FcγRIIA/CD32 showed higher IL-1RA levels compared to wild-type homozygotes (P = 0.024), a cytokine whose production is promoted by the binding of IgG immune complexes to Fcγ receptors on effector immune cells. Conclusions These findings indicate that genetic polymorphisms in genes driving innate immune responses are associated to malaria susceptibility during the first year of life, possibly by modulating production of inflammatory mediators. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 20 1 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
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English |
topic |
Malaria Plasmodium falciparum Immunogenetic variants Cytokines Innate immunity Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
Malaria Plasmodium falciparum Immunogenetic variants Cytokines Innate immunity Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Hamatandi Magloire Natama Eduard Rovira-Vallbona Meryam Krit Pieter Guetens Hermann Sorgho M. Athanase Somé Maminata Traoré-Coulibaly Innocent Valéa Petra F. Mens Henk D. F. H. Schallig Dirk Berkvens Luc Kestens Halidou Tinto Anna Rosanas-Urgell Genetic variation in the immune system and malaria susceptibility in infants: a nested case–control study in Nanoro, Burkina Faso |
topic_facet |
Malaria Plasmodium falciparum Immunogenetic variants Cytokines Innate immunity Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background Genetic polymorphisms in the human immune system modulate susceptibility to malaria. However, there is a paucity of data on the contribution of immunogenetic variants to malaria susceptibility in infants, who present differential biological features related to the immaturity of their adaptive immune system, the protective effect of maternal antibodies and fetal haemoglobin. This study investigated the association between genetic variation in innate immune response genes and malaria susceptibility during the first year of life in 656 infants from a birth cohort survey performed in Nanoro, Burkina Faso. Methods Seventeen single nucleotide polymorphisms (SNPs) in 11 genes of the immune system previously associated with different malaria phenotypes were genotyped using TaqMan allelic hybridization assays in a Fluidigm platform. Plasmodium falciparum infection and clinical disease were documented by active and passive case detection. Case–control association analyses for both alleles and genotypes were carried out using univariate and multivariate logistic regression. For cytokines showing significant SNP associations in multivariate analyses, cord blood supernatant concentrations were measured by quantitative suspension array technology (Luminex). Results Genetic variants in IL-1β (rs1143634) and FcγRIIA/CD32 (rs1801274)—both in allelic, dominant and co-dominant models—were significantly associated with protection from both P. falciparum infection and clinical malaria. Furthermore, heterozygote individuals with rs1801274 SNP in FcγRIIA/CD32 showed higher IL-1RA levels compared to wild-type homozygotes (P = 0.024), a cytokine whose production is promoted by the binding of IgG immune complexes to Fcγ receptors on effector immune cells. Conclusions These findings indicate that genetic polymorphisms in genes driving innate immune responses are associated to malaria susceptibility during the first year of life, possibly by modulating production of inflammatory mediators. |
format |
Article in Journal/Newspaper |
author |
Hamatandi Magloire Natama Eduard Rovira-Vallbona Meryam Krit Pieter Guetens Hermann Sorgho M. Athanase Somé Maminata Traoré-Coulibaly Innocent Valéa Petra F. Mens Henk D. F. H. Schallig Dirk Berkvens Luc Kestens Halidou Tinto Anna Rosanas-Urgell |
author_facet |
Hamatandi Magloire Natama Eduard Rovira-Vallbona Meryam Krit Pieter Guetens Hermann Sorgho M. Athanase Somé Maminata Traoré-Coulibaly Innocent Valéa Petra F. Mens Henk D. F. H. Schallig Dirk Berkvens Luc Kestens Halidou Tinto Anna Rosanas-Urgell |
author_sort |
Hamatandi Magloire Natama |
title |
Genetic variation in the immune system and malaria susceptibility in infants: a nested case–control study in Nanoro, Burkina Faso |
title_short |
Genetic variation in the immune system and malaria susceptibility in infants: a nested case–control study in Nanoro, Burkina Faso |
title_full |
Genetic variation in the immune system and malaria susceptibility in infants: a nested case–control study in Nanoro, Burkina Faso |
title_fullStr |
Genetic variation in the immune system and malaria susceptibility in infants: a nested case–control study in Nanoro, Burkina Faso |
title_full_unstemmed |
Genetic variation in the immune system and malaria susceptibility in infants: a nested case–control study in Nanoro, Burkina Faso |
title_sort |
genetic variation in the immune system and malaria susceptibility in infants: a nested case–control study in nanoro, burkina faso |
publisher |
BMC |
publishDate |
2021 |
url |
https://doi.org/10.1186/s12936-021-03628-y https://doaj.org/article/28641e0d45224781aa5692bfdde868b9 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 20, Iss 1, Pp 1-14 (2021) |
op_relation |
https://doi.org/10.1186/s12936-021-03628-y https://doaj.org/toc/1475-2875 doi:10.1186/s12936-021-03628-y 1475-2875 https://doaj.org/article/28641e0d45224781aa5692bfdde868b9 |
op_doi |
https://doi.org/10.1186/s12936-021-03628-y |
container_title |
Malaria Journal |
container_volume |
20 |
container_issue |
1 |
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1766346069996732416 |