Neuropathic pain and psychological morbidity in patients with treated leprosy: a cross-sectional prevalence study in Mumbai.
BACKGROUND: Neuropathic pain has been little studied in leprosy. We assessed the prevalence and clinical characteristics of neuropathic pain and the validity of the Douleur Neuropathique 4 questionnaire as a screening tool for neuropathic pain in patients with treated leprosy. The association of neu...
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ftdoajarticles:oai:doaj.org/article:281af744d4de4d92ba9bdab7fc5b64b9 2023-05-15T15:08:31+02:00 Neuropathic pain and psychological morbidity in patients with treated leprosy: a cross-sectional prevalence study in Mumbai. Estrella Lasry-Levy Aki Hietaharju Vivek Pai Ramaswamy Ganapati Andrew S C Rice Maija Haanpää Diana N J Lockwood 2011-01-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0000981 https://doaj.org/article/281af744d4de4d92ba9bdab7fc5b64b9 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC3050898?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0000981 https://doaj.org/article/281af744d4de4d92ba9bdab7fc5b64b9 PLoS Neglected Tropical Diseases, Vol 5, Iss 3, p e981 (2011) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2011 ftdoajarticles https://doi.org/10.1371/journal.pntd.0000981 2022-12-31T05:59:59Z BACKGROUND: Neuropathic pain has been little studied in leprosy. We assessed the prevalence and clinical characteristics of neuropathic pain and the validity of the Douleur Neuropathique 4 questionnaire as a screening tool for neuropathic pain in patients with treated leprosy. The association of neuropathic pain with psychological morbidity was also evaluated. METHODOLOGY/PRINCIPAL FINDINGS: Adult patients who had completed multi-drug therapy for leprosy were recruited from several Bombay Leprosy Project clinics. Clinical neurological examination, assessment of leprosy affected skin and nerves and pain evaluation were performed for all patients. Patients completed the Douleur Neuropathique 4 and the 12-item General Health Questionnaire to identify neuropathic pain and psychological morbidity. CONCLUSIONS/SIGNIFICANCE: One hundred and one patients were recruited, and 22 (21.8%) had neuropathic pain. The main sensory symptoms were numbness (86.4%), tingling (68.2%), hypoesthesia to touch (81.2%) and pinprick (72.7%). Neuropathic pain was associated with nerve enlargement and tenderness, painful skin lesions and with psychological morbidity. The Douleur Neuropathique 4 had a sensitivity of 100% and specificity of 92% in diagnosing neuropathic pain. The Douleur Neuropathique 4 is a simple tool for the screening of neuropathic pain in leprosy patients. Psychological morbidity was detected in 15% of the patients and 41% of the patients with neuropathic pain had psychological morbidity. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Bombay ENVELOPE(-60.783,-60.783,-63.900,-63.900) PLoS Neglected Tropical Diseases 5 3 e981 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Estrella Lasry-Levy Aki Hietaharju Vivek Pai Ramaswamy Ganapati Andrew S C Rice Maija Haanpää Diana N J Lockwood Neuropathic pain and psychological morbidity in patients with treated leprosy: a cross-sectional prevalence study in Mumbai. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
BACKGROUND: Neuropathic pain has been little studied in leprosy. We assessed the prevalence and clinical characteristics of neuropathic pain and the validity of the Douleur Neuropathique 4 questionnaire as a screening tool for neuropathic pain in patients with treated leprosy. The association of neuropathic pain with psychological morbidity was also evaluated. METHODOLOGY/PRINCIPAL FINDINGS: Adult patients who had completed multi-drug therapy for leprosy were recruited from several Bombay Leprosy Project clinics. Clinical neurological examination, assessment of leprosy affected skin and nerves and pain evaluation were performed for all patients. Patients completed the Douleur Neuropathique 4 and the 12-item General Health Questionnaire to identify neuropathic pain and psychological morbidity. CONCLUSIONS/SIGNIFICANCE: One hundred and one patients were recruited, and 22 (21.8%) had neuropathic pain. The main sensory symptoms were numbness (86.4%), tingling (68.2%), hypoesthesia to touch (81.2%) and pinprick (72.7%). Neuropathic pain was associated with nerve enlargement and tenderness, painful skin lesions and with psychological morbidity. The Douleur Neuropathique 4 had a sensitivity of 100% and specificity of 92% in diagnosing neuropathic pain. The Douleur Neuropathique 4 is a simple tool for the screening of neuropathic pain in leprosy patients. Psychological morbidity was detected in 15% of the patients and 41% of the patients with neuropathic pain had psychological morbidity. |
format |
Article in Journal/Newspaper |
author |
Estrella Lasry-Levy Aki Hietaharju Vivek Pai Ramaswamy Ganapati Andrew S C Rice Maija Haanpää Diana N J Lockwood |
author_facet |
Estrella Lasry-Levy Aki Hietaharju Vivek Pai Ramaswamy Ganapati Andrew S C Rice Maija Haanpää Diana N J Lockwood |
author_sort |
Estrella Lasry-Levy |
title |
Neuropathic pain and psychological morbidity in patients with treated leprosy: a cross-sectional prevalence study in Mumbai. |
title_short |
Neuropathic pain and psychological morbidity in patients with treated leprosy: a cross-sectional prevalence study in Mumbai. |
title_full |
Neuropathic pain and psychological morbidity in patients with treated leprosy: a cross-sectional prevalence study in Mumbai. |
title_fullStr |
Neuropathic pain and psychological morbidity in patients with treated leprosy: a cross-sectional prevalence study in Mumbai. |
title_full_unstemmed |
Neuropathic pain and psychological morbidity in patients with treated leprosy: a cross-sectional prevalence study in Mumbai. |
title_sort |
neuropathic pain and psychological morbidity in patients with treated leprosy: a cross-sectional prevalence study in mumbai. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2011 |
url |
https://doi.org/10.1371/journal.pntd.0000981 https://doaj.org/article/281af744d4de4d92ba9bdab7fc5b64b9 |
long_lat |
ENVELOPE(-60.783,-60.783,-63.900,-63.900) |
geographic |
Arctic Bombay |
geographic_facet |
Arctic Bombay |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 5, Iss 3, p e981 (2011) |
op_relation |
http://europepmc.org/articles/PMC3050898?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0000981 https://doaj.org/article/281af744d4de4d92ba9bdab7fc5b64b9 |
op_doi |
https://doi.org/10.1371/journal.pntd.0000981 |
container_title |
PLoS Neglected Tropical Diseases |
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5 |
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3 |
container_start_page |
e981 |
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1766339873830076416 |