RESISTANCE TO OXAMNIQUINE OF A Schistosoma mansoni STRAIN ISOLATED FROM PATIENT SUBMITTED TO REPEATED TREATMENTS
A strain of Schistosoma mansoni (R1) was isolated from patient previously submitted to four treatments with oxamniquine, and to another one with praziquantel. The results obtained with chemotherapeutic test, by using oxamniquine in mice infected with the strains R1 and LE (standard), showed an evide...
Published in: | Revista do Instituto de Medicina Tropical de São Paulo |
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Language: | English |
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Universidade de São Paulo (USP)
1997
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ftdoajarticles:oai:doaj.org/article:2858117099a74ac1a8229bd9902c87d1 2024-09-09T19:28:39+00:00 RESISTANCE TO OXAMNIQUINE OF A Schistosoma mansoni STRAIN ISOLATED FROM PATIENT SUBMITTED TO REPEATED TREATMENTS M.Z. COELHO F.C. LIMA E SILVA J.A. NOGUEIRA-MACHADO 1997-03-01T00:00:00Z https://doi.org/10.1590/S0036-46651997000200007 https://doaj.org/article/2858117099a74ac1a8229bd9902c87d1 EN eng Universidade de São Paulo (USP) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46651997000200007 https://doaj.org/toc/0036-4665 https://doaj.org/toc/1678-9946 doi:10.1590/S0036-46651997000200007 0036-4665 1678-9946 https://doaj.org/article/2858117099a74ac1a8229bd9902c87d1 Revista do Instituto de Medicina Tropical de São Paulo, Vol 39, Iss 2, p 101 (1997) Schistosoma mansoni drug resistance oxamniquine praziquantel Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 1997 ftdoajarticles https://doi.org/10.1590/S0036-46651997000200007 2024-08-05T17:49:30Z A strain of Schistosoma mansoni (R1) was isolated from patient previously submitted to four treatments with oxamniquine, and to another one with praziquantel. The results obtained with chemotherapeutic test, by using oxamniquine in mice infected with the strains R1 and LE (standard), showed an evident resistance to the drug in worms of the strain R1. Thus, at the dose of 250 mg/kg oxamniquine, all mice (17) infected with the LE strain did not show surviving worms, whereas 12 out of 17 mice infected with the R1 strain presented surviving worms. At the dose of 200 mg/kg, the LE strain showed recovery rates of 1.06% and 20.58%, whereas the R1 strain presented 18.57% and 61.14%, for male and female worms, respectively. At the dose of 100 mg/kg, the recovery of male worms was 2.6% for the LE strain, and 29.9% for the R1 strain. At the same dose, the recovery of females did not show statistically significant differences between the two strains (LE = 76.38%, R1 = 79.12%). Praziquantel showed similar antischistosomal activity against both studied strains, when administered at the dose of 500 mg/kg Resistência ao oxamniquine de uma cepa de Schistosoma mansoni isolada de paciente submetido a repetidos tratamentos Uma cepa de Schistosoma mansoni (R1) foi isolada de paciente previamente submetido a quatro tratamentos com oxamniquine e a um outro com praziquantel. Os resultados obtidos com o teste quimioterapêutico, usando oxamniquine em camundongos infectados com as cepas R1 e LE (padrão) mostraram resistência evidente à droga em vermes de cepa R1. Assim, com a dose de 250 mg/kg de oxamniquine, todos os camundongos (17) dos 17 camundongos infectados com a cepa R1 apresentaram vermes sobreviventes. Com a dosagem de 200 mg/kg a cepa LE mostrou taxas de recuperação de 1,06 e 20,58% enquanto a cepa R1 apresentou 18,57 e 61,14% para os vermes machos e fêmeas, respectivamente. Com a dose de 100 mg/kg a recuperação de vermes machos foi de 2,6% para a Cepa LE e 29,9% para a R1. Com a mesma dosagem, a recuperação de fêmeas não ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Droga ENVELOPE(6.521,6.521,62.644,62.644) Revista do Instituto de Medicina Tropical de São Paulo 39 2 101 106 |
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ftdoajarticles |
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English |
topic |
Schistosoma mansoni drug resistance oxamniquine praziquantel Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
Schistosoma mansoni drug resistance oxamniquine praziquantel Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 M.Z. COELHO F.C. LIMA E SILVA J.A. NOGUEIRA-MACHADO RESISTANCE TO OXAMNIQUINE OF A Schistosoma mansoni STRAIN ISOLATED FROM PATIENT SUBMITTED TO REPEATED TREATMENTS |
topic_facet |
Schistosoma mansoni drug resistance oxamniquine praziquantel Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
A strain of Schistosoma mansoni (R1) was isolated from patient previously submitted to four treatments with oxamniquine, and to another one with praziquantel. The results obtained with chemotherapeutic test, by using oxamniquine in mice infected with the strains R1 and LE (standard), showed an evident resistance to the drug in worms of the strain R1. Thus, at the dose of 250 mg/kg oxamniquine, all mice (17) infected with the LE strain did not show surviving worms, whereas 12 out of 17 mice infected with the R1 strain presented surviving worms. At the dose of 200 mg/kg, the LE strain showed recovery rates of 1.06% and 20.58%, whereas the R1 strain presented 18.57% and 61.14%, for male and female worms, respectively. At the dose of 100 mg/kg, the recovery of male worms was 2.6% for the LE strain, and 29.9% for the R1 strain. At the same dose, the recovery of females did not show statistically significant differences between the two strains (LE = 76.38%, R1 = 79.12%). Praziquantel showed similar antischistosomal activity against both studied strains, when administered at the dose of 500 mg/kg Resistência ao oxamniquine de uma cepa de Schistosoma mansoni isolada de paciente submetido a repetidos tratamentos Uma cepa de Schistosoma mansoni (R1) foi isolada de paciente previamente submetido a quatro tratamentos com oxamniquine e a um outro com praziquantel. Os resultados obtidos com o teste quimioterapêutico, usando oxamniquine em camundongos infectados com as cepas R1 e LE (padrão) mostraram resistência evidente à droga em vermes de cepa R1. Assim, com a dose de 250 mg/kg de oxamniquine, todos os camundongos (17) dos 17 camundongos infectados com a cepa R1 apresentaram vermes sobreviventes. Com a dosagem de 200 mg/kg a cepa LE mostrou taxas de recuperação de 1,06 e 20,58% enquanto a cepa R1 apresentou 18,57 e 61,14% para os vermes machos e fêmeas, respectivamente. Com a dose de 100 mg/kg a recuperação de vermes machos foi de 2,6% para a Cepa LE e 29,9% para a R1. Com a mesma dosagem, a recuperação de fêmeas não ... |
format |
Article in Journal/Newspaper |
author |
M.Z. COELHO F.C. LIMA E SILVA J.A. NOGUEIRA-MACHADO |
author_facet |
M.Z. COELHO F.C. LIMA E SILVA J.A. NOGUEIRA-MACHADO |
author_sort |
M.Z. COELHO |
title |
RESISTANCE TO OXAMNIQUINE OF A Schistosoma mansoni STRAIN ISOLATED FROM PATIENT SUBMITTED TO REPEATED TREATMENTS |
title_short |
RESISTANCE TO OXAMNIQUINE OF A Schistosoma mansoni STRAIN ISOLATED FROM PATIENT SUBMITTED TO REPEATED TREATMENTS |
title_full |
RESISTANCE TO OXAMNIQUINE OF A Schistosoma mansoni STRAIN ISOLATED FROM PATIENT SUBMITTED TO REPEATED TREATMENTS |
title_fullStr |
RESISTANCE TO OXAMNIQUINE OF A Schistosoma mansoni STRAIN ISOLATED FROM PATIENT SUBMITTED TO REPEATED TREATMENTS |
title_full_unstemmed |
RESISTANCE TO OXAMNIQUINE OF A Schistosoma mansoni STRAIN ISOLATED FROM PATIENT SUBMITTED TO REPEATED TREATMENTS |
title_sort |
resistance to oxamniquine of a schistosoma mansoni strain isolated from patient submitted to repeated treatments |
publisher |
Universidade de São Paulo (USP) |
publishDate |
1997 |
url |
https://doi.org/10.1590/S0036-46651997000200007 https://doaj.org/article/2858117099a74ac1a8229bd9902c87d1 |
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ENVELOPE(6.521,6.521,62.644,62.644) |
geographic |
Arctic Droga |
geographic_facet |
Arctic Droga |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista do Instituto de Medicina Tropical de São Paulo, Vol 39, Iss 2, p 101 (1997) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46651997000200007 https://doaj.org/toc/0036-4665 https://doaj.org/toc/1678-9946 doi:10.1590/S0036-46651997000200007 0036-4665 1678-9946 https://doaj.org/article/2858117099a74ac1a8229bd9902c87d1 |
op_doi |
https://doi.org/10.1590/S0036-46651997000200007 |
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Revista do Instituto de Medicina Tropical de São Paulo |
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39 |
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