Cytokine signatures of Plasmodium vivax infection during pregnancy and delivery outcomes.
Plasmodium vivax malaria is a neglected disease, particularly during pregnancy. Severe vivax malaria is associated with inflammatory responses but in pregnancy immune alterations make it uncertain as to what cytokine signatures predominate, and how the type and quantity of blood immune mediators inf...
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ftdoajarticles:oai:doaj.org/article:284c26da8cb944a28b3db6b84dfaef30 2023-05-15T15:14:30+02:00 Cytokine signatures of Plasmodium vivax infection during pregnancy and delivery outcomes. Carlota Dobaño Azucena Bardají Myriam Arévalo-Herrera Flor E Martínez-Espinosa Camila Bôtto-Menezes Norma Padilla Michela Menegon Swati Kochar Sanjay Kumar Kochar Holger Unger Maria Ome-Kaius Anna Rosanas-Urgell Adriana Malheiros Maria Eugenia Castellanos Dhiraj Hans Meghna Desai Aina Casellas Chetan E Chitnis Carlo Severini Ivo Mueller Stephen Rogerson Clara Menéndez Pilar Requena 2020-05-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0008155 https://doaj.org/article/284c26da8cb944a28b3db6b84dfaef30 EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0008155 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0008155 https://doaj.org/article/284c26da8cb944a28b3db6b84dfaef30 PLoS Neglected Tropical Diseases, Vol 14, Iss 5, p e0008155 (2020) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2020 ftdoajarticles https://doi.org/10.1371/journal.pntd.0008155 2022-12-31T11:56:32Z Plasmodium vivax malaria is a neglected disease, particularly during pregnancy. Severe vivax malaria is associated with inflammatory responses but in pregnancy immune alterations make it uncertain as to what cytokine signatures predominate, and how the type and quantity of blood immune mediators influence delivery outcomes. We measured the plasma concentrations of a set of thirty-one biomarkers, comprising cytokines, chemokines and growth factors, in 987 plasma samples from a cohort of 572 pregnant women from five malaria-endemic tropical countries and related these concentrations to delivery outcomes (birth weight and hemoglobin levels) and malaria infection. Samples were collected at recruitment (first antenatal visit) and at delivery (periphery, cord and placenta). At recruitment, we found that P. vivax-infected pregnant women had higher plasma concentrations of proinflammatory (IL-6, IL-1β, CCL4, CCL2, CXCL10) and TH1-related cytokines (mainly IL-12) than uninfected women. This biomarker signature was essentially lost at delivery and was not associated with birth weight nor hemoglobin levels. Antiinflammatory cytokines (IL-10) were positively associated with infection and poor delivery outcomes. CCL11 was the only biomarker to show a negative association with P. vivax infection and its concentration at recruitment was positively associated with hemoglobin levels at delivery. Birth weight was negatively associated with peripheral IL-4 levels at delivery. Our multi-biomarker multicenter study is the first comprehensive one to characterize the immunological signature of P. vivax infection in pregnancy thus far. In conclusion, data show that while TH1 and pro-inflammatory responses are dominant during P. vivax infection in pregnancy, antiinflammatory cytokines may compensate excessive inflammation avoiding poor delivery outcomes, and skewness toward a TH2 response may trigger worse delivery outcomes. CCL11, a chemokine largely neglected in the field of malaria, emerges as an important marker of exposure or ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 14 5 e0008155 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Carlota Dobaño Azucena Bardají Myriam Arévalo-Herrera Flor E Martínez-Espinosa Camila Bôtto-Menezes Norma Padilla Michela Menegon Swati Kochar Sanjay Kumar Kochar Holger Unger Maria Ome-Kaius Anna Rosanas-Urgell Adriana Malheiros Maria Eugenia Castellanos Dhiraj Hans Meghna Desai Aina Casellas Chetan E Chitnis Carlo Severini Ivo Mueller Stephen Rogerson Clara Menéndez Pilar Requena Cytokine signatures of Plasmodium vivax infection during pregnancy and delivery outcomes. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Plasmodium vivax malaria is a neglected disease, particularly during pregnancy. Severe vivax malaria is associated with inflammatory responses but in pregnancy immune alterations make it uncertain as to what cytokine signatures predominate, and how the type and quantity of blood immune mediators influence delivery outcomes. We measured the plasma concentrations of a set of thirty-one biomarkers, comprising cytokines, chemokines and growth factors, in 987 plasma samples from a cohort of 572 pregnant women from five malaria-endemic tropical countries and related these concentrations to delivery outcomes (birth weight and hemoglobin levels) and malaria infection. Samples were collected at recruitment (first antenatal visit) and at delivery (periphery, cord and placenta). At recruitment, we found that P. vivax-infected pregnant women had higher plasma concentrations of proinflammatory (IL-6, IL-1β, CCL4, CCL2, CXCL10) and TH1-related cytokines (mainly IL-12) than uninfected women. This biomarker signature was essentially lost at delivery and was not associated with birth weight nor hemoglobin levels. Antiinflammatory cytokines (IL-10) were positively associated with infection and poor delivery outcomes. CCL11 was the only biomarker to show a negative association with P. vivax infection and its concentration at recruitment was positively associated with hemoglobin levels at delivery. Birth weight was negatively associated with peripheral IL-4 levels at delivery. Our multi-biomarker multicenter study is the first comprehensive one to characterize the immunological signature of P. vivax infection in pregnancy thus far. In conclusion, data show that while TH1 and pro-inflammatory responses are dominant during P. vivax infection in pregnancy, antiinflammatory cytokines may compensate excessive inflammation avoiding poor delivery outcomes, and skewness toward a TH2 response may trigger worse delivery outcomes. CCL11, a chemokine largely neglected in the field of malaria, emerges as an important marker of exposure or ... |
format |
Article in Journal/Newspaper |
author |
Carlota Dobaño Azucena Bardají Myriam Arévalo-Herrera Flor E Martínez-Espinosa Camila Bôtto-Menezes Norma Padilla Michela Menegon Swati Kochar Sanjay Kumar Kochar Holger Unger Maria Ome-Kaius Anna Rosanas-Urgell Adriana Malheiros Maria Eugenia Castellanos Dhiraj Hans Meghna Desai Aina Casellas Chetan E Chitnis Carlo Severini Ivo Mueller Stephen Rogerson Clara Menéndez Pilar Requena |
author_facet |
Carlota Dobaño Azucena Bardají Myriam Arévalo-Herrera Flor E Martínez-Espinosa Camila Bôtto-Menezes Norma Padilla Michela Menegon Swati Kochar Sanjay Kumar Kochar Holger Unger Maria Ome-Kaius Anna Rosanas-Urgell Adriana Malheiros Maria Eugenia Castellanos Dhiraj Hans Meghna Desai Aina Casellas Chetan E Chitnis Carlo Severini Ivo Mueller Stephen Rogerson Clara Menéndez Pilar Requena |
author_sort |
Carlota Dobaño |
title |
Cytokine signatures of Plasmodium vivax infection during pregnancy and delivery outcomes. |
title_short |
Cytokine signatures of Plasmodium vivax infection during pregnancy and delivery outcomes. |
title_full |
Cytokine signatures of Plasmodium vivax infection during pregnancy and delivery outcomes. |
title_fullStr |
Cytokine signatures of Plasmodium vivax infection during pregnancy and delivery outcomes. |
title_full_unstemmed |
Cytokine signatures of Plasmodium vivax infection during pregnancy and delivery outcomes. |
title_sort |
cytokine signatures of plasmodium vivax infection during pregnancy and delivery outcomes. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2020 |
url |
https://doi.org/10.1371/journal.pntd.0008155 https://doaj.org/article/284c26da8cb944a28b3db6b84dfaef30 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 14, Iss 5, p e0008155 (2020) |
op_relation |
https://doi.org/10.1371/journal.pntd.0008155 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0008155 https://doaj.org/article/284c26da8cb944a28b3db6b84dfaef30 |
op_doi |
https://doi.org/10.1371/journal.pntd.0008155 |
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PLOS Neglected Tropical Diseases |
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14 |
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5 |
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e0008155 |
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