Containing Ebola at the Source with Ring Vaccination.
Interim results from the Guinea Ebola ring vaccination trial suggest high efficacy of the rVSV-ZEBOV vaccine. These findings open the door to the use of ring vaccination strategies in which the contacts and contacts of contacts of each index case are promptly vaccinated to contain future Ebola virus...
Published in: | PLOS Neglected Tropical Diseases |
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Online Access: | https://doi.org/10.1371/journal.pntd.0005093 https://doaj.org/article/283a9318e75846b486d87d84bb61f05f |
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ftdoajarticles:oai:doaj.org/article:283a9318e75846b486d87d84bb61f05f 2023-05-15T15:07:17+02:00 Containing Ebola at the Source with Ring Vaccination. Stefano Merler Marco Ajelli Laura Fumanelli Stefano Parlamento Ana Pastore Y Piontti Natalie E Dean Giovanni Putoto Dante Carraro Ira M Longini M Elizabeth Halloran Alessandro Vespignani 2016-11-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0005093 https://doaj.org/article/283a9318e75846b486d87d84bb61f05f EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC5091901?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0005093 https://doaj.org/article/283a9318e75846b486d87d84bb61f05f PLoS Neglected Tropical Diseases, Vol 10, Iss 11, p e0005093 (2016) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2016 ftdoajarticles https://doi.org/10.1371/journal.pntd.0005093 2022-12-31T15:44:48Z Interim results from the Guinea Ebola ring vaccination trial suggest high efficacy of the rVSV-ZEBOV vaccine. These findings open the door to the use of ring vaccination strategies in which the contacts and contacts of contacts of each index case are promptly vaccinated to contain future Ebola virus disease outbreaks. To provide a numerical estimate of the effectiveness of ring vaccination strategies we introduce a spatially explicit agent-based model to simulate Ebola outbreaks in the Pujehun district, Sierra Leone, structurally similar to previous modelling approaches. We find that ring vaccination can successfully contain an outbreak for values of the effective reproduction number up to 1.6. Through an extensive sensitivity analysis of parameters characterising the readiness and capacity of the health care system, we identify interventions that, alongside ring vaccination, could increase the likelihood of containment. In particular, shortening the time from symptoms onset to hospitalisation to 2-3 days on average through improved contact tracing procedures, adding a 2km spatial component to the vaccination ring, and decreasing human mobility by quarantining affected areas might contribute increase our ability to contain outbreaks with effective reproduction number up to 2.6. These results have implications for future control of Ebola and other emerging infectious disease threats. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 10 11 e0005093 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Stefano Merler Marco Ajelli Laura Fumanelli Stefano Parlamento Ana Pastore Y Piontti Natalie E Dean Giovanni Putoto Dante Carraro Ira M Longini M Elizabeth Halloran Alessandro Vespignani Containing Ebola at the Source with Ring Vaccination. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Interim results from the Guinea Ebola ring vaccination trial suggest high efficacy of the rVSV-ZEBOV vaccine. These findings open the door to the use of ring vaccination strategies in which the contacts and contacts of contacts of each index case are promptly vaccinated to contain future Ebola virus disease outbreaks. To provide a numerical estimate of the effectiveness of ring vaccination strategies we introduce a spatially explicit agent-based model to simulate Ebola outbreaks in the Pujehun district, Sierra Leone, structurally similar to previous modelling approaches. We find that ring vaccination can successfully contain an outbreak for values of the effective reproduction number up to 1.6. Through an extensive sensitivity analysis of parameters characterising the readiness and capacity of the health care system, we identify interventions that, alongside ring vaccination, could increase the likelihood of containment. In particular, shortening the time from symptoms onset to hospitalisation to 2-3 days on average through improved contact tracing procedures, adding a 2km spatial component to the vaccination ring, and decreasing human mobility by quarantining affected areas might contribute increase our ability to contain outbreaks with effective reproduction number up to 2.6. These results have implications for future control of Ebola and other emerging infectious disease threats. |
format |
Article in Journal/Newspaper |
author |
Stefano Merler Marco Ajelli Laura Fumanelli Stefano Parlamento Ana Pastore Y Piontti Natalie E Dean Giovanni Putoto Dante Carraro Ira M Longini M Elizabeth Halloran Alessandro Vespignani |
author_facet |
Stefano Merler Marco Ajelli Laura Fumanelli Stefano Parlamento Ana Pastore Y Piontti Natalie E Dean Giovanni Putoto Dante Carraro Ira M Longini M Elizabeth Halloran Alessandro Vespignani |
author_sort |
Stefano Merler |
title |
Containing Ebola at the Source with Ring Vaccination. |
title_short |
Containing Ebola at the Source with Ring Vaccination. |
title_full |
Containing Ebola at the Source with Ring Vaccination. |
title_fullStr |
Containing Ebola at the Source with Ring Vaccination. |
title_full_unstemmed |
Containing Ebola at the Source with Ring Vaccination. |
title_sort |
containing ebola at the source with ring vaccination. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2016 |
url |
https://doi.org/10.1371/journal.pntd.0005093 https://doaj.org/article/283a9318e75846b486d87d84bb61f05f |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 10, Iss 11, p e0005093 (2016) |
op_relation |
http://europepmc.org/articles/PMC5091901?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0005093 https://doaj.org/article/283a9318e75846b486d87d84bb61f05f |
op_doi |
https://doi.org/10.1371/journal.pntd.0005093 |
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PLOS Neglected Tropical Diseases |
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10 |
container_issue |
11 |
container_start_page |
e0005093 |
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1766338823225081856 |